フォロー
Shusuke Tomoshige
Shusuke Tomoshige
Graduate School of Life Sciences, Tohoku University
確認したメール アドレス: tohoku.ac.jp - ホームページ
タイトル
引用先
引用先
Discovery of small molecules that induce the degradation of huntingtin
S Tomoshige, S Nomura, K Ohgane, Y Hashimoto, M Ishikawa
Angewandte Chemie International Edition 56 (38), 11530-11533, 2017
1122017
Proximity histidine labeling by umpolung strategy using singlet oxygen
K Nakane, S Sato, T Niwa, M Tsushima, S Tomoshige, H Taguchi, ...
Journal of the American Chemical Society 143 (20), 7726-7731, 2021
652021
Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules
S Tomoshige, M Naito, Y Hashimoto, M Ishikawa
Organic & biomolecular chemistry 13 (38), 9746-9750, 2015
612015
Structure–activity relationships of bisphenol A analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist
K Maruyama, M Nakamura, S Tomoshige, K Sugita, M Makishima, ...
Bioorganic & medicinal chemistry letters 23 (14), 4031-4036, 2013
612013
PROTACs and other chemical protein degradation technologies for the treatment of neurodegenerative disorders
S Tomoshige, M Ishikawa
Angewandte Chemie International Edition 60 (7), 3346-3354, 2021
562021
Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand
S Tomoshige, Y Hashimoto, M Ishikawa
Bioorganic & medicinal chemistry 24 (14), 3144-3148, 2016
422016
Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa
M Lee, MT Batuecas, S Tomoshige, T Domínguez-Gil, KV Mahasenan, ...
Proceedings of the National Academy of Sciences 115 (17), 4393-4398, 2018
392018
Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative
S Tomoshige, S Nomura, K Ohgane, Y Hashimoto, M Ishikawa
Bioorganic & medicinal chemistry letters 28 (4), 707-710, 2018
372018
Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics
DA Dik, CS Madukoma, S Tomoshige, C Kim, E Lastochkin, WC Boggess, ...
ACS chemical biology 14 (2), 296-303, 2019
362019
Total syntheses of bulgecins A, B, and C and their bactericidal potentiation of the β-lactam antibiotics
S Tomoshige, DA Dik, M Akabane-Nakata, CS Madukoma, JF Fisher, ...
ACS Infectious Diseases 4 (6), 860-867, 2018
312018
Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins
H Yamashita, S Tomoshige, S Nomura, K Ohgane, Y Hashimoto, ...
Bioorganic & Medicinal Chemistry 28 (1), 115175, 2020
202020
Selective degradation of target proteins by chimeric small-molecular drugs, PROTACs and SNIPERs
M Ishikawa, S Tomoshige, Y Demizu, M Naito
Pharmaceuticals 13 (4), 74, 2020
192020
Synthesis, antibacterial and cytotoxic evaluation of flavipucine and its derivatives
Y Kusakabe, S Mizutani, S Kamo, T Yoshimoto, S Tomoshige, T Kawasaki, ...
Bioorganic & Medicinal Chemistry Letters 29 (11), 1390-1394, 2019
172019
Conversion of a PROTAC mutant huntingtin degrader into small-molecule hydrophobic tags focusing on drug-like properties
K Hirai, H Yamashita, S Tomoshige, Y Mishima, T Niwa, K Ohgane, M Ishii, ...
ACS Medicinal Chemistry Letters 13 (3), 396-402, 2022
152022
Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum
S Oka, R Kuniba, N Tsuboi, S Tsuchida, K Ushida, S Tomoshige, ...
Bioscience, biotechnology, and biochemistry 84 (1), 31-36, 2020
142020
BODIPY Catalyzes Proximity‐Dependent Histidine Labelling
K Nakane, T Niwa, M Tsushima, S Tomoshige, H Taguchi, H Nakamura, ...
ChemCatChem 14 (9), e202200077, 2022
132022
Total syntheses of pyocyanin, lavanducyanin, and marinocyanins A and B
H Kohatsu, S Kamo, S Tomoshige, K Kuramochi
Organic letters 21 (18), 7311-7314, 2019
132019
Improvement in aqueous solubility of retinoic acid receptor (RAR) agonists by bending the molecular structure
M Hiramatsu, Y Ichikawa, S Tomoshige, M Makishima, A Muranaka, ...
Chemistry–An Asian Journal 11 (15), 2210-2217, 2016
122016
Switching of photocatalytic tyrosine/histidine labeling and application to photocatalytic proximity labeling
K Nakane, H Nagasawa, C Fujimura, E Koyanagi, S Tomoshige, ...
International Journal of Molecular Sciences 23 (19), 11622, 2022
102022
Synthesis and antiviral activities of neoechinulin B and its derivatives
K Nishiuchi, H Ohashi, K Nishioka, M Yamasaki, M Furuta, T Mashiko, ...
Journal of Natural Products 85 (1), 284-291, 2021
82021
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