| Requirement of caspase-3 (-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs S Simizu, M Takada, K Umezawa, M Imoto Journal of Biological Chemistry 273 (41), 26900-26907, 1998 | 322 | 1998 |
| Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions N Kanoh, S Kumashiro, S Simizu, Y Kondoh, S Hatakeyama, H Tashiro, ... Angewandte Chemie-International Edition 42 (45), 5584-5587, 2003 | 214 | 2003 |
| Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines S Simizu, H Osada Nature cell biology 2 (11), 852-854, 2000 | 160 | 2000 |
| Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics N Kanoh, K Honda, S Simizu, M Muroi, H Osada Angewandte Chemie-International Edition 44 (23), 3559-3562, 2005 | 150 | 2005 |
| The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria Y Tamura, S Simizu, H Osada FEBS letters 569 (1-3), 249-255, 2004 | 148 | 2004 |
| RECK negatively regulates matrix metalloproteinase-9 transcription S Takagi, S Simizu, H Osada Cancer research 69 (4), 1502-1508, 2009 | 130 | 2009 |
| Heparanase as a molecular target of cancer chemotherapy S Simizu, K Ishida, H Osada Cancer science 95 (7), 553-558, 2004 | 116 | 2004 |
| A small-molecule inhibitor shows that pirin regulates migration of melanoma cells I Miyazaki, S Simizu, H Okumura, S Takagi, H Osada Nature chemical biology 6 (9), 667-673, 2010 | 113 | 2010 |
| Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120 MMG Khan, S Simizu, NS Lai, M Kawatani, T Shimizu, H Osada ACS chemical biology 6 (3), 245-251, 2011 | 82 | 2011 |
| Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines S Simizu, K Ishida, MK Wierzba, H Osada Journal of Biological Chemistry 279 (4), 2697-2703, 2004 | 82 | 2004 |
| Photo‐Cross‐Linked Small‐Molecule Microarrays as Chemical Genomic Tools for Dissecting Protein–Ligand Interactions N Kanoh, A Asami, M Kawatani, K Honda, S Kumashiro, H Takayama, ... Chemistry–An Asian Journal 1 (6), 789-797, 2006 | 81 | 2006 |
| Synthesis of (+)-vinblastine and its analogues T Miyazaki, S Yokoshima, S Simizu, H Osada, H Tokuyama, T Fukuyama Organic Letters 9 (23), 4737-4740, 2007 | 75 | 2007 |
| RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines S Simizu, S Takagi, Y Tamura, H Osada Cancer research 65 (16), 7455-7461, 2005 | 70 | 2005 |
| Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion N Miyanishi, Y Suzuki, S Simizu, Y Kuwabara, K Banno, K Umezawa Biochemical and Biophysical Research Communications 403 (1), 154-159, 2010 | 67 | 2010 |
| Structure-based design of a selective heparanase inhibitor as an antimetastatic agent K Ishida, G Hirai, K Murakami, T Teruya, S Simizu, M Sodeoka, H Osada Molecular cancer therapeutics 3 (9), 1069-1077, 2004 | 67 | 2004 |
| Expression of heparanase in human tumor cell lines and human head and neck tumors S Simizu, K Ishida, MK Wierzba, TA Sato, H Osada Cancer letters 193 (1), 83-89, 2003 | 65 | 2003 |
| Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer H Mizuta, K Okada, M Araki, J Adachi, A Takemoto, J Kutkowska, ... Nature communications 12 (1), 1261, 2021 | 64 | 2021 |
| Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells S Simizu, M Imoto, N Masuda, M Takada, K Umezawa Cancer research 56 (21), 4978-4982, 1996 | 64 | 1996 |
| Involvement of disulfide bond formation in the activation of heparanase S Simizu, T Suzuki, M Muroi, NS Lai, S Takagi, N Dohmae, H Osada Cancer Research 67 (16), 7841-7849, 2007 | 58 | 2007 |
| Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway M Kondoh, I Suzuki, M Sato, F Nagashima, S Simizu, M Harada, M Fujii, ... Journal of Pharmacology and Experimental Therapeutics 311 (1), 115-122, 2004 | 58 | 2004 |
