| Recent developments of the chemistry development kit (CDK)-an open-source java library for chemo-and bioinformatics C Steinbeck, C Hoppe, S Kuhn, M Floris, R Guha, EL Willighagen Current pharmaceutical design 12 (17), 2111-2120, 2006 | 487 | 2006 |
| The Blue Obelisk—interoperability in chemical informatics R Guha, MT Howard, GR Hutchison, P Murray-Rust, H Rzepa, ... Journal of chemical information and modeling 46 (3), 991-998, 2006 | 476 | 2006 |
| Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma Y Yang, AL Shaffer III, NCT Emre, M Ceribelli, M Zhang, G Wright, W Xiao, ... Cancer cell 21 (6), 723-737, 2012 | 448 | 2012 |
| High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells LAM Griner, R Guha, P Shinn, RM Young, JM Keller, D Liu, IS Goldlust, ... Proceedings of the National Academy of Sciences 111 (6), 2349-2354, 2014 | 303 | 2014 |
| Structure− activity landscape index: identifying and quantifying activity cliffs R Guha, JH Van Drie Journal of chemical information and modeling 48 (3), 646-658, 2008 | 274 | 2008 |
| High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy SA Hasson, LA Kane, K Yamano, CH Huang, DA Sliter, E Buehler, ... Nature 504 (7479), 291-295, 2013 | 267 | 2013 |
| Chemical informatics functionality in R R Guha J Stat Softw 18 (5), 1-16, 2007 | 189 | 2007 |
| What are we ‘tweeting’about obesity? Mapping tweets with topic modeling and Geographic Information System D Ghosh, R Guha Cartography and geographic information science 40 (2), 90-102, 2013 | 186 | 2013 |
| The Chemistry Development Kit (CDK) v2. 0: atom typing, depiction, molecular formulas, and substructure searching EL Willighagen, JW Mayfield, J Alvarsson, A Berg, L Carlsson, ... Journal of cheminformatics 9 (1), 1-19, 2017 | 182 | 2017 |
| Open source drug discovery with the malaria box compound collection for neglected diseases and beyond WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ... PLoS Pathog 12 (7), e1005763, 2016 | 179 | 2016 |
| Navigating structure–activity landscapes J Bajorath, L Peltason, M Wawer, R Guha, MS Lajiness, JH Van Drie Drug discovery today 14 (13-14), 698-705, 2009 | 155 | 2009 |
| PubChem as a source of polypharmacology B Chen, D Wild, R Guha Journal of chemical information and modeling 49 (9), 2044-2055, 2009 | 153 | 2009 |
| Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors M Ceribelli, PN Kelly, AL Shaffer, GW Wright, W Xiao, Y Yang, LAM Griner, ... Proceedings of the National Academy of Sciences 111 (31), 11365-11370, 2014 | 151 | 2014 |
| Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome GW Rhyasen, L Bolanos, J Fang, A Jerez, M Wunderlich, C Rigolino, ... Cancer cell 24 (1), 90-104, 2013 | 150 | 2013 |
| Unexplored therapeutic opportunities in the human genome TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ... Nature reviews Drug discovery 17 (5), 317, 2018 | 144 | 2018 |
| RNA polymerase II regulates topoisomerase 1 activity to favor efficient transcription L Baranello, D Wojtowicz, K Cui, BN Devaiah, HJ Chung, KY Chan-Salis, ... Cell 165 (2), 357-371, 2016 | 143 | 2016 |
| Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets J Yuan, KCC Cheng, RL Johnson, R Huang, S Pattaradilokrat, A Liu, ... Science 333 (6043), 724-729, 2011 | 139 | 2011 |
| Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository N Singh, R Guha, MA Giulianotti, C Pinilla, RA Houghten, ... Journal of chemical information and modeling 49 (4), 1010-1024, 2009 | 139 | 2009 |
| Pharos: collating protein information to shed light on the druggable genome DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, ... Nucleic acids research 45 (D1), D995-D1002, 2017 | 131 | 2017 |
| ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses R Jossé, SE Martin, R Guha, P Ormanoglu, TD Pfister, PM Reaper, ... Cancer research 74 (23), 6968-6979, 2014 | 119 | 2014 |
Marc FerrerTeam Lead, NIHVerified email at mail.nih.gov
