Activation of glutathione peroxidase 4 as a novel anti-inflammatory strategy C Li, X Deng, X Xie, Y Liu, JP Friedmann Angeli, L Lai Frontiers in pharmacology 9, 385435, 2018 | 127 | 2018 |
Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity Q Wang, MV Liberti, P Liu, X Deng, Y Liu, JW Locasale, L Lai Cell chemical biology 24 (1), 55-65, 2017 | 125 | 2017 |
The STING phase-separator suppresses innate immune signalling X Yu, L Zhang, J Shen, Y Zhai, Q Jiang, M Yi, X Deng, Z Ruan, R Fang, ... Nature Cell Biology 23 (4), 330-340, 2021 | 111 | 2021 |
Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 C Li, X Deng, W Zhang, X Xie, M Conrad, Y Liu, JPF Angeli, L Lai Journal of Medicinal Chemistry 62 (1), 266-275, 2018 | 101 | 2018 |
Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds P Liu, H Liu, Q Sun, H Liang, C Li, X Deng, Y Liu, L Lai European journal of medicinal chemistry 206, 112702, 2020 | 56 | 2020 |
Regulation of interferon production as a potential strategy for COVID-19 treatment X Deng, X Yu, J Pei arXiv preprint arXiv:2003.00751, 2020 | 40 | 2020 |
Discovery of a novel series of thienopyrimidine as highly potent and selective PI3K inhibitors F Han, S Lin, P Liu, X Liu, J Tao, X Deng, C Yi, H Xu ACS Medicinal Chemistry Letters 6 (4), 434-438, 2015 | 39 | 2015 |
Benzo [d] isothiazole 1, 1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 E Shang, Y Wu, P Liu, Y Liu, W Zhu, X Deng, C He, S He, C Li, L Lai Bioorganic & Medicinal Chemistry Letters 24 (12), 2764-2767, 2014 | 39 | 2014 |
Discovery of highly potent TNFα inhibitors using virtual screen Q Shen, J Chen, Q Wang, X Deng, Y Liu, L Lai European Journal of Medicinal Chemistry 85, 119-126, 2014 | 20 | 2014 |
CavitySpace: a database of potential ligand binding sites in the human proteome S Wang, H Lin, Z Huang, Y He, X Deng, Y Xu, J Pei, L Lai Biomolecules 12 (7), 967, 2022 | 17 | 2022 |
A novel allosteric inhibitor that prevents IKKβ activation H Liu, H Liang, H Meng, X Deng, X Zhang, L Lai Medchemcomm 9 (2), 239-243, 2018 | 15 | 2018 |
A convenient synthesis of thiazolidin-2-ones from thiazolidine-2-thiones: Antibiotic activity and revisiting the mechanism X Deng, N Chen, Z Wang, X Li, H Hu, J Xu Phosphorus, Sulfur, and Silicon and the Related Elements 186 (7), 1563-1571, 2011 | 13 | 2011 |
Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors X Deng, X Zhang, B Tang, H Liu, Q Shen, Y Liu, L Lai Frontiers in Chemistry 6, 98, 2018 | 11 | 2018 |
Practical Corey-Chaykovsky Epoxidation: Scope and Limitation H Yu, X Deng, S Cao, J Xu Letters in Organic Chemistry 8 (7), 509-514, 2011 | 9 | 2011 |
Design, synthesis, and biological evaluation of novel multifunctional rolipram–tranilast hybrids as potential treatment for traumatic brain injury J Lu, C Chen, X Deng, MSH Mak, Z Zhu, X He, J Liang, SK Maddili, ... ACS Chemical Neuroscience 11 (15), 2348-2360, 2020 | 4 | 2020 |
Proxalutamide (GT0918), a novel androgen receptor (AR) antagonist, targeting resistance mechanisms to AR signaling-directed castration-resistant prostate cancer (CRPC) therapies L Ma, Q Zhou, Y He, J Chen, K Zhou, Q Zhou, C Chen, JS Xiang, X Deng, ... Cancer Research 79 (13_Supplement), 3861-3861, 2019 | 3 | 2019 |
Deep Learning Model of Dock by Dock Process Significantly Accelerate the Process of Docking-based Virtual Screening W Ma, Q Xie, J Zhang, S Li, Y Xu, X Deng, W Zhang arXiv preprint arXiv:2110.10918, 2021 | 2 | 2021 |
Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (−)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice Y Zhu, L Wang, J Li, Y Zhao, X Yu, P Liu, X Deng, J Liu, F Yang, Y Zhang, ... Cell Chemical Biology, 2024 | 1 | 2024 |
Exploration on learning molecular docking with deep learning models Q Xie, W Ma, J Zhang, S Li, X Deng, Y Xu, W Zhang Quantitative Biology 11 (3), 320-331, 2023 | | 2023 |
Correction to “Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram–Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury” J Lu, C Chen, X Deng, MSH Mak, Z Zhu, X He, J Liang, SK Maddili, ... ACS Chemical Neuroscience 14 (14), 2582-2582, 2023 | | 2023 |