Mitochondrial dysfunction induces senescence with a distinct secretory phenotype CD Wiley, MC Velarde, P Lecot, SU Liu, EA Sarnoski, A Freund, ... Cell metabolism 23 (2), 303-314, 2016 | 976 | 2016 |
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging DV Ziegler, CD Wiley, MC Velarde Aging cell 14 (1), 1-7, 2015 | 376 | 2015 |
From ancient pathways to aging cells—connecting metabolism and cellular senescence CD Wiley, J Campisi Cell metabolism 23 (6), 1013-1021, 2016 | 359 | 2016 |
The metabolic roots of senescence: mechanisms and opportunities for intervention CD Wiley, J Campisi Nature Metabolism 3 (10), 1290-1301, 2021 | 266 | 2021 |
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice AA Shahmirzadi, D Edgar, CY Liao, YM Hsu, M Lucanic, AA Shahmirzadi, ... Cell metabolism 32 (3), 447-456. e6, 2020 | 237 | 2020 |
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages AJ Covarrubias, A Kale, R Perrone, JA Lopez-Dominguez, AO Pisco, ... Nature metabolism 2 (11), 1265-1283, 2020 | 233 | 2020 |
Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence CD Wiley, JM Flynn, C Morrissey, R Lebofsky, J Shuga, X Dong, ... Aging cell 16 (5), 1043-1050, 2017 | 219 | 2017 |
Context-dependent effects of cellular senescence in cancer development P Lecot, F Alimirah, PY Desprez, J Campisi, C Wiley British journal of cancer 114 (11), 1180-1184, 2016 | 184 | 2016 |
Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration P Patil, Q Dong, D Wang, J Chang, C Wiley, M Demaria, J Lee, J Kang, ... Aging cell 18 (3), e12927, 2019 | 139 | 2019 |
Melanism in Peromyscus Is Caused by Independent Mutations in Agouti EP Kingsley, M Manceau, CD Wiley, HE Hoekstra PloS one 4 (7), e6435, 2009 | 135 | 2009 |
Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells KM Perrott, CD Wiley, PY Desprez, J Campisi Geroscience 39, 161-173, 2017 | 126 | 2017 |
Disease drivers of aging RJ Hodes, F Sierra, SN Austad, E Epel, GN Neigh, KM Erlandson, ... Annals of the New York Academy of Sciences 1386 (1), 45-68, 2016 | 124 | 2016 |
SILAC analysis reveals increased secretion of hemostasis-related factors by senescent cells CD Wiley, S Liu, C Limbad, AM Zawadzka, J Beck, M Demaria, R Artwood, ... Cell reports 28 (13), 3329-3337. e5, 2019 | 117 | 2019 |
Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype CD Wiley, N Schaum, F Alimirah, JA Lopez-Dominguez, AV Orjalo, ... Scientific reports 8 (1), 2410, 2018 | 111 | 2018 |
Impaired placental trophoblast lineage differentiation in Alkbh1−/− mice Z Pan, S Sikandar, M Witherspoon, D Dizon, T Nguyen, K Benirschke, ... Developmental dynamics 237 (2), 316-327, 2008 | 96 | 2008 |
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis CD Wiley, R Sharma, SS Davis, JA Lopez-Dominguez, KP Mitchell, ... Cell metabolism 33 (6), 1124-1136. e5, 2021 | 90 | 2021 |
Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis CD Wiley, AN Brumwell, SS Davis, JR Jackson, A Valdovinos, C Calhoun, ... JCI insight 4 (24), 2019 | 85 | 2019 |
Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/42MAPK signaling F Alimirah, T Pulido, A Valdovinos, S Alptekin, E Chang, E Jones, DA Diaz, ... Cancer research 80 (17), 3606-3619, 2020 | 81 | 2020 |
Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin DE Kim, MET Dollé, WP Vermeij, A Gyenis, K Vogel, JHJ Hoeijmakers, ... Aging Cell 19 (3), e13072, 2020 | 50 | 2020 |
Peromyscus (deer mice) as developmental models PB Vrana, KR Shorter, G Szalai, MR Felder, JP Crossland, M Veres, ... Wiley Interdisciplinary Reviews: Developmental Biology 3 (3), 211-230, 2014 | 27 | 2014 |