Alejandro Chavez

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George ChurchHarvard Medical SchoolVerified email at harvard.edu
James J CollinsMIT; Wyss Institute, Harvard; Broad Institute of MIT & HarvardVerified email at mit.edu
Benjamin W Pruitt10x GenomicsVerified email at 10xgenomics.com
Xiaoge GuoNabla Bio / Wyss Institute at Harvard / Harvard Medical SchoolVerified email at wyss.harvard.edu
Samira KianiSchool of Biological and Health Systems Engineering-Arizona State UniversityVerified email at asu.edu
Rebecca S ShapiroAssociate Professor, University of GuelphVerified email at uoguelph.ca
F. Brad Johnson, MD, PhDProfessor of Pathology and Laboratory MedicineVerified email at pennmedicine.upenn.edu
David Hoprofessor of medicine, Columbia universityVerified email at cumc.columbia.edu
Sho IketaniColumbia University Medical CenterVerified email at cumc.columbia.edu
James E. DiCarloVertex PharmaceuticalsVerified email at vrtx.com
Raj ChariLeidos Biomedical Research, Frederick National Lab for Cancer ResearchVerified email at nih.gov
Ron WeissProfessor of Biological Engineering, Massachusetts Institute of TechnologyVerified email at mit.edu
Mo EbrahimkhaniAssociate professor, Department of Pathology, University of PittsburghVerified email at pitt.edu
Kevin EsveltAssociate Professor, MIT Media LabVerified email at mit.edu
Stephen P. GoffProfessor of Biochemistry and Molecular Biophysics, Columbia UniversityVerified email at cumc.columbia.edu
Bruce CulbertsonMD/PhD candidate, Columbia UniversityVerified email at cumc.columbia.edu
Yosef SaboDepartment of Medicine / ADARC, Columbia UniversityVerified email at cumc.columbia.edu
Avinash BhandoolaLGI, NCI, NIHVerified email at nih.gov
Richard I. MorimotoBill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, NorthwesternVerified email at northwestern.edu
Ronald PlasterkVerified email at tiscali.nl

Alejandro Chavez

Associate Professor - University of California San Diego

Verified email at health.ucsd.edu - Homepage

Synthetic biology Genome engineering High-throughput Screening Neurodegenerative Disease


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Age-related clonal hematopoiesis associated with adverse outcomes S Jaiswal, P Fontanillas, J Flannick, A Manning, PV Grauman, BG Mar, ... New England Journal of Medicine 371 (26), 2488-2498, 2014	4549	2014
Highly efficient Cas9-mediated transcriptional programming A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, ... Nature methods 12 (4), 326-328, 2015	1647	2015
Comparison of Cas9 activators in multiple species A Chavez, M Tuttle, BW Pruitt, B Ewen-Campen, R Chari, ... Nature methods 13 (7), 563-567, 2016	579	2016
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ... Proceedings of the National Academy of Sciences of the United States of …, 2004	515	2004
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ... Nature microbiology 2 (4), 1-9, 2017	483	2017
An enhanced CRISPR repressor for targeted mammalian gene regulation NC Yeo, A Chavez, A Lance-Byrne, Y Chan, D Menn, D Milanova, ... Nature methods 15 (8), 611-616, 2018	473	2018
A critical role for TCF-1 in T-lineage specification and differentiation BN Weber, AWS Chi, A Chavez, Y Yashiro-Ohtani, Q Yang, O Shestova, ... Nature 476 (7358), 63-68, 2011	455	2011
Safeguarding CRISPR-Cas9 gene drives in yeast JE DiCarlo, A Chavez, SL Dietz, KM Esvelt, GM Church Nature biotechnology 33 (12), 1250-1255, 2015	396	2015
Cas9 gRNA engineering for genome editing, activation and repression S Kiani, A Chavez, M Tuttle, RN Hall, R Chari, D Ter-Ovanesyan, J Qian, ... Nature methods 12 (11), 1051-1054, 2015	365	2015
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance AC Bester, JD Lee, A Chavez, YR Lee, D Nachmani, S Vora, J Victor, ... Cell 173 (3), 649-664. e20, 2018	297	2018
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir S Iketani, H Mohri, B Culbertson, SJ Hong, Y Duan, MI Luck, ... Nature 613 (7944), 558-564, 2023	255	2023
Daisy-chain gene drives for the alteration of local populations C Noble, J Min, J Olejarz, J Buchthal, A Chavez, AL Smidler, ... Proceedings of the National Academy of Sciences 116 (17), 8275-8282, 2019	247	2019
sgRNA Scorer 2.0: A species-independent model to predict CRISPR/Cas9 activity R Chari, NC Yeo, A Chavez, GM Church ACS synthetic biology 6 (5), 902-904, 2017	229	2017
A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans RS Shapiro, A Chavez, CBM Porter, M Hamblin, CS Kaas, JE DiCarlo, ... Nature microbiology 3 (1), 73-82, 2018	154	2018
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks R Clarke, R Heler, MS MacDougall, NC Yeo, A Chavez, M Regan, ... Molecular cell 71 (1), 42-55. e8, 2018	152	2018
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors S Iketani, F Forouhar, H Liu, SJ Hong, FY Lin, MS Nair, A Zask, Y Huang, ... Nature communications 12 (1), 2016, 2021	110	2021
CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms RS Shapiro, A Chavez, JJ Collins Nature Reviews Microbiology 16 (6), 333-339, 2018	103	2018
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence JM Platt, P Ryvkin, JJ Wanat, G Donahue, MD Ricketts, SP Barrett, ... Genes & development 27 (12), 1406-1420, 2013	96	2013
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast X Guo, A Chavez, A Tung, Y Chan, C Kaas, Y Yin, R Cecchi, SL Garnier, ... Nature biotechnology 36 (6), 540-546, 2018	95	2018
Mutant Cas9 proteins A Chavez, F Poelwijk, GM Church US Patent 9,074,199, 2015	78	2015

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