Tomohiro Mizutani
Tomohiro Mizutani
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Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
S Yui, T Nakamura, T Sato, Y Nemoto, T Mizutani, X Zheng, S Ichinose, ...
Nature medicine 18 (4), 618-623, 2012
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
J Drost, R Van Boxtel, F Blokzijl, T Mizutani, N Sasaki, V Sasselli, J de Ligt, ...
Science 358 (6360), 234-238, 2017
Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon
M Fukuda, T Mizutani, W Mochizuki, T Matsumoto, K Nozaki, Y Sakamaki, ...
Genes & development 28 (16), 1752-1757, 2014
Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes
K Nozaki, W Mochizuki, Y Matsumoto, T Matsumoto, M Fukuda, T Mizutani, ...
Journal of gastroenterology 51 (3), 206-213, 2016
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli
C Pleguezuelos-Manzano, J Puschhof, AR Huber, A van Hoeck, ...
Nature 580 (7802), 269-273, 2020
Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells
T Murano, R Okamoto, G Ito, T Nakata, S Hibiya, H Shimizu, S Fujii, ...
Biochemical and biophysical research communications 443 (3), 840-846, 2014
Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro
T Mizutani, T Nakamura, R Morikawa, M Fukuda, W Mochizuki, ...
Biochemical and biophysical research communications 419 (2), 238-243, 2012
Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
H Shimizu, R Okamoto, G Ito, S Fujii, T Nakata, K Suzuki, T Murano, ...
PeerJ 2, e370, 2014
Contribution of ATOH1+ cells to the homeostasis, repair, and tumorigenesis of the colonic epithelium
F Ishibashi, H Shimizu, T Nakata, S Fujii, K Suzuki, A Kawamoto, S Anzai, ...
Stem cell reports 10 (1), 27-42, 2018
PGE 2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells
S Fujii, K Suzuki, A Kawamoto, F Ishibashi, T Nakata, T Murano, G Ito, ...
Scientific reports 6 (1), 1-15, 2016
Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells
G Ito, R Okamoto, T Murano, H Shimizu, S Fujii, T Nakata, T Mizutani, ...
PloS one 8 (11), e79693, 2013
Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors
T Nakata, H Shimizu, S Nagata, G Ito, S Fujii, K Suzuki, A Kawamoto, ...
Biochemical and biophysical research communications 482 (4), 1296-1303, 2017
Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt
N Horita, K Tsuchiya, R Hayashi, K Fukushima, S Hibiya, M Fukuda, ...
Biochemical and biophysical research communications 454 (4), 493-499, 2014
Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism
T Matsumoto, W Mochizuki, Y Nibe, S Akiyama, Y Matsumoto, K Nozaki, ...
PloS one 11 (8), e0162049, 2016
MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance
SPJ Joosten, T Mizutani, M Spaargaren, H Clevers, ST Pals
Gastroenterology 157 (4), 1153-1155. e1, 2019
Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
T Mizutani, Y Tsukamoto, H Clevers
The Journal of cell biology 216 (6), 1505, 2017
Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies
N Tanaka, S Kanatani, D Kaczynska, K Fukumoto, L Louhivuori, ...
Nature Biomedical Engineering 4 (9), 875-888, 2020
Primary Intestinal Epithelial Organoid Culture
T Mizutani, H Clevers
Intestinal Stem Cells, 185-200, 2020
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