|Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism|
SB Prusiner, AL Woerman, DA Mordes, JC Watts, R Rampersaud, ...
Proceedings of the National Academy of Sciences 112 (38), E5308-E5317, 2015
|Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions|
J Stöhr, JC Watts, ZL Mensinger, A Oehler, SK Grillo, SJ DeArmond, ...
Proceedings of the National Academy of Sciences, 2012
|Transmission of multiple system atrophy prions to transgenic mice|
JC Watts, K Giles, A Oehler, L Middleton, DT Dexter, SM Gentleman, ...
Proceedings of the National Academy of Sciences 110 (48), 19555-19560, 2013
|Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients|
JC Watts, C Condello, J Stöhr, A Oehler, J Lee, SJ DeArmond, L Lannfelt, ...
Proceedings of the National Academy of Sciences 111 (28), 10323-10328, 2014
|The in vivo brain interactome of the amyloid precursor protein|
Y Bai, K Markham, F Chen, R Weerasekera, J Watts, P Horne, Y Wakutani, ...
Molecular & Cellular Proteomics 7 (1), 15-34, 2008
|Propagation of prions causing synucleinopathies in cultured cells|
AL Woerman, J Stöhr, A Aoyagi, R Rampersaud, Z Krejciova, JC Watts, ...
Proceedings of the National Academy of Sciences 112 (35), E4949-E4958, 2015
|The expanding universe of prion diseases|
JC Watts, A Balachandran, D Westaway
PLoS pathogens 2 (3), e26, 2006
|The CNS glycoprotein Shadoo has PrPC‐like protective properties and displays reduced levels in prion infections|
JC Watts, B Drisaldi, V Ng, J Yang, B Strome, P Horne, MS Sy, L Yoong, ...
The EMBO journal 26 (17), 4038-4050, 2007
|Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice|
J Stöhr, C Condello, JC Watts, L Bloch, A Oehler, M Nick, SJ DeArmond, ...
Proceedings of the National Academy of Sciences 111 (28), 10329-10334, 2014
|The prion protein family: diversity, rivalry, and dysfunction|
JC Watts, D Westaway
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1772 (6), 654-672, 2007
|Evolutionary descent of prion genes from the ZIP family of metal ion transporters|
G Schmitt-Ulms, S Ehsani, JC Watts, D Westaway, H Wille
PloS one 4 (9), e7208, 2009
|Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones|
JC Watts, H Huo, Y Bai, S Ehsani, AH Won, T Shi, N Daude, A Lau, ...
PLoS pathogens 5 (10), e1000608, 2009
|Drug resistance confounding prion therapeutics|
DB Berry, D Lu, M Geva, JC Watts, S Bhardwaj, A Oehler, AR Renslo, ...
Proceedings of the National Academy of Sciences 110 (44), E4160-E4169, 2013
|α-Synuclein-based animal models of Parkinson's disease: challenges and opportunities in a new era|
NP Visanji, JM Brotchie, LV Kalia, JB Koprich, A Tandon, JC Watts, ...
Trends in neurosciences 39 (11), 750-762, 2016
|Bioluminescence imaging of Aβ deposition in bigenic mouse models of Alzheimer's disease|
JC Watts, K Giles, SK Grillo, A Lemus, SJ DeArmond, SB Prusiner
Proceedings of the National Academy of Sciences 108 (6), 2528-2533, 2011
|Evidence that bank vole PrP is a universal acceptor for prions|
JC Watts, K Giles, S Patel, A Oehler, SJ DeArmond, SB Prusiner
PLoS pathogens 10 (4), e1003990, 2014
|α-Synuclein strains target distinct brain regions and cell types|
A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, ...
Nature neuroscience 23 (1), 21-31, 2020
|Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B′ region|
B Drisaldi, J Coomaraswamy, P Mastrangelo, B Strome, J Yang, JC Watts, ...
Journal of Biological Chemistry 279 (53), 55443-55454, 2004
|Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease|
C Condello, T Lemmin, J Stöhr, M Nick, Y Wu, AM Maxwell, JC Watts, ...
Proceedings of the National Academy of Sciences 115 (4), E782-E791, 2018
|Spontaneous generation of anchorless prions in transgenic mice|
J Stöhr, JC Watts, G Legname, A Oehler, A Lemus, HOB Nguyen, ...
Proceedings of the National Academy of Sciences, 2011