Jochen Walter
Jochen Walter
Professor Molekulare Neurologie, Universität Bonn
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
M Okochi, J Walter, A Koyama, S Nakajo, M Baba, T Iwatsubo, L Meijer, ...
Journal of Biological Chemistry 275 (1), 390-397, 2000
Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent
L Meijer, AMWH Thunnissen, AW White, M Garnier, M Nikolic, LH Tsai, ...
Chemistry & biology 7 (1), 51-63, 2000
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
T Tomita, K Maruyama, TC Saido, H Kume, K Shinozaki, S Tokuhiro, ...
Proceedings of the National Academy of Sciences 94 (5), 2025-2030, 1997
Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ
M Sastre, I Dewachter, S Rossner, N Bogdanovic, E Rosen, P Borghgraef, ...
Proceedings of the National Academy of Sciences 103 (2), 443-448, 2006
Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine
MT Heneka, F Nadrigny, T Regen, A Martinez-Hernandez, ...
Proceedings of the National Academy of Sciences 107 (13), 6058-6063, 2010
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
C Venegas, S Kumar, BS Franklin, T Dierkes, R Brinkschulte, D Tejera, ...
Nature 552 (7685), 355-361, 2017
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide
S Lammich, M Okochi, M Takeda, C Kaether, A Capell, AK Zimmer, ...
Journal of Biological Chemistry 277 (47), 44754-44759, 2002
Phosphorylation regulates intracellular trafficking of β-secretase
J Walter, R Fluhrer, B Hartung, M Willem, C Kaether, A Capell, S Lammich, ...
Journal of Biological Chemistry 276 (18), 14634-14641, 2001
Maturation and pro-peptide cleavage of β-secretase
A Capell, H Steiner, M Willem, H Kaiser, C Meyer, J Walter, S Lammich, ...
Journal of Biological Chemistry 275 (40), 30849-30854, 2000
Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP [V717I] transgenic mice
MT Heneka, M Sastre, L Dumitrescu-Ozimek, I Dewachter, J Walter, ...
Journal of neuroinflammation 2 (1), 1-12, 2005
TLR2 is a primary receptor for Alzheimer’s amyloid β peptide to trigger neuroinflammatory activation
S Liu, Y Liu, W Hao, L Wolf, AJ Kiliaan, B Penke, CE Rübe, J Walter, ...
The Journal of Immunology 188 (3), 1098-1107, 2012
The Alzheimer’s disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
J Walter, A Capell, J Grünberg, B Pesold, A Schindzielorz, R Prior, ...
Molecular medicine 2 (6), 673-691, 1996
Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation
MP Kummer, M Hermes, A Delekarte, T Hammerschmidt, S Kumar, ...
Neuron 71 (5), 833-844, 2011
The cell biology of Alzheimer's disease: uncovering the secrets of secretases
J Walter, C Kaether, H Steiner, C Haass
Current opinion in neurobiology 11 (5), 585-590, 2001
Interactions between APP secretases and inflammatory mediators
M Sastre, J Walter, SM Gentleman
Journal of neuroinflammation 5 (1), 1-11, 2008
Extracellular phosphorylation of the amyloid β‐peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease
S Kumar, N Rezaei‐Ghaleh, D Terwel, DR Thal, M Richard, M Hoch, ...
The EMBO journal 30 (11), 2255-2265, 2011
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage
P Wunderlich, K Glebov, N Kemmerling, NT Tien, H Neumann, J Walter
Journal of Biological Chemistry 288 (46), 33027-33036, 2013
Phosphorylation of amyloid beta (Aβ) peptides–A trigger for formation of toxic aggregates in Alzheimer's disease
S Kumar, J Walter
Aging (Albany NY) 3 (8), 803, 2011
Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
IY Tamboli, E Barth, L Christian, M Siepmann, S Kumar, S Singh, ...
Journal of biological chemistry 285 (48), 37405-37414, 2010
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