T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility OY Borbulevych, KH Piepenbrink, BE Gloor, DR Scott, RF Sommese, ... Immunity 31 (6), 885-896, 2009 | 230 | 2009 |
Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes KM Armstrong, KH Piepenbrink, BM Baker Biochemical Journal 415 (2), 183-196, 2008 | 173 | 2008 |
A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice Z Yang, D Schmidt, W Liu, S Li, L Shi, J Sheng, K Chen, H Yu, ... The Journal of infectious diseases 210 (6), 964-972, 2014 | 109 | 2014 |
Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics OY Borbulevych, KH Piepenbrink, BM Baker The Journal of Immunology 186 (5), 2950-2958, 2011 | 97 | 2011 |
Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism DR Scott, OY Borbulevych, KH Piepenbrink, SA Corcelli, BM Baker Journal of molecular biology 414 (3), 385-400, 2011 | 89 | 2011 |
Type IV pili promote early biofilm formation by Clostridium difficile GA Maldarelli, KH Piepenbrink, AJ Scott, JA Freiberg, Y Song, ... FEMS Pathogens and Disease 74 (6), ftw061, 2016 | 84 | 2016 |
Motility and adhesion through type IV pili in Gram-positive bacteria KH Piepenbrink, EJ Sundberg Biochemical Society Transactions 44 (6), 1659-1666, 2016 | 80 | 2016 |
Structural diversity in the type IV pili of multidrug-resistant Acinetobacter KH Piepenbrink, E Lillehoj, CM Harding, JW Labonte, X Zuo, CA Rapp, ... Journal of Biological Chemistry 291 (44), 22924-22935, 2016 | 78 | 2016 |
Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains DH Aggen, AS Chervin, TM Schmitt, B Engels, JD Stone, SA Richman, ... Gene therapy 19 (4), 365-374, 2012 | 77 | 2012 |
Structure-based design of hepatitis C virus vaccines that elicit neutralizing antibody responses to a conserved epitope BG Pierce, EN Boucher, KH Piepenbrink, M Ejemel, CA Rapp, ... Journal of virology 91 (20), 10.1128/jvi. 01032-17, 2017 | 64 | 2017 |
The basis for limited specificity and MHC restriction in a T cell receptor interface KH Piepenbrink, SJ Blevins, DR Scott, BM Baker Nature communications 4 (1), 1948, 2013 | 63 | 2013 |
Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors DH Aggen, AS Chervin, FK Insaidoo, KH Piepenbrink, BM Baker, ... Protein Engineering, Design & Selection 24 (4), 361-372, 2011 | 63 | 2011 |
Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain W Piao, LW Ru, KH Piepenbrink, EJ Sundberg, SN Vogel, VY Toshchakov Proceedings of the National Academy of Sciences 110 (47), 19036-19041, 2013 | 60 | 2013 |
The structure of PilA from Acinetobacter baumannii AB5075 suggests a mechanism for functional specialization in Acinetobacter type IV pili LA Ronish, E Lillehoj, JK Fields, EJ Sundberg, KH Piepenbrink Journal of Biological Chemistry 294 (1), 218-230, 2019 | 58 | 2019 |
Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of Clostridium difficile KH Piepenbrink, GA Maldarelli, CFM De La Peña, TC Dingle, GL Mulvey, ... Structure 23 (2), 385-396, 2015 | 57 | 2015 |
DNA uptake by type IV filaments KH Piepenbrink Frontiers in Molecular Biosciences 6, 1, 2019 | 53 | 2019 |
How an alloreactive T-cell receptor achieves peptide and MHC specificity Y Wang, NK Singh, TT Spear, LM Hellman, KH Piepenbrink, ... Proceedings of the National Academy of Sciences 114 (24), E4792-E4801, 2017 | 52 | 2017 |
Structure of Clostridium difficile PilJ exhibits unprecedented divergence from known type IV pilins KH Piepenbrink, GA Maldarelli, CFM De La Peña, GL Mulvey, GA Snyder, ... Journal of Biological Chemistry 289 (7), 4334-4345, 2014 | 49 | 2014 |
Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner KH Piepenbrink, OY Borbulevych, RF Sommese, J Clemens, ... Biochemical Journal 423 (3), 353-361, 2009 | 42 | 2009 |
The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo SW Hyun, A Liu, Z Liu, AS Cross, AC Verceles, S Magesh, Y Kommagalla, ... Glycobiology 26 (8), 834-849, 2016 | 40 | 2016 |