|β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE|
R Vassar, BD Bennett, S Babu-Khan, S Kahn, EA Mendiaz, P Denis, ...
Science 286 (5440), 735, 1999
|Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial …|
D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ...
Nature medicine 2 (8), 864-870, 1996
|Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production|
M Citron, T Oltersdorf, C Haass, L McConlogue, AY Hung, P Seubert, ...
Nature 360 (6405), 672-674, 1992
|Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice|
M Citron, D Westaway, W Xia, G Carlson, T Diehl, G Levesque, ...
Nature medicine 3 (1), 67-72, 1997
|Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation|
Y Luo, B Bolon, S Kahn, BD Bennett, S Babu-Khan, P Denis, W Fan, ...
Nature neuroscience 4 (3), 2001-03, 2001
|Alzheimer's disease: strategies for disease modification|
Nature reviews Drug discovery 9 (5), 387-398, 2010
|Control of peripheral nerve myelination by the ß-secretase BACE1|
M Willem, AN Garratt, B Novak, M Citron, S Kaufmann, A Rittger, ...
Science 314 (5799), 664, 2006
|Both familial Parkinson’s disease mutations accelerate α-synuclein aggregation|
L Narhi, SJ Wood, S Steavenson, Y Jiang, GM Wu, D Anafi, SA Kaufman, ...
Journal of Biological Chemistry 274 (14), 9843, 1999
|α-Synuclein fibrillogenesis is nucleation-dependent|
SJ Wood, J Wypych, S Steavenson, JC Louis, M Citron, AL Biere
Journal of Biological Chemistry 274 (28), 19509, 1999
|Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease|
LB Yang, K Lindholm, R Yan, M Citron, W Xia, XL Yang, T Beach, L Sue, ...
Nature medicine 9 (1), 3-4, 2003
|The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway|
C Haass, CA Lemere, A Capell, M Citron, P Seubert, D Schenk, L Lannfelt, ...
Nature medicine 1 (12), 1291-1296, 1995
|Strategies for disease modification in Alzheimer's disease|
Nature Reviews Neuroscience 5 (9), 677-685, 2004
|BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease|
M Ohno, EA Sametsky, LH Younkin, H Oakley, SG Younkin, M Citron, ...
Neuron 41 (1), 27-33, 2004
|Anti-inflammatory drug therapy alters β-amyloid processing and deposition in an animal model of Alzheimer's disease|
Q Yan, J Zhang, H Liu, S Babu-Khan, R Vassar, AL Biere, M Citron, ...
Journal of Neuroscience 23 (20), 7504-7509, 2003
|Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients|
R Li, K Lindholm, LB Yang, X Yue, M Citron, R Yan, T Beach, L Sue, ...
Proceedings of the National Academy of Sciences of the United States of …, 2004
|Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.|
AY Hung, C Haass, RM Nitsch, WQ Qiu, M Citron, RJ Wurtman, ...
Journal of Biological Chemistry 268 (31), 22959-22962, 1993
|Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation|
M Citron, C Vigo-Pelfrey, DB Teplow, C Miller, D Schenk, J Johnston, ...
Proceedings of the National Academy of Sciences 91 (25), 11993, 1994
|The proteolytic fragments of the Alzheimer’s disease-associated presenilin-1 form heterodimers and occur as a 100–150-kDa molecular mass complex|
A Capell, J Grünberg, B Pesold, A Diehlmann, M Citron, R Nixon, ...
Journal of Biological Chemistry 273 (6), 3205, 1998
|Expression analysis of BACE2 in brain and peripheral tissues|
BD Bennett, S Babu-Khan, R Loeloff, JC Louis, E Curran, M Citron, ...
Journal of Biological Chemistry 275 (27), 20647-20651, 2000
|Presenilin proteins undergo heterogeneous endoproteolysis between Thr291and Ala299and occur as stable N-and C-terminal fragments in normal and Alzheimer brain tissue|
MB Podlisny, M Citron, P Amarante, R Sherrington, W Xia, J Zhang, ...
Neurobiology of disease 3 (4), 325-337, 1997