| Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines SJ Kattman, AD Witty, M Gagliardi, NC Dubois, M Niapour, A Hotta, J Ellis, ... Cell stem cell 8 (2), 228-240, 2011 | 1381 | 2011 |
| Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9 HL Li, N Fujimoto, N Sasakawa, S Shirai, T Ohkame, T Sakuma, ... Stem cell reports 4 (1), 143-154, 2015 | 658 | 2015 |
| Targeted disruption of HLA genes via CRISPR-Cas9 generates iPSCs with enhanced immune compatibility H Xu, BO Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, ... Cell stem cell 24 (4), 566-578. e7, 2019 | 474 | 2019 |
| Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency A Hotta, AYL Cheung, N Farra, K Vijayaragavan, CA Séguin, JS Draper, ... Nature methods 6 (5), 370-376, 2009 | 378 | 2009 |
| Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a nonhuman primate A Morizane, D Doi, T Kikuchi, K Okita, A Hotta, T Kawasaki, T Hayashi, ... Stem cell reports 1 (4), 283-292, 2013 | 317 | 2013 |
| Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation AYL Cheung, LM Horvath, D Grafodatskaya, P Pasceri, R Weksberg, ... Human molecular genetics 20 (11), 2103-2115, 2011 | 307 | 2011 |
| Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping P Gee, MSY Lung, Y Okuzaki, N Sasakawa, T Iguchi, Y Makita, H Hozumi, ... Nature communications 11 (1), 1334, 2020 | 279 | 2020 |
| Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro A Tanaka, K Woltjen, K Miyake, A Hotta, M Ikeya, T Yamamoto, T Nishino, ... PloS one 8 (4), e61540, 2013 | 255 | 2013 |
| The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis K Imamura, Y Izumi, A Watanabe, K Tsukita, K Woltjen, T Yamamoto, ... Science Translational Medicine 9 (391), eaaf3962, 2017 | 252 | 2017 |
| Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type W Rahmani, S Abbasi, A Hagner, E Raharjo, R Kumar, A Hotta, ... Developmental cell 31 (5), 543-558, 2014 | 244 | 2014 |
| Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states A Hotta, J Ellis Journal of cellular biochemistry 105 (4), 940-948, 2008 | 221 | 2008 |
| Concordant but varied phenotypes among Duchenne muscular dystrophy patient-specific myoblasts derived using a human iPSC-based model IY Choi, HT Lim, K Estrellas, J Mula, TV Cohen, Y Zhang, CJ Donnelly, ... Cell reports 15 (10), 2301-2312, 2016 | 173 | 2016 |
| Constitutive heterochromatin reorganization during somatic cell reprogramming E Fussner, U Djuric, M Strauss, A Hotta, C Perez‐Iratxeta, F Lanner, ... The EMBO journal 30 (9), 1778-1789, 2011 | 173 | 2011 |
| CRISPR-Cas3 induces broad and unidirectional genome editing in human cells H Morisaka, K Yoshimi, Y Okuzaki, P Gee, Y Kunihiro, E Sonpho, H Xu, ... Nature communications 10 (1), 5302, 2019 | 166 | 2019 |
| Evolutionarily distinctive transcriptional and signaling programs drive human germ cell lineage specification from pluripotent stem cells Y Kojima, K Sasaki, S Yokobayashi, Y Sakai, T Nakamura, Y Yabuta, ... Cell stem cell 21 (4), 517-532. e5, 2017 | 165 | 2017 |
| Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice T Kondo, M Funayama, K Tsukita, A Hotta, A Yasuda, S Nori, S Kaneko, ... Stem cell reports 3 (2), 242-249, 2014 | 162 | 2014 |
| Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice E Kenjo, H Hozumi, Y Makita, KA Iwabuchi, N Fujimoto, S Matsumoto, ... Nature communications 12 (1), 7101, 2021 | 152 | 2021 |
| Enhancing T cell receptor stability in rejuvenated iPSC-derived T cells improves their use in cancer immunotherapy A Minagawa, T Yoshikawa, M Yasukawa, A Hotta, M Kunitomo, S Iriguchi, ... Cell Stem Cell 23 (6), 850-858. e4, 2018 | 143 | 2018 |
| From genomics to gene therapy: induced pluripotent stem cells meet genome editing A Hotta, S Yamanaka Annual review of genetics 49 (1), 47-70, 2015 | 142 | 2015 |
| Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges EA Taha, J Lee, A Hotta Journal of Controlled Release 342, 345-361, 2022 | 134 | 2022 |
James EllisThe Hospital for Sick ChildrenVerified email at Sickkids.ca
