| A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity M Okada-Iwabu, T Yamauchi, M Iwabu, T Honma, K Hamagami, ... Nature 503 (7477), 493-499, 2013 | 780 | 2013 |
| Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: New de Novo Design Strategy and Library Design T Honma, K Hayashi, T Aoyama, N Hashimoto, T Machida, K Fukasawa, ... Journal of Medicinal Chemistry 44 (26), 4615-4627, 2001 | 331 | 2001 |
| Structure of the trypanosome cyanide-insensitive alternative oxidase T Shiba, Y Kido, K Sakamoto, DK Inaoka, C Tsuge, R Tatsumi, ... Proceedings of the National Academy of Sciences 110 (12), 4580-4585, 2013 | 216 | 2013 |
| A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues T Honma, T Yoshizumi, N Hashimoto, K Hayashi, N Kawanishi, ... Journal of medicinal chemistry 44 (26), 4628-4640, 2001 | 192 | 2001 |
| The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA S Iwasaki, W Iwasaki, M Takahashi, A Sakamoto, C Watanabe, Y Shichino, ... Molecular cell 73 (4), 738-748. e9, 2019 | 180 | 2019 |
| Structural basis for chemical inhibition of human blood coagulation factor Xa K Kamata, H Kawamoto, T Honma, T Iwama, SH Kim Proceedings of the National Academy of Sciences 95 (12), 6630-6635, 1998 | 170 | 1998 |
| Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein M Ikuta, K Kamata, K Fukasawa, T Honma, T Machida, H Hirai, ... Journal of Biological Chemistry 276 (29), 27548-27554, 2001 | 158 | 2001 |
| Practical synthesis of indolopyrrolocarbazoles M Ohkubo, T Nishimura, H Jona, T Honma, H Morishima Tetrahedron 52 (24), 8099-8112, 1996 | 150 | 1996 |
| Combining machine learning and pharmacophore-based interaction fingerprint for in silico screening T Sato, T Honma, S Yokoyama Journal of chemical information and modeling 50 (1), 170-185, 2010 | 148 | 2010 |
| Population-based de novo molecule generation, using grammatical evolution N Yoshikawa, K Terayama, M Sumita, T Homma, K Oono, K Tsuda Chemistry Letters 47 (11), 1431-1434, 2018 | 135 | 2018 |
| Predicting human liver microsomal stability with machine learning techniques Y Sakiyama, H Yuki, T Moriya, K Hattori, M Suzuki, K Shimada, T Honma Journal of molecular graphics and Modelling 26 (6), 907-915, 2008 | 110 | 2008 |
| A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo Y Saito, H Yuki, M Kuratani, Y Hashizume, S Takagi, T Honma, A Tanaka, ... Science translational medicine 5 (181), 181ra52-181ra52, 2013 | 101 | 2013 |
| Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2 A Nishikimi, T Uruno, X Duan, Q Cao, Y Okamura, T Saitoh, N Saito, ... Chemistry & biology 19 (4), 488-497, 2012 | 100 | 2012 |
| Recent advances in de novo design strategy for practical lead identification T Honma Medicinal research reviews 23 (5), 606-632, 2003 | 89 | 2003 |
| kGCN: a graph-based deep learning framework for chemical structures R Kojima, S Ishida, M Ohta, H Iwata, T Honma, Y Okuno Journal of Cheminformatics 12, 1-10, 2020 | 82 | 2020 |
| Structural insights into the molecular design of flutolanil derivatives targeted for fumarate respiration of parasite mitochondria DK Inaoka, T Shiba, D Sato, EO Balogun, T Sasaki, M Nagahama, M Oda, ... International journal of molecular sciences 16 (7), 15287-15308, 2015 | 82 | 2015 |
| Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK1 H Tajiri, T Uruno, T Shirai, D Takaya, S Matsunaga, D Setoyama, ... Cell reports 19 (5), 969-980, 2017 | 78 | 2017 |
| Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase H Shimizu, A Saito, J Mikuni, EE Nakayama, H Koyama, T Honma, ... PLoS neglected tropical diseases 13 (11), e0007894, 2019 | 73 | 2019 |
| Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II K Ogura, T Sato, H Yuki, T Honma Scientific reports 9 (1), 12220, 2019 | 56 | 2019 |
| Total synthesis of (+)-obtusenyne K Fujiwara, D Awakura, M Tsunashima, A Nakamura, T Honma, A Murai The Journal of Organic Chemistry 64 (8), 2616-2617, 1999 | 56 | 1999 |
