Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines SJ Kattman, AD Witty, M Gagliardi, NC Dubois, M Niapour, A Hotta, J Ellis, ... Cell stem cell 8 (2), 228-240, 2011 | 1343 | 2011 |
Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9 HL Li, N Fujimoto, N Sasakawa, S Shirai, T Ohkame, T Sakuma, ... Stem cell reports 4 (1), 143-154, 2015 | 645 | 2015 |
Targeted disruption of HLA genes via CRISPR-Cas9 generates iPSCs with enhanced immune compatibility H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, ... Cell Stem Cell 24 (4), 566-578. e7, 2019 | 428 | 2019 |
Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency A Hotta, AYL Cheung, N Farra, K Vijayaragavan, CA Séguin, JS Draper, ... Nature methods 6 (5), 370-376, 2009 | 372 | 2009 |
Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a nonhuman primate A Morizane, D Doi, T Kikuchi, K Okita, A Hotta, T Kawasaki, T Hayashi, ... Stem Cell Reports 1 (4), 283-292, 2013 | 312 | 2013 |
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation AYL Cheung, LM Horvath, D Grafodatskaya, P Pasceri, R Weksberg, ... Human molecular genetics 20 (11), 2103-2115, 2011 | 303 | 2011 |
Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro A Tanaka, K Woltjen, K Miyake, A Hotta, M Ikeya, T Yamamoto, T Nishino, ... PloS one 8 (4), e61540, 2013 | 246 | 2013 |
Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro A Tanaka, K Woltjen, K Miyake, A Hotta, M Ikeya, T Yamamoto, T Nishino, ... PLoS One 8 (4), e61540, 2013 | 246 | 2013 |
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis K Imamura, Y Izumi, A Watanabe, K Tsukita, K Woltjen, T Yamamoto, ... Science Translational Medicine 9 (391), eaaf3962, 2017 | 233 | 2017 |
Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping P Gee, MSY Lung, Y Okuzaki, N Sasakawa, T Iguchi, Y Makita, H Hozumi, ... Nature communications 11 (1), 1-18, 2020 | 230 | 2020 |
Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type W Rahmani, S Abbasi, A Hagner, E Raharjo, R Kumar, A Hotta, ... Developmental cell 31 (5), 543-558, 2014 | 228 | 2014 |
Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states A Hotta, J Ellis Journal of cellular biochemistry 105 (4), 940-948, 2008 | 215 | 2008 |
Constitutive heterochromatin reorganization during somatic cell reprogramming E Fussner, U Djuric, M Strauss, A Hotta, C Perez‐Iratxeta, F Lanner, ... The EMBO journal 30 (9), 1778-1789, 2011 | 169 | 2011 |
Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model IY Choi, HT Lim, K Estrellas, J Mula, TV Cohen, Y Zhang, CJ Donnelly, ... Cell reports 15 (10), 2301-2312, 2016 | 162 | 2016 |
Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells Y Kojima, K Sasaki, S Yokobayashi, Y Sakai, T Nakamura, Y Yabuta, ... Cell Stem Cell 21 (4), 517-532. e5, 2017 | 157 | 2017 |
Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice T Kondo, M Funayama, K Tsukita, A Hotta, A Yasuda, S Nori, S Kaneko, ... Stem cell reports 3 (2), 242-249, 2014 | 155 | 2014 |
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells H Morisaka, K Yoshimi, Y Okuzaki, P Gee, Y Kunihiro, E Sonpho, H Xu, ... Nature communications 10 (1), 1-13, 2019 | 144 | 2019 |
From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing A Hotta, S Yamanaka Annual Review of Genetics 49, 47-70, 2015 | 136 | 2015 |
Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy A Minagawa, T Yoshikawa, M Yasukawa, A Hotta, M Kunitomo, S Iriguchi, ... Cell stem cell 23 (6), 850-858. e4, 2018 | 129 | 2018 |
Cell-type-specific genome editing with a microRNA-responsive CRISPR–Cas9 switch M Hirosawa, Y Fujita, CJC Parr, K Hayashi, S Kashida, A Hotta, K Woltjen, ... Nucleic acids research 45 (13), e118-e118, 2017 | 108 | 2017 |