| Metal ions as modulators of protein conformation and misfolding in neurodegeneration SS Leal, HM Botelho, CM Gomes Coordination Chemistry Reviews 256 (19-20), 2253-2270, 2012 | 172 | 2012 |
| Natural and amyloid self‐assembly of S100 proteins: structural basis of functional diversity G Fritz, HM Botelho, LA Morozova‐Roche, CM Gomes The FEBS journal 277 (22), 4578-4590, 2010 | 151 | 2010 |
| Correction of a cystic fibrosis splicing mutation by antisense oligonucleotides S Igreja, LA Clarke, HM Botelho, L Marques, MD Amaral Human mutation 37 (2), 209-215, 2016 | 86 | 2016 |
| Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery HM Botelho, I Uliyakina, NT Awatade, MC Proença, C Tischer, L Sirianant, ... Scientific reports 5 (1), 9038, 2015 | 73 | 2015 |
| The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation JS Cristóvão, VK Morris, I Cardoso, SS Leal, J Martínez, HM Botelho, ... Science advances 4 (6), eaaq1702, 2018 | 65 | 2018 |
| Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators LA Clarke, HM Botelho, L Sousa, AO Falcao, MD Amaral Genomics 106 (5), 268-277, 2015 | 46 | 2015 |
| S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation HM Botelho, SS Leal, I Cardoso, K Yanamandra, LA Morozova-Roche, ... Journal of Biological Chemistry 287 (50), 42233-42242, 2012 | 43 | 2012 |
| Metal ions modulate the folding and stability of the tumor suppressor protein S100A2 HM Botelho, M Koch, G Fritz, CM Gomes The FEBS journal 276 (6), 1776-1786, 2009 | 42 | 2009 |
| R560S: a class II CFTR mutation that is not rescued by current modulators NT Awatade, S Ramalho, IAL Silva, V Felício, HM Botelho, E de Poel, ... Journal of Cystic Fibrosis 18 (2), 182-189, 2019 | 34 | 2019 |
| Intrinsically Disordered and Aggregation Prone Regions Underlie β-Aggregation in S100 Proteins CMG SB Carvalho, HM Botelho, SS Leal, I Cardoso, G PLoS One 8, e76629, 2013 | 32 | 2013 |
| The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme A Veith, HM Botelho, F Kindinger, CM Gomes, A Kletzin Journal of bacteriology 194 (3), 677-685, 2012 | 32 | 2012 |
| A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic JR Lérias, MC Pinto, HM Botelho, NT Awatade, MC Quaresma, IAL Silva, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (2), 421-431, 2018 | 31 | 2018 |
| Analysis of S100 oligomers and amyloids HM Botelho, G Fritz, CM Gomes Amyloid Proteins: Methods and Protocols, 373-386, 2012 | 31 | 2012 |
| CFTR processing, trafficking and interactions MD Amaral, DM Hutt, V Tomati, HM Botelho, N Pedemonte Journal of Cystic Fibrosis 19, S33-S36, 2020 | 25 | 2020 |
| Biochemical and biophysical characterization of recombinant yeast proteasome maturation factor Ump1 B Sá-Moura, AM Simões, J Fraga, H Fernandes, IA Abreu, HM Botelho, ... Computational and structural biotechnology journal 7 (8), e201304006, 2013 | 25 | 2013 |
| Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum JD Santos, S Canato, AS Carvalho, HM Botelho, K Aloria, MD Amaral, ... Cells 8 (4), 353, 2019 | 23 | 2019 |
| CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system SH Lim, J Snider, L Birimberg‐Schwartz, W Ip, JC Serralha, HM Botelho, ... Molecular Systems Biology 18 (2), e10629, 2022 | 22 | 2022 |
| A proteomic approach toward the selection of proteins with enhanced intrinsic conformational stability V Prosinecki, HM Botelho, S Francese, G Mastrobuoni, G Moneti, T Urich, ... Journal of proteome research 5 (10), 2720-2726, 2006 | 17 | 2006 |
| Investigating alternative transport of integral plasma membrane proteins from the er to the golgi: lessons from the cystic fibrosis transmembrane conductance regulator (CFTR) MD Amaral, CM Farinha, P Matos, HM Botelho Unconventional Protein Secretion: Methods and Protocols, 105-126, 2016 | 13 | 2016 |
| Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A> G IAL Silva, T Doušová, S Ramalho, R Centeio, LA Clarke, V Railean, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (11), 165905, 2020 | 12 | 2020 |
Margarida AmaralProfessor of Molecular Biology, Faculty of Sciences, University of LisboaVerified email at fc.ul.pt
