フォロー
Johnathan Guest
Johnathan Guest
Postdoc, AstraZeneca
確認したメール アドレス: astrazeneca.com
タイトル
引用先
引用先
Blind prediction of homo‐and hetero‐protein complexes: The CASP13‐CAPRI experiment
MF Lensink, G Brysbaert, N Nadzirin, S Velankar, RAG Chaleil, T Gerguri, ...
Proteins: Structure, Function, and Bioinformatics 87 (12), 1200-1221, 2019
1172019
Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment
MF Lensink, G Brysbaert, T Mauri, N Nadzirin, S Velankar, RAG Chaleil, ...
Proteins: Structure, Function, and Bioinformatics 89 (12), 1800-1823, 2021
812021
An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants
JD Guest, T Vreven, J Zhou, I Moal, JR Jeliazkov, JJ Gray, Z Weng, ...
Structure 29 (6), 606-621. e5, 2021
762021
Zika virus NS5 protein antagonizes type I interferon production via blocking TBK1 activation
S Lin, S Yang, J He, JD Guest, Z Ma, L Yang, BG Pierce, Q Tang, ...
Virology 527, 180-187, 2019
712019
Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis
R Gopal, K Jackson, N Tzarum, L Kong, A Ettenger, J Guest, JM Pfaff, ...
PLoS pathogens 13 (12), e1006735, 2017
702017
CoV3D: a database of high resolution coronavirus protein structures
R Gowthaman, JD Guest, R Yin, J Adolf-Bryfogle, WR Schief, BG Pierce
Nucleic acids research 49 (D1), D282-D287, 2021
672021
Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design
ZY Keck, BG Pierce, P Lau, J Lu, Y Wang, A Underwood, RA Bull, ...
PLoS pathogens 15 (5), e1007772, 2019
582019
Antigenicity and immunogenicity of differentially glycosylated hepatitis C virus E2 envelope proteins expressed in mammalian and insect cells
RA Urbanowicz, R Wang, JE Schiel, Z Keck, MC Kerzic, P Lau, ...
Journal of virology 93 (7), 10.1128/jvi. 01403-18, 2019
562019
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors
D Wu, A Kolesnikov, R Yin, JD Guest, R Gowthaman, A Shmelev, ...
Nature Communications 13 (1), 19, 2022
272022
An antigenically diverse, representative panel of envelope glycoproteins for hepatitis C virus vaccine development
JH Salas, RA Urbanowicz, JD Guest, N Frumento, A Figueroa, KE Clark, ...
Gastroenterology 162 (2), 562-574, 2022
232022
Structure-based design of hepatitis C virus E2 glycoprotein improves serum binding and cross-neutralization
BG Pierce, ZY Keck, R Wang, P Lau, K Garagusi, K Elkholy, EA Toth, ...
Journal of virology 94 (22), 10.1128/jvi. 00704-20, 2020
232020
Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer
JD Guest, R Wang, KH Elkholy, A Chagas, KL Chao, TE Cleveland IV, ...
Proceedings of the National Academy of Sciences 118 (3), e2015149118, 2021
222021
Computational modeling of hepatitis C virus envelope glycoprotein structure and recognition
JD Guest, BG Pierce
Frontiers in Immunology 9, 367934, 2018
182018
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants
R Yin, JD Guest, G Taherzadeh, R Gowthaman, I Mittra, J Quackenbush, ...
PLoS Computational Biology 17 (9), e1009380, 2021
17*2021
Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials
B Ahani, KM Tuffy, AA Aksyuk, D Wilkins, ME Abram, R Dagan, ...
Nature Communications 14 (1), 4347, 2023
162023
Impact of AlphaFold on structure prediction of protein complexes: the CASP15‐CAPRI experiment
MF Lensink, G Brysbaert, N Raouraoua, PA Bates, M Giulini, RV Honorato, ...
Proteins: Structure, Function, and Bioinformatics 91 (12), 1658-1683, 2023
152023
Structure-based and rational design of a hepatitis C virus vaccine
JD Guest, BG Pierce
Viruses 13 (5), 837, 2021
92021
Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate
R Wang, S Suzuki, JD Guest, B Heller, M Almeda, AK Andrianov, A Marin, ...
Proceedings of the National Academy of Sciences 119 (11), e2112008119, 2022
82022
Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
MC Metcalf, BM Janus, R Yin, R Wang, JD Guest, E Pozharski, M Law, ...
Nature Communications 14 (1), 3980, 2023
52023
Molecular characterization of AZD7442 (tixagevimab-cilgavimab) neutralization of SARS-CoV-2 Omicron subvariants
TL Roe, T Brady, N Schuko, A Nguyen, J Beloor, JD Guest, AA Aksyuk, ...
Microbiology Spectrum 11 (2), e00333-23, 2023
52023
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