| Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain Y Anraku, H Kuwahara, Y Fukusato, A Mizoguchi, T Ishii, K Nitta, ... Nature communications 8 (1), 1001, 2017 | 233 | 2017 |
| In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle S Uchida, K Itaka, H Uchida, K Hayakawa, T Ogata, T Ishii, S Fukushima, ... PloS one 8 (2), e56220, 2013 | 144 | 2013 |
| Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety S Uchida, H Kinoh, T Ishii, A Matsui, TA Tockary, KM Takeda, H Uchida, ... Biomaterials 82, 221-228, 2016 | 141 | 2016 |
| Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors Z Ge, Q Chen, K Osada, X Liu, TA Tockary, S Uchida, A Dirisala, T Ishii, ... Biomaterials 35 (10), 3416-3426, 2014 | 135 | 2014 |
| Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response. H Takemoto, K Miyata, S Hattori, T Ishii, T Suma, S Uchida, N Nishiyama, ... Angewandte Chemie 125 (24), 2013 | 127 | 2013 |
| Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment H Aini, K Itaka, A Fujisawa, H Uchida, S Uchida, S Fukushima, K Kataoka, ... Scientific reports 6 (1), 18743, 2016 | 118 | 2016 |
| Tethered PEG crowdedness determining shape and blood circulation profile of polyplex micelle gene carriers TA Tockary, K Osada, Q Chen, K Machitani, A Dirisala, S Uchida, ... Macromolecules 46 (16), 6585-6592, 2013 | 117 | 2013 |
| Nanomedicine-based approaches for mRNA delivery S Uchida, F Perche, C Pichon, H Cabral Molecular pharmaceutics 17 (10), 3654-3684, 2020 | 108 | 2020 |
| Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases A Matsui, S Uchida, T Ishii, K Itaka, K Kataoka Scientific reports 5 (1), 15810, 2015 | 96 | 2015 |
| Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in … CY Lin, F Perche, M Ikegami, S Uchida, K Kataoka, K Itaka Journal of Controlled Release 235, 268-275, 2016 | 92 | 2016 |
| Screening of mRNA chemical modification to maximize protein expression with reduced immunogenicity S Uchida, K Kataoka, K Itaka Pharmaceutics 7 (3), 137-151, 2015 | 90 | 2015 |
| Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA S Uchida, K Kataoka Journal of Biomedical Materials Research Part A 107 (5), 978-990, 2019 | 82 | 2019 |
| Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side … T Suma, K Miyata, T Ishii, S Uchida, H Uchida, K Itaka, N Nishiyama, ... Biomaterials 33 (9), 2770-2779, 2012 | 82 | 2012 |
| PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses S Uchida, K Itaka, Q Chen, K Osada, T Ishii, MA Shibata, M Harada-Shiba, ... Molecular Therapy 20 (6), 1196-1203, 2012 | 79 | 2012 |
| Polyplex micelles with phenylboronate/gluconamide cross-linking in the core exerting promoted gene transfection through spatiotemporal responsivity to intracellular pH and ATP … N Yoshinaga, T Ishii, M Naito, T Endo, S Uchida, H Cabral, K Osada, ... Journal of the American Chemical Society 139 (51), 18567-18575, 2017 | 78 | 2017 |
| Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids S Uchida, K Hayakawa, T Ogata, S Tanaka, K Kataoka, K Itaka Biomaterials 109, 1-11, 2016 | 69 | 2016 |
| Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors A Dirisala, K Osada, Q Chen, TA Tockary, K Machitani, S Osawa, X Liu, ... Biomaterials 35 (20), 5359-5368, 2014 | 69 | 2014 |
| Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors Q Chen, K Osada, T Ishii, M Oba, S Uchida, TA Tockary, T Endo, Z Ge, ... Biomaterials 33 (18), 4722-4730, 2012 | 68 | 2012 |
| Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain S Abbasi, S Uchida, K Toh, TA Tockary, A Dirisala, K Hayashi, ... Journal of Controlled Release 332, 260-268, 2021 | 63 | 2021 |
| Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability A Dirisala, S Uchida, TA Tockary, N Yoshinaga, J Li, S Osawa, L Gorantla, ... Journal of Drug Targeting 27 (5-6), 670-680, 2019 | 63 | 2019 |
