Philip C. Wong
Philip C. Wong
Professor Pathology
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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
PC Wong, CA Pardo, DR Borchelt, MK Lee, NG Copeland, NA Jenkins, ...
Neuron 14 (6), 1105-1116, 1995
Amyloid precursor protein processing and Alzheimer's disease
RJ O'brien, PC Wong
Annual review of neuroscience 34, 185-204, 2011
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
H Cai, Y Wang, D McCarthy, H Wen, DR Borchelt, DL Price, PC Wong
Nature neuroscience 4 (3), 233-234, 2001
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
PC Wong, H Zheng, H Chen, MW Becher, DJS Sirinathsinghji, ...
Nature 387 (6630), 288-292, 1997
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
LB Yang, K Lindholm, R Yan, M Citron, W Xia, XL Yang, T Beach, L Sue, ...
Nature medicine 9 (1), 3-4, 2003
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity
DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, RH Brown, ...
Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994
Bace1 modulates myelination in the central and peripheral nervous system
X Hu, CW Hicks, W He, P Wong, WB Macklin, BD Trapp, R Yan
Nature neuroscience 9 (12), 1520-1525, 2006
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
BD Freibaum, Y Lu, R Lopez-Gonzalez, NC Kim, S Almeida, KH Lee, ...
Nature 525 (7567), 129-133, 2015
An overview of APP processing enzymes and products
VW Chow, MP Mattson, PC Wong, M Gleichmann
Neuromolecular medicine 12 (1), 1-12, 2010
The β-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential
R Vassar, DM Kovacs, R Yan, PC Wong
Journal of neuroscience 29 (41), 12787-12794, 2009
BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
FM Laird, H Cai, AV Savonenko, MH Farah, K He, T Melnikova, H Wen, ...
Journal of Neuroscience 25 (50), 11693-11709, 2005
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
J Liu, C Lillo, PA Jonsson, CV Velde, CM Ward, TM Miller, ...
Neuron 43 (1), 5-17, 2004
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients
R Li, K Lindholm, LB Yang, X Yue, M Citron, R Yan, T Beach, L Sue, ...
Proceedings of the National Academy of Sciences 101 (10), 3632-3637, 2004
Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes
KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li, N Nukina, PC Wong, H Xu, ...
Journal of Biological Chemistry 279 (43), 44945-44954, 2004
Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues
M Watanabe, M Dykes-Hoberg, VC Culotta, DL Price, PC Wong, ...
Neurobiology of disease 8 (6), 933-941, 2001
Effects of PS1 deficiency on membrane protein trafficking in neurons
S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita, T Iwatsubo, X Qian, ...
Neuron 21 (5), 1213-1221, 1998
Neurofilaments are obligate heteropolymers in vivo
MK Lee, Z Xu, PC Wong, DW Cleveland
Journal of Cell Biology 122 (6), 1337-1350, 1993
Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.
S Rabizadeh, EB Gralla, DR Borchelt, R Gwinn, JS Valentine, S Sisodia, ...
Proceedings of the National Academy of Sciences 92 (7), 3024-3028, 1995
Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine …
LI Bruijn, MF Beal, MW Becher, JB Schulz, PC Wong, DL Price, ...
Proceedings of the National Academy of Sciences 94 (14), 7606-7611, 1997
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase
PC Wong, D Waggoner, JR Subramaniam, L Tessarollo, TB Bartnikas, ...
Proceedings of the National Academy of Sciences 97 (6), 2886-2891, 2000
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