Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone: Reversed binding orientations in different redox states of the enzyme PR Race, AL Lovering, RM Green, A Ossor, SA White, PF Searle, ... Journal of Biological Chemistry 280 (14), 13256-13264, 2005 | 241 | 2005 |
Nitroreductase: a prodrug-activating enzyme for cancer gene therapy. PF Searle, MJ Chen, L Hu, PR Race, AL Lovering, JI Grove, C Guise, ... Clinical & Experimental Pharmacology & Physiology 31 (11), 2004 | 142 | 2004 |
The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution AL Lovering, EI Hyde, PF Searle, SA White Journal of molecular biology 309 (1), 203-213, 2001 | 137 | 2001 |
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy L Hu, C Yu, Y Jiang, J Han, Z Li, P Browne, PR Race, RJ Knox, PF Searle, ... Journal of medicinal chemistry 46 (23), 4818-4821, 2003 | 95 | 2003 |
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954 PR Race, AL Lovering, SA White, JI Grove, PF Searle, CW Wrighton, ... Journal of molecular biology 368 (2), 481-492, 2007 | 94 | 2007 |
Generation of Escherichia Coli Nitroreductase Mutants Conferring Improved Cell Sensitization to the Prodrug CB1954 JI Grove, AL Lovering, C Guise, PR Race, CJ Wrighton, SA White, EI Hyde, ... Cancer research 63 (17), 5532-5537, 2003 | 92 | 2003 |
Proton nuclear magnetic resonance saturation transfer studies of coenzyme binding to Lactobacillus casei dihydrofolate reductase EI Hyde, B Birdsall, GCK Roberts, J Feeney, ASV Burgen Biochemistry 19 (16), 3738-3746, 1980 | 87* | 1980 |
A simple mechanism for co‐dependence on two activators at an Escherichia coli promoter JT Wade, TA Belyaeva, EI Hyde, SJW Busby The EMBO Journal, 2001 | 83 | 2001 |
E. coli NfsA: an alternative nitroreductase for prodrug activation gene therapy in combination with CB1954 SO Vass, D Jarrom, WR Wilson, EI Hyde, PF Searle British journal of cancer 100 (12), 1903-1911, 2009 | 78 | 2009 |
Proton NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements T Härd, E Kellenbach, R Boelens, K Dahlman, J Carlstedt-Duke, ... Biochemistry 29 (38), 9015-9023, 1990 | 74 | 1990 |
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin MJ Sutcliffe, M Jaseja, EI Hyde, X Lu, JA Williams Nature Structural Biology 1 (11), 802-807, 1994 | 70 | 1994 |
Three‐dimensional structure of the RGD‐containing snake toxin albolabrin in solution, based on 1H NMR spectroscopy and simulated annealing calculations KJ SMITH, M JASEJA, X LU, JA WILLIAMS, EVAI HYDE, IANP TRAYER International Journal of Peptide and Protein Research 48 (3), 220-228, 1996 | 60 | 1996 |
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the … KJ Smith, GS Baillie, EI Hyde, X Li, TM Houslay, A McCahill, AJ Dunlop, ... Cellular signalling 19 (12), 2612-2624, 2007 | 57 | 2007 |
Transcription activation at the Escherichia coli melAB promoter: the role of MelR and the cyclic AMP receptor protein TA Belyaeva, JT Wade, CL Webster, VJ Howard, MS Thomas, EI Hyde, ... Molecular Microbiology 36 (1), 211-222, 2000 | 56 | 2000 |
Steady-State and Stopped-Flow Kinetic Studies of Three Escherichia coli NfsB Mutants with Enhanced Activity for the Prodrug CB1954 D Jarrom, M Jaberipour, CP Guise, S Daff, SA White, PF Searle, EI Hyde Biochemistry 48 (32), 7665-7672, 2009 | 53 | 2009 |
Negative cooperativity between folinic acid and coenzyme in their binding to L. casei dihydrofolate reductase B Birdsall, ASV Burgen, EI Hyde, GCK Roberts, J Feeney Biochemistry 20 (25), 7186-7195, 1981 | 46 | 1981 |
Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations M Jaberipour, SO Vass, CP Guise, JI Grove, RJ Knox, L Hu, EI Hyde, ... Biochemical pharmacology 79 (2), 102-111, 2010 | 43 | 2010 |
1H and 31P NMR characterization of two conformations of the trimethoprim-NADP+-dihydrofolate reductase complex A GRONENBORN, B BIRDSALL, EVA HYDE, G ROBERTS, J FEENEY, ... Molecular Pharmacology 20 (1), 145-153, 1981 | 43 | 1981 |
Transcription activation at the Escherichia coli melAB promoter: interactions of MelR with its DNA target site and with domain 4 of the RNA polymerase σ subunit DC Grainger, CL Webster, TA Belyaeva, EI Hyde, SJW Busby Molecular microbiology 51 (5), 1297-1309, 2004 | 41 | 2004 |
Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and maltokinase Pep2 R Roy, V Usha, A Kermani, DJ Scott, EI Hyde, GS Besra, LJ Alderwick, ... ACS chemical biology 8 (10), 2245-2255, 2013 | 39 | 2013 |