Shigetomo Fukuhara
Shigetomo Fukuhara
日本医科大学 先端医学研究所 病態解析学部門
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Cbl-b regulates the CD28 dependence of T-cell activation
YJ Chiang, HK Kole, K Brown, M Naramura, S Fukuhara, RJ Hu, IK Jang, ...
Nature 403 (6766), 216-220, 2000
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
S Fukuhara, A Sakurai, H Sano, A Yamagishi, S Somekawa, N Takakura, ...
Molecular and cellular biology 25 (1), 136-146, 2005
A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
S Fukuhara, C Murga, M Zohar, T Igishi, JS Gutkind
Journal of Biological Chemistry 274 (9), 5868-5879, 1999
Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1
S Fukuhara, K Sako, T Minami, K Noda, HZ Kim, T Kodama, M Shibuya, ...
Nature cell biology 10 (5), 513-526, 2008
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance
M Tabata, T Kadomatsu, S Fukuhara, K Miyata, Y Ito, M Endo, T Urano, ...
Cell metabolism 10 (3), 178-188, 2009
Identification of multiple novel epididymis-specific β-defensin isoforms in humans and mice
Y Yamaguchi, T Nagase, R Makita, S Fukuhara, T Tomita, T Tominaga, ...
The Journal of Immunology 169 (5), 2516-2523, 2002
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice
S Fukuhara, S Simmons, S Kawamura, A Inoue, Y Orba, T Tokudome, ...
The Journal of clinical investigation 122 (4), 1416-1426, 2012
Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho
S Fukuhara, H Chikumi, JS Gutkind
FEBS letters 485 (2-3), 183-188, 2000
RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?
S Fukuhara, H Chikumi, JS Gutkind
Oncogene 20 (13), 1661-1668, 2001
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome
N Makita, E Behr, W Shimizu, M Horie, A Sunami, L Crotti, E Schulze-Bahr, ...
The Journal of clinical investigation 118 (6), 2219-2229, 2008
Flow-dependent endothelial YAP regulation contributes to vessel maintenance
H Nakajima, K Yamamoto, S Agarwala, K Terai, H Fukui, S Fukuhara, ...
Developmental cell 40 (6), 523-536. e6, 2017
A novel role for phosphatidylinositol 3-kinase β in signaling from G protein-coupled receptors to Akt
C Murga, S Fukuhara, JS Gutkind
Journal of Biological Chemistry 275 (16), 12069-12073, 2000
Tip cell-specific requirement for an atypical Gpr124-and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis
B Vanhollebeke, OA Stone, N Bostaille, C Cho, Y Zhou, E Maquet, ...
elife 4, e06489, 2015
Angiopoietin-1Tie2 receptor signaling in vascular quiescence and angiogenesis
S Fukuhara, K Sako, K Noda, J Zhang, M Minami, N Mochizuki
Histology and histopathology, 2010
Conformational switch of angiotensin II type 1 receptor underlying mechanical stress‐induced activation
N Yasuda, S Miura, H Akazawa, T Tanaka, Y Qin, Y Kiya, S Imaizumi, ...
EMBO reports 9 (2), 179-186, 2008
Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase
H Chikumi, S Fukuhara, JS Gutkind
Journal of Biological Chemistry 277 (14), 12463-12473, 2002
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish
K Ando, S Fukuhara, N Izumi, H Nakajima, H Fukui, RN Kelsh, ...
Development 143 (8), 1328-1339, 2016
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion
A Sakurai, S Fukuhara, A Yamagishi, K Sako, Y Kamioka, M Masuda, ...
Molecular biology of the cell 17 (2), 966-976, 2006
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock
CM Mikelis, M Simaan, K Ando, S Fukuhara, A Sakurai, ...
Nature communications 6 (1), 6725, 2015
Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish
Y Wakayama, S Fukuhara, K Ando, M Matsuda, N Mochizuki
Developmental cell 32 (1), 109-122, 2015
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