Thomas Hale Segall-Shapiro
Thomas Hale Segall-Shapiro
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Creation of a bacterial cell controlled by a chemically synthesized genome
DG Gibson, JI Glass, C Lartigue, VN Noskov, RY Chuang, MA Algire, ...
science 329 (5987), 52-56, 2010
Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors
AJ Meyer, TH Segall-Shapiro, E Glassey, J Zhang, CA Voigt
Nature chemical biology 15 (2), 196-204, 2019
Modular control of multiple pathways using engineered orthogonal T7 polymerases
K Temme, R Hill, TH Segall-Shapiro, F Moser, CA Voigt
Nucleic Acids Research, 2012
Design of orthogonal genetic switches based on a crosstalk map of σs, anti‐σs, and promoters
VA Rhodius, TH Segall‐Shapiro, BD Sharon, A Ghodasara, E Orlova, ...
Molecular systems biology 9 (1), 702, 2013
A ‘resource allocator’for transcription based on a highly fragmented T7 RNA polymerase
TH Segall‐Shapiro, AJ Meyer, AD Ellington, ED Sontag, CA Voigt
Molecular systems biology 10 (7), 742, 2014
Engineered promoters enable constant gene expression at any copy number in bacteria
TH Segall-Shapiro, ED Sontag, CA Voigt
Nature biotechnology 36 (4), 352-358, 2018
Advances in genetic circuit design: novel biochemistries, deep part mining, and precision gene expression
AAK Nielsen, TH Segall-Shapiro, CA Voigt
Current opinion in chemical biology 17 (6), 878-892, 2013
An adaptor from translational to transcriptional control enables predictable assembly of complex regulation
CC Liu, L Qi, JB Lucks, TH Segall-Shapiro, D Wang, VK Mutalik, AP Arkin
Nature Methods, 2012
Tandem repeat coupled with endonuclease cleavage (TREC): a seamless modification tool for genome engineering in yeast
VN Noskov, TH Segall-Shapiro, RY Chuang
Nucleic acids research 38 (8), 2570-2576, 2010
A genetically encoded and gate for cell-targeted metabolic labeling of proteins
A Mahdavi, TH Segall-Shapiro, S Kou, GA Jindal, KG Hoff, S Liu, ...
Journal of the American Chemical Society 135 (8), 2979-2982, 2013
TREC-IN: gene knock-in genetic tool for genomes cloned in yeast
S Chandran, VN Noskov, TH Segall-Shapiro, L Ma, C Whiteis, C Lartigue, ...
BMC genomics 15, 1-11, 2014
Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein
K Javanmardi, TH Segall-Shapiro, CW Chou, DR Boutz, RJ Olsen, X Xie, ...
Cell host & microbe 30 (9), 1242-1254. e6, 2022
Mesophilic and hyperthermophilic adenylate kinases differ in their tolerance to random fragmentation
TH Segall-Shapiro, PQ Nguyen, ED Dos Santos, S Subedi, J Judd, J Suh, ...
Journal of molecular biology 406 (1), 135-148, 2011
Selection for constrained peptides that bind to a single target protein
AM King, DA Anderson, E Glassey, TH Segall-Shapiro, Z Zhang, ...
Nature Communications 12 (1), 6343, 2021
The structure of a thermophilic kinase shapes fitness upon random circular permutation
AM Jones, MM Mehta, EE Thomas, JT Atkinson, TH Segall-Shapiro, S Liu, ...
ACS synthetic biology 5 (5), 415-425, 2016
Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality
J Goike, CL Hsieh, A Horton, EC Gardner, F Bartzoka, N Wang, ...
Biorxiv, 2021
SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode
J Goike, CL Hsieh, AP Horton, EC Gardner, L Zhou, F Bartzoka, N Wang, ...
Communications Biology 6 (1), 1250, 2023
TREC-IN: gene knock-in genetic tool for genomes cloned in yeast.
SC Suchismita Chandran, VN Noskov, TH Segall-Shapiro, ML Ma Li, ...
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