| A presenilin dimer at the core of the γ-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis EH Schroeter, MXG Ilagan, AL Brunkan, S Hecimovic, Y Li, M Xu, ... Proceedings of the National Academy of Sciences 100 (22), 13075-13080, 2003 | 263 | 2003 |
| Phospholipids and Alzheimer’s disease: alterations, mechanisms and potential biomarkers M Kosicek, S Hecimovic International journal of molecular sciences 14 (1), 1310-1322, 2013 | 242 | 2013 |
| Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington’s disease gene carriers and healthy subjects: A cross-sectional study N Klepac, M Relja, R Klepac, S Hećimović, T Babić, V Trkulja Journal of neurology 254, 1676-1683, 2007 | 192 | 2007 |
| The low density lipoprotein receptor-related protein 1B retains β-amyloid precursor protein at the cell surface and reduces amyloid-β peptide production JA Cam, CV Zerbinatti, JM Knisely, S Hecimovic, Y Li, G Bu Journal of Biological Chemistry 279 (28), 29639-29646, 2004 | 132 | 2004 |
| Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease M Kosicek, H Zetterberg, N Andreasen, J Peter-Katalinic, S Hecimovic Neuroscience letters 516 (2), 302-305, 2012 | 108 | 2012 |
| Loss of cathepsin B and L leads to lysosomal dysfunction, NPC-like cholesterol sequestration and accumulation of the key Alzheimer's proteins S Cermak, M Kosicek, A Mladenovic-Djordjevic, K Smiljanic, S Kanazir, ... PLoS One 11 (11), e0167428, 2016 | 107 | 2016 |
| Mutations in APP have independent effects on Aβ and CTFγ generation S Hecimovic, J Wang, G Dolios, M Martinez, R Wang, AM Goate Neurobiology of disease 17 (2), 205-218, 2004 | 103 | 2004 |
| Bidirectional links between Alzheimer's disease and Niemann–Pick type C disease M Malnar, S Hecimovic, N Mattsson, H Zetterberg Neurobiology of disease 72, 37-47, 2014 | 88 | 2014 |
| Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts M Kosicek, M Malnar, A Goate, S Hecimovic Biochemical and biophysical research communications 393 (3), 404-409, 2010 | 87 | 2010 |
| Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes J Wang, AL Brunkan, S Hecimovic, E Walker, A Goate Neurobiology of disease 15 (3), 654-666, 2004 | 85 | 2004 |
| Nano-HPLC–MS analysis of phospholipids in cerebrospinal fluid of Alzheimer’s disease patients—a pilot study M Kosicek, S Kirsch, R Bene, Z Trkanjec, M Titlic, L Bindila, ... Analytical and bioanalytical chemistry 398, 2929-2937, 2010 | 77 | 2010 |
| Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia A Colombo, L Dinkel, SA Müller, L Sebastian Monasor, M Schifferer, ... Nature communications 12 (1), 1158, 2021 | 66 | 2021 |
| Expand long PCR for fragile X mutation detection S Hećimović, I Barišić, A Müller, I Petković, I Barić, I Ligutić, K Pavelić Clinical genetics 52 (3), 147-154, 1997 | 64 | 1997 |
| Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells M Malnar, M Kosicek, A Lisica, M Posavec, A Krolo, J Njavro, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (8 …, 2012 | 45 | 2012 |
| Amyloid-β metabolism in Niemann-Pick C disease models and patients N Mattsson, M Olsson, MK Gustavsson, M Kosicek, M Malnar, ... Metabolic brain disease 27, 573-585, 2012 | 44 | 2012 |
| Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway M Malnar, M Kosicek, S Mitterreiter, D Omerbasic, SF Lichtenthaler, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (7-8 …, 2010 | 44 | 2010 |
| Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation JM Ringman, KH Gylys, LD Medina, M Fox, V Kepe, DL Flores, ... Neuroscience letters 487 (3), 287-292, 2011 | 40 | 2011 |
| N-glycome of the lysosomal glycocalyx is altered in niemann-pick type C disease (NPC) model cells M Kosicek, I Gudelj, A Horvatic, T Jovic, F Vuckovic, G Lauc, S Hecimovic Molecular & cellular proteomics 17 (4), 631-642, 2018 | 35 | 2018 |
| Genetic background of huntington disease in Croatia: molecular analysis of CAG, CCG, and Δ2642 (E2642del) polymorphisms S Hećimović, N Klepac, J Vlašić, A Vojta, D Janko, I Škarpa‐Prpić, ... Human mutation 20 (3), 233-233, 2002 | 27 | 2002 |
| Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors KD Dražić T, Molčanov K, Sachdev V, Malnar M, Hecimovic S, Patankar JV ... European Journal of Medicinal Chemistry 87, 722-734, 2014 | 22 | 2014 |
