| The mechanisms of action of metformin G Rena, DG Hardie, ER Pearson Diabetologia 60 (9), 1577-1585, 2017 | 2060 | 2017 |
| Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B G Rena, S Guo, SC Cichy, TG Unterman, P Cohen Journal of Biological Chemistry 274 (24), 17179-17183, 1999 | 944 | 1999 |
| Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter … S Guo, G Rena, S Cichy, X He, P Cohen, T Unterman Journal of Biological Chemistry 274 (24), 17184-17192, 1999 | 690 | 1999 |
| Anti-inflammatory effects of metformin irrespective of diabetes status AR Cameron, VL Morrison, D Levin, M Mohan, C Forteath, C Beall, ... Circulation research 119 (5), 652-665, 2016 | 656 | 2016 |
| Molecular mechanism of action of metformin: old or new insights? G Rena, ER Pearson, K Sakamoto Diabetologia 56, 1898-1906, 2013 | 633 | 2013 |
| Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting G Rena, AR Prescott, S Guo, P Cohen, TG Unterman Biochemical Journal 354 (3), 605-612, 2001 | 332 | 2001 |
| The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site YL Woods, G Rena, N Morrice, A Barthel, W Becker, S Guo, TG Unterman, ... Biochemical Journal 355 (3), 597-607, 2001 | 323 | 2001 |
| D4476, a cell‐permeant inhibitor of CK1, suppresses the site‐specific phosphorylation and nuclear exclusion of FOXO1a G Rena, J Bain, M Elliott, P Cohen EMBO reports 5 (1), 60-65, 2004 | 305 | 2004 |
| Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion G Rena, YL Woods, AR Prescott, M Peggie, TG Unterman, MR Williams, ... The EMBO journal 21 (9), 2263-2271, 2002 | 301 | 2002 |
| Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure … C Maack, M Lehrke, J Backs, FR Heinzel, JS Hulot, N Marx, WJ Paulus, ... European heart journal 39 (48), 4243-4254, 2018 | 241 | 2018 |
| Metformin selectively targets redox control of complex I energy transduction AR Cameron, L Logie, K Patel, S Erhardt, S Bacon, P Middleton, J Harthill, ... Redox Biology 14, 187-197, 2018 | 144 | 2018 |
| Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3): two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with … Y Shakur, K Takeda, Y Kenan, ZX Yu, G Rena, D Brandt, MD Houslay, ... Journal of Biological Chemistry 275 (49), 38749-38761, 2000 | 138 | 2000 |
| Cellular responses to the metal-binding properties of metformin L Logie, J Harthill, K Patel, S Bacon, DL Hamilton, K Macrae, ... Diabetes 61 (6), 1423-1433, 2012 | 126 | 2012 |
| Repurposing metformin for cardiovascular disease G Rena, CC Lang Circulation 137 (5), 422-424, 2018 | 123 | 2018 |
| Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart MM Kostic, S Erdogan, G Rena, G Borchert, B Hoch, S Bartel, G Scotland, ... Journal of molecular and cellular cardiology 29 (11), 3135-3146, 1997 | 104 | 1997 |
| Black tea polyphenols mimic insulin/insulin‐like growth factor‐1 signalling to the longevity factor FOXO1a AR Cameron, S Anton, L Melville, NP Houston, S Dayal, GJ McDougall, ... Aging cell 7 (1), 69-77, 2008 | 87 | 2008 |
| Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10 G Rena, F Begg, A Ross, C MacKenzie, I McPhee, L Campbell, E Huston, ... Molecular Pharmacology 59 (5), 996-1011, 2001 | 84 | 2001 |
| Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin S Anton, L Melville, G Rena Cellular signalling 19 (2), 378-383, 2007 | 76 | 2007 |
| Biomolecular mode of action of metformin in relation to its copper binding properties P Repiscak, S Erhardt, G Rena, MJ Paterson Biochemistry 53 (4), 787-795, 2014 | 62 | 2014 |
| Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX YL Woods, G Rena Biochemical Society Transactions 30 (4), 391-397, 2002 | 61 | 2002 |
