| Discovery of small molecules that induce the degradation of huntingtin S Tomoshige, S Nomura, K Ohgane, Y Hashimoto, M Ishikawa Angewandte Chemie International Edition 56 (38), 11530-11533, 2017 | 129 | 2017 |
| Proximity histidine labeling by umpolung strategy using singlet oxygen K Nakane, S Sato, T Niwa, M Tsushima, S Tomoshige, H Taguchi, ... Journal of the American Chemical Society 143 (20), 7726-7731, 2021 | 78 | 2021 |
| Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules S Tomoshige, M Naito, Y Hashimoto, M Ishikawa Organic & biomolecular chemistry 13 (38), 9746-9750, 2015 | 67 | 2015 |
| PROTACs and other chemical protein degradation technologies for the treatment of neurodegenerative disorders S Tomoshige, M Ishikawa Angewandte Chemie International Edition 60 (7), 3346-3354, 2021 | 66 | 2021 |
| Structure–activity relationships of bisphenol A analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist K Maruyama, M Nakamura, S Tomoshige, K Sugita, M Makishima, ... Bioorganic & medicinal chemistry letters 23 (14), 4031-4036, 2013 | 65 | 2013 |
| Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand S Tomoshige, Y Hashimoto, M Ishikawa Bioorganic & medicinal chemistry 24 (14), 3144-3148, 2016 | 47 | 2016 |
| Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative S Tomoshige, S Nomura, K Ohgane, Y Hashimoto, M Ishikawa Bioorganic & Medicinal Chemistry Letters 28 (4), 707-710, 2018 | 44 | 2018 |
| Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa M Lee, MT Batuecas, S Tomoshige, T Domínguez-Gil, KV Mahasenan, ... Proceedings of the National Academy of Sciences 115 (17), 4393-4398, 2018 | 43 | 2018 |
| Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics DA Dik, CS Madukoma, S Tomoshige, C Kim, E Lastochkin, WC Boggess, ... ACS chemical biology 14 (2), 296-303, 2019 | 41 | 2019 |
| Total syntheses of bulgecins A, B, and C and their bactericidal potentiation of the β-lactam antibiotics S Tomoshige, DA Dik, M Akabane-Nakata, CS Madukoma, JF Fisher, ... ACS Infectious Diseases 4 (6), 860-867, 2018 | 32 | 2018 |
| Conversion of a PROTAC mutant huntingtin degrader into small-molecule hydrophobic tags focusing on drug-like properties K Hirai, H Yamashita, S Tomoshige, Y Mishima, T Niwa, K Ohgane, M Ishii, ... ACS Medicinal Chemistry Letters 13 (3), 396-402, 2022 | 23 | 2022 |
| Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins H Yamashita, S Tomoshige, S Nomura, K Ohgane, Y Hashimoto, ... Bioorganic & Medicinal Chemistry 28 (1), 115175, 2020 | 22 | 2020 |
| Selective degradation of target proteins by chimeric small-molecular drugs, PROTACs and SNIPERs M Ishikawa, S Tomoshige, Y Demizu, M Naito Pharmaceuticals 13 (4), 74, 2020 | 20 | 2020 |
| Total syntheses of pyocyanin, lavanducyanin, and marinocyanins A and B H Kohatsu, S Kamo, S Tomoshige, K Kuramochi Organic letters 21 (18), 7311-7314, 2019 | 17 | 2019 |
| Synthesis, antibacterial and cytotoxic evaluation of flavipucine and its derivatives Y Kusakabe, S Mizutani, S Kamo, T Yoshimoto, S Tomoshige, T Kawasaki, ... Bioorganic & Medicinal Chemistry Letters 29 (11), 1390-1394, 2019 | 17 | 2019 |
| Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum S Oka, R Kuniba, N Tsuboi, S Tsuchida, K Ushida, S Tomoshige, ... Bioscience, biotechnology, and biochemistry 84 (1), 31-36, 2020 | 16 | 2020 |
| Synthesis and Cytotoxic Evaluation of N-Alkyl-2-halophenazin-1-ones H Kohatsu, S Kamo, M Furuta, S Tomoshige, K Kuramochi ACS omega 5 (42), 27667-27674, 2020 | 15 | 2020 |
| BODIPY Catalyzes Proximity‐Dependent Histidine Labelling K Nakane, T Niwa, M Tsushima, S Tomoshige, H Taguchi, H Nakamura, ... ChemCatChem 14 (9), e202200077, 2022 | 14 | 2022 |
| Synthesis and antiviral activities of neoechinulin B and its derivatives K Nishiuchi, H Ohashi, K Nishioka, M Yamasaki, M Furuta, T Mashiko, ... Journal of Natural Products 85 (1), 284-291, 2021 | 12 | 2021 |
| Improvement in aqueous solubility of retinoic acid receptor (RAR) agonists by bending the molecular structure M Hiramatsu, Y Ichikawa, S Tomoshige, M Makishima, A Muranaka, ... Chemistry–An Asian Journal 11 (15), 2210-2217, 2016 | 12 | 2016 |
Shinichi SatoTohoku UniversityVerified email at tohoku.ac.jp
