| Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli Y Katsuyama, N Funa, I Miyahisa, S Horinouchi Chemistry & biology 14 (6), 613-621, 2007 | 273 | 2007 |
| Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster I Miyahisa, M Kaneko, N Funa, H Kawasaki, H Kojima, Y Ohnishi, ... Applied microbiology and biotechnology 68, 498-504, 2005 | 229 | 2005 |
| Combinatorial biosynthesis of flavones and flavonols in Escherichia coli I Miyahisa, N Funa, Y Ohnishi, S Martens, T Moriguchi, S Horinouchi Applied microbiology and biotechnology 71, 53-58, 2006 | 199 | 2006 |
| Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins Y Tanaka, K Aikawa, G Nishida, M Homma, S Sogabe, S Igaki, Y Hayano, ... Journal of medicinal chemistry 56 (23), 9635-9645, 2013 | 128 | 2013 |
| One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells Y Katsuyama, I Miyahisa, N Funa, S Horinouchi Applied microbiology and biotechnology 73, 1143-1149, 2007 | 88 | 2007 |
| Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact /KI) by Means of an Endpoint Competition Assay Ikuo Miyahisa, Tomoya Sameshima, Mark S Hixon Angewandte Chemie International Edition 54 (47), 14099–14102, 2015 | 55* | 2015 |
| A Single Target Is Sufficient To Account for the Biological Effects of the A-Factor Receptor Protein of Streptomyces griseus J Kato, I Miyahisa, M Mashiko, Y Ohnishi, S Horinouchi Journal of bacteriology 186 (7), 2206-2211, 2004 | 55 | 2004 |
| A novel selective inhibitor of delta-5 desaturase lowers insulin resistance and reduces body weight in diet-induced obese C57BL/6J mice H Yashiro, S Takagahara, YO Tamura, I Miyahisa, J Matsui, H Suzuki, ... PLoS One 11 (11), e0166198, 2016 | 40 | 2016 |
| Discovery of novel and potent stearoyl coenzyme a desaturase 1 (SCD1) inhibitors as anticancer agents K Imamura, N Tomita, Y Kawakita, Y Ito, K Ono, N Nii, T Miyazaki, ... Bioorganic & medicinal chemistry 25 (14), 3768-3779, 2017 | 39 | 2017 |
| Discovery of an irreversible and cell-active BCL6 inhibitor selectively targeting Cys53 located at the protein–protein interaction interface T Sameshima, T Yamamoto, O Sano, S Sogabe, S Igaki, K Sakamoto, ... Biochemistry 57 (8), 1369-1379, 2018 | 27 | 2018 |
| In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor S Nishizawa, H Sumi, Y Satoh, Y Yamamoto, S Kitazawa, K Honda, ... European journal of pharmacology 807, 21-31, 2017 | 24 | 2017 |
| Discovery of 3, 5-diphenyl-4-methyl-1, 3-oxazolidin-2-ones as novel, potent, and orally available Δ-5 desaturase (D5D) inhibitors J Fujimoto, R Okamoto, N Noguchi, R Hara, S Masada, T Kawamoto, ... Journal of Medicinal Chemistry 60 (21), 8963-8981, 2017 | 21 | 2017 |
| Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application Y Hirozane, M Toyofuku, T Yogo, Y Tanaka, T Sameshima, I Miyahisa, ... Bioorganic & medicinal chemistry letters 29 (21), 126641, 2019 | 17 | 2019 |
| T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time I Miyahisa, H Suzuki, A Mizukami, Y Tanaka, M Ono, MS Hixon, J Matsui ACS Medicinal Chemistry Letters 7 (9), 868-872, 2016 | 17 | 2016 |
| Small-scale panel comprising diverse gene family targets to evaluate compound promiscuity T Sameshima, T Yukawa, Y Hirozane, M Yoshikawa, T Katoh, H Hara, ... Chemical Research in Toxicology 33 (1), 154-161, 2019 | 13 | 2019 |
| High-throughput quantitative intrinsic thiol reactivity evaluation using a fluorescence-based competitive endpoint assay T Sameshima, I Miyahisa, S Yamasaki, M Gotou, T Kobayashi, ... SLAS DISCOVERY: Advancing Life Sciences R&D 22 (9), 1168-1174, 2017 | 13 | 2017 |
| Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792 M Sasaki, I Miyahisa, S Itono, H Yashiro, H Hiyoshi, K Tsuchimori, ... Pharmacology research & perspectives 7 (5), e00517, 2019 | 12 | 2019 |
| Universal and quantitative method to evaluate inhibitor potency for cysteinome proteins using a nonspecific activity-based protein profiling probe T Sameshima, Y Tanaka, I Miyahisa Biochemistry 56 (23), 2921-2927, 2017 | 5 | 2017 |
| A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay T Sameshima, I Miyahisa, M Homma, K Aikawa, MS Hixon, J Matsui Bioorganic & Medicinal Chemistry Letters, 2014 | 2 | 2014 |
| Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R, 10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium … SWJ Shields, PH Buist, JM Manthorpe SynOpen 2 (02), 0168-0175, 2018 | 1 | 2018 |
Yasuo OhnishiThe University of Tokyo確認したメール アドレス: mail.ecc.u-tokyo.ac.jp
