AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ... Oncogene 31 (15), 1949-1962, 2012 | 276 | 2012 |
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ... Science signaling 4 (188), ra56-ra56, 2011 | 168 | 2011 |
The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation LM Ooms, CG Fedele, MV Astle, I Ivetac, V Cheung, RB Pearson, ... Molecular biology of the cell 17 (2), 607-622, 2006 | 87 | 2006 |
The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2 JM Dyson, AM Kong, F Wiradjaja, MV Astle, R Gurung, CA Mitchell The international journal of biochemistry & cell biology 37 (11), 2260-2265, 2005 | 76 | 2005 |
The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors? MV Astle, KA Horan, LM Ooms, CA Mitchell Biochemical Society Symposia 74, 161-181, 2007 | 70 | 2007 |
The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence M Wall, G Poortinga, KL Stanley, RK Lindemann, M Bots, CJ Chan, ... Cancer discovery 3 (1), 82-95, 2013 | 68 | 2013 |
Regulation of phosphoinositide signaling by the inositol polyphosphate 5‐phosphatases MV Astle, G Seaton, EM Davies, CG Fedele, P Rahman, L Arsala, ... Iubmb Life 58 (8), 451-456, 2006 | 62 | 2006 |
P-Rex1–a multidomain protein that regulates neurite differentiation JAE Waters, MV Astle, LM Ooms, D Balamatsias, R Gurung, CA Mitchell Journal of cell science 121 (17), 2892-2903, 2008 | 53 | 2008 |
Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)· collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation MV Astle, LM Ooms, AR Cole, LC Binge, JM Dyson, MJ Layton, S Petratos, ... Journal of Biological Chemistry 286 (26), 23407-23418, 2011 | 24 | 2011 |
AKT is a critical regulator of rRNA synthesis and cooperates with c-MYC to control ribosome biogenesis in cancer JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ... Science Signaling 4 (188), ra56, 2011 | 1 | 2011 |
The 5-phosphatase PIPP binds CRMP proteins and is a novel regulator of neuron differentiation MV Astle Monash University, 2008 | 1 | 2008 |
Analyze p53 degradation by 35S p53 Pulse Chase Analysis M Astle, R Pearson, K Hannan Bio-protocol 2 (21), e283-e283, 2012 | | 2012 |
594 A novel form of cellular senescence induced by hyper-activation of the PI3K/Akt pathway MV Astle, RD Hannan, RB Pearson ejc supplements 5 (8), 151, 2010 | | 2010 |
SHOWCASE ON RESEARCH M Astle, G Seaton, M Davies, C Fedele, P Rahman, L Arsala, C Mitchell | | |