|Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation|
DH Chui, H Tanahashi, K Ozawa, S Ikeda, F Checler, O Ueda, H Suzuki, ...
Nature medicine 5 (5), 560-564, 1999
|Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture|
W Araki, N Kitaguchi, Y Tokushima, K Ishii, H Aratake, S Shimohama, ...
Biochemical and biophysical research communications 181 (1), 265-271, 1991
|Reticulons RTN3 and RTN4‐B/C interact with BACE1 and inhibit its ability to produce amyloid β‐protein|
KS Murayama, F Kametani, S Saito, H Kume, H Akiyama, W Araki
European Journal of Neuroscience 24 (5), 1237-1244, 2006
|Endoplasmic reticulum chaperones inhibit the production of amyloid-β peptides|
T Hoshino, T Nakaya, W Araki, K Suzuki, T Suzuki, T Mizushima
Biochemical Journal 402 (3), 581-589, 2007
|Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth|
W Araki, RJ Wurtman
Proceedings of the National Academy of Sciences 94 (22), 11946-11950, 1997
|Homocysteic acid induces intraneuronal accumulation of neurotoxic Aβ42: implications for the pathogenesis of Alzheimer's disease|
T Hasegawa, W Ukai, DG Jo, X Xu, MP Mattson, M Nakagawa, W Araki, ...
Journal of neuroscience research 80 (6), 869-876, 2005
|Apoptotic neurons in Alzheimer's disease frequently show intracellular Aβ42 labeling|
DH Chui, E Dobo, T Makifuchi, H Akiyama, S Kawakatsu, A Petit, ...
Journal of Alzheimer's Disease 3 (2), 231-239, 2001
|Involvement of prostaglandin E2 in production of amyloid-β peptides both in vitro and in vivo|
T Hoshino, T Nakaya, T Homan, K Tanaka, Y Sugimoto, W Araki, M Narita, ...
Journal of Biological Chemistry 282 (45), 32676-32688, 2007
|Oxidative stress up‐regulates presenilin 1 in lipid rafts in neuronal cells|
A Oda, A Tamaoka, W Araki
Journal of neuroscience research 88 (5), 1137-1145, 2010
|Aberrant accumulation of phospholipase C-delta in Alzheimer brains.|
S Shimohama, Y Homma, T Suenaga, S Fujimoto, T Taniguchi, W Araki, ...
The American journal of pathology 139 (4), 737, 1991
|Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11‐splice site in the tau gene|
K Miyamoto, A Kowalska, M Hasegawa, T Tabira, K Takahashi, W Araki, ...
Annals of Neurology: Official Journal of the American Neurological …, 2001
|Glypican‐1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease|
N Watanabe, W Araki, DH Chui, T Makifuchi, Y Ihara, T Tabira
The FASEB journal 18 (9), 1013-1015, 2004
|Enhanced generation of intracellular Aβ42 amyloid peptide by mutation of presenilins PS1 and PS2|
K Takeda, W Araki, T Tabira
European Journal of Neuroscience 19 (2), 258-364, 2004
|Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation|
RKK Lee, W Araki, RJ Wurtman
Proceedings of the National Academy of Sciences 94 (10), 5422-5426, 1997
|Altered localization of amyloid precursor protein under endoplasmic reticulum stress|
T Kudo, M Okumura, K Imaizumi, W Araki, T Morihara, H Tanimukai, ...
Biochemical and biophysical research communications 344 (2), 525-530, 2006
|Prostaglandin E2 stimulates the production of amyloid-β peptides through internalization of the EP4 receptor|
T Hoshino, T Namba, M Takehara, T Nakaya, Y Sugimoto, W Araki, ...
Journal of Biological Chemistry 284 (27), 18493-18502, 2009
|Amino‐truncated amyloid β‐peptide (Aβ5‐40/42) produced from caspase‐cleaved amyloid precursor protein is deposited in Alzheimer’s disease brain|
K Takeda, W Araki, H Akiyama, T Tabira
The FASEB journal 18 (14), 1755-1757, 2004
|Pro‐apoptotic effect of presenilin 2 (PS2) overexpression is associated with down‐regulation of Bcl‐2 in cultured neurons|
W Araki, K Yuasa, S Takeda, K Takeda, K Shirotani, K Takahashi, ...
Journal of neurochemistry 79 (6), 1161-1168, 2001
|Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease|
S Shimohama, T Suenaga, W Araki, Y Yamaoaka, K Shimizu, J Kimura
Brain research 558 (1), 105-108, 1991
|How is membrane phospholipid biosynthesis controlled in neural tissues?|
W Araki, RJ Wurtman
Journal of neuroscience research 51 (6), 667-674, 1998