| Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells T Saito, T Chiba, K Yuki, Y Zen, M Oshima, S Koide, T Motoyama, ... PloS one 8 (7), e70010, 2013 | 100 | 2013 |
| Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma T Chiba, T Saito, K Yuki, Y Zen, S Koide, N Kanogawa, T Motoyama, ... International journal of cancer 136 (2), 289-298, 2015 | 94 | 2015 |
| Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and-independent manners T Chiba, E Suzuki, K Yuki, Y Zen, M Oshima, S Miyagi, A Saraya, S Koide, ... PloS one 9 (1), e84807, 2014 | 89 | 2014 |
| Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation R Kurimoto, S Iwasawa, T Ebata, T Ishiwata, I Sekine, Y Tada, K Tatsumi, ... International journal of oncology 48 (5), 1825-1836, 2016 | 85 | 2016 |
| Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes S Koide, M Oshima, K Takubo, S Yamazaki, E Nitta, A Saraya, K Aoyama, ... Blood, The Journal of the American Society of Hematology 128 (5), 638-649, 2016 | 73 | 2016 |
| Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition O Rizq, N Mimura, M Oshima, A Saraya, S Koide, Y Kato, K Aoyama, ... Clinical Cancer Research 23 (16), 4817-4830, 2017 | 63 | 2017 |
| Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche W Kuribayashi, M Oshima, N Itokawa, S Koide, Y Nakajima-Takagi, ... Journal of Experimental Medicine 218 (3), e20192283, 2020 | 56 | 2020 |
| Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia C Wang, G Sashida, A Saraya, R Ishiga, S Koide, M Oshima, K Isono, ... Blood, The Journal of the American Society of Hematology 123 (21), 3336-3343, 2014 | 46 | 2014 |
| Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies T Tanaka, Y Nakajima-Takagi, K Aoyama, S Tara, M Oshima, A Saraya, ... Journal of Experimental Medicine 214 (10), 2901-2913, 2017 | 45 | 2017 |
| Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma M Yokoyama, T Chiba, Y Zen, M Oshima, Y Kusakabe, Y Noguchi, K Yuki, ... Oncotarget 8 (13), 21315, 2017 | 45 | 2017 |
| Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome S Tara, Y Isshiki, Y Nakajima-Takagi, M Oshima, K Aoyama, T Tanaka, ... Blood, The Journal of the American Society of Hematology 132 (23), 2470-2483, 2018 | 44 | 2018 |
| Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells M Oshima, N Hasegawa, M Mochizuki-Kashio, T Muto, S Miyagi, S Koide, ... Experimental Hematology 44 (4), 282-296. e3, 2016 | 40 | 2016 |
| Ezh2 loss propagates hypermethylation at T cell differentiation–regulating genes to promote leukemic transformation C Wang, M Oshima, D Sato, H Matsui, S Kubota, K Aoyama, ... The Journal of Clinical Investigation 128 (9), 3872-3886, 2018 | 38 | 2018 |
| Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development Y Mishima, C Wang, S Miyagi, A Saraya, H Hosokawa, ... Nature communications 5 (1), 5872, 2014 | 37 | 2014 |
| Genetic and transcriptional landscape of plasma cells in POEMS syndrome Y Nagao, N Mimura, J Takeda, K Yoshida, Y Shiozawa, M Oshima, ... Leukemia 33 (7), 1723-1735, 2019 | 34 | 2019 |
| Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils Y Kimishima, T Misaka, T Yokokawa, K Wada, K Ueda, K Sugimoto, ... Nature Communications 12 (1), 6177, 2021 | 33 | 2021 |
| OGT regulates hematopoietic stem cell maintenance via PINK1-dependent mitophagy K Murakami, D Kurotaki, W Kawase, S Soma, Y Fukuchi, H Kunimoto, ... Cell reports 34 (1), 2021 | 31 | 2021 |
| Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells N Itokawa, M Oshima, S Koide, N Takayama, W Kuribayashi, ... Nature communications 13 (1), 2691, 2022 | 29 | 2022 |
| Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome N Hasegawa, M Oshima, G Sashida, H Matsui, S Koide, A Saraya, ... Leukemia 31 (4), 861-871, 2017 | 28 | 2017 |
| UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes Y Sera, Y Nakata, T Ueda, N Yamasaki, S Koide, H Kobayashi, K Ikeda, ... Blood, The Journal of the American Society of Hematology 137 (7), 908-922, 2021 | 26 | 2021 |
