| Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice JA Carrero, DP McCarthy, ST Ferris, X Wan, H Hu, BH Zinselmeyer, ... Proceedings of the National Academy of Sciences 114 (48), E10418-E10427, 2017 | 140 | 2017 |
| Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells AN Vomund, BH Zinselmeyer, J Hughes, B Calderon, C Valderrama, ... Proceedings of the National Academy of Sciences 112 (40), E5496-E5502, 2015 | 109 | 2015 |
| FoxP3+ RORγt+ T helper intermediates display suppressive function against autoimmune diabetes DM Tartar, AM VanMorlan, X Wan, FB Guloglu, R Jain, CL Haymaker, ... The Journal of Immunology 184 (7), 3377-3385, 2010 | 104 | 2010 |
| The islet-resident macrophage is in an inflammatory state and senses microbial products in blood ST Ferris, PN Zakharov, X Wan, B Calderon, MN Artyomov, ER Unanue, ... Journal of Experimental Medicine 214 (8), 2369-2385, 2017 | 100 | 2017 |
| Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides X Wan, BH Zinselmeyer, PN Zakharov, AN Vomund, R Taniguchi, ... Nature 560 (7716), 107-111, 2018 | 98 | 2018 |
| Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes PN Zakharov, H Hu, X Wan, ER Unanue Journal of Experimental Medicine 217 (6), 2020 | 97 | 2020 |
| The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides X Wan, AN Vomund, OJ Peterson, AV Chervonsky, CF Lichti, ER Unanue Nature immunology 21 (4), 455-463, 2020 | 67 | 2020 |
| Transient depletion of CD4+ CD25+ regulatory T cells results in multiple autoimmune diseases in wild‐type and B‐cell‐deficient NOD mice JS Ellis, X Wan, H Braley‐Mullen Immunology 139 (2), 179-186, 2013 | 60 | 2013 |
| Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset L Gioia, M Holt, A Costanzo, S Sharma, B Abe, L Kain, M Nakayama, ... Science immunology 4 (38), eaaw6329, 2019 | 46 | 2019 |
| Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites X Wan, JW Thomas, ER Unanue Journal of Experimental Medicine 213 (6), 967-978, 2016 | 46 | 2016 |
| IL‐13 R α1 is a surface marker for M 2 macrophages influencing their differentiation and function M Dhakal, JC Hardaway, FB Guloglu, MM Miller, CM Hoeman, ... European journal of immunology 44 (3), 842-855, 2014 | 33 | 2014 |
| Mechanisms underlying antigen-specific tolerance of stable and convertible Th17 cells during suppression of autoimmune diabetes X Wan, FB Guloglu, AM VanMorlan, LM Rowland, R Jain, CL Haymaker, ... Diabetes 61 (8), 2054-2065, 2012 | 22 | 2012 |
| Recovery from overt type 1 diabetes ensues when immune tolerance and β-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets X Wan, FB Guloglu, AM VanMorlan, LM Rowland, S Zaghouani, ... Diabetes 62 (8), 2879-2889, 2013 | 21 | 2013 |
| Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn CM Hoeman, M Dhakal, AA Zaghouani, JA Cascio, X Wan, MT Khairallah, ... The Journal of Immunology 190 (12), 6155-6163, 2013 | 21 | 2013 |
| The immunoreactive platform of the pancreatic islets influences the development of autoreactivity ER Unanue, X Wan Diabetes 68 (8), 1544-1551, 2019 | 19 | 2019 |
| Neutrophils induce the maturation of immature dendritic cells: a regulatory role of neutrophils in adaptive immune responses W Xiaoxiao, Y Sibiao, X Xiaopeng, Z Ping, C Gang Immunological Investigations 36 (3), 337-350, 2007 | 17 | 2007 |
| Bone Marrow-Derived IL-13Rα1–Positive Thymic Progenitors Are Restricted to the Myeloid Lineage CL Haymaker, FB Guloglu, JA Cascio, JC Hardaway, M Dhakal, X Wan, ... The Journal of Immunology 188 (7), 3208-3216, 2012 | 16 | 2012 |
| Unique features in the presentation of insulin epitopes in autoimmune diabetes: an update X Wan, ER Unanue Current opinion in immunology 46, 30-37, 2017 | 15 | 2017 |
| Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets AN Vomund, CF Lichti, OJ Peterson, AM Arbelaez, X Wan, ER Unanue Journal of Experimental Medicine 218 (6), e20202530, 2021 | 12 | 2021 |
| Antigen-specific therapy against type 1 diabetes: mechanisms and perspectives X Wan, H Zaghouani Immunotherapy 6 (2), 155-164, 2014 | 12 | 2014 |
