Masaya Baba M.D., Ph.D.
Masaya Baba M.D., Ph.D.
Associate Professor, International Research Center for Medical Sciences (IRCMS), Kumamoto University
Verified email at
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Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
M Baba, SB Hong, N Sharma, MB Warren, ML Nickerson, A Iwamatsu, ...
Proceedings of the National Academy of Sciences 103 (42), 15552-15557, 2006
VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma
M Yao, M Yoshida, T Kishida, N Nakaigawa, M Baba, K Kobayashi, ...
Journal of the National Cancer Institute 94 (20), 1569-1575, 2002
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys
M Baba, M Furihata, SB Hong, L Tessarollo, DC Haines, E Southon, ...
Journal of the National Cancer Institute 100 (2), 140-154, 2008
Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters
K Kondo, M Yao, M Yoshida, T Kishida, T Shuin, T Miura, M Moriyama, ...
Genes, Chromosomes and Cancer 34 (1), 58-68, 2002
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
Y Hasumi, M Baba, R Ajima, H Hasumi, VA Valera, ME Klein, DC Haines, ...
Proceedings of the National Academy of Sciences 106 (44), 18722-18727, 2009
The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
H Okuda, K Saitoh, S Hirai, K Iwai, Y Takaki, M Baba, N Minato, S Ohno, ...
Journal of Biological Chemistry 276 (47), 43611-43617, 2001
Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling
Y Kato, CA Lambert, AC Colige, P Mineur, A NoŽl, F Frankenne, ...
Journal of Biological Chemistry 280 (12), 10938-10944, 2005
Identification and characterization of a novel folliculin-interacting protein FNIP2
H Hasumi, M Baba, SB Hong, Y Hasumi, Y Huang, M Yao, VA Valera, ...
Gene 415 (1-2), 60-67, 2008
Gene expression analysis of renal carcinoma: adipose differentiation‐related protein as a potential diagnostic and prognostic biomarker for clear‐cell renal carcinoma
M Yao, H Tabuchi, Y Nagashima, M Baba, N Nakaigawa, H Ishiguro, ...
The Journal of Pathology: A Journal of the Pathological Society of Great†…, 2005
Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization
SB Hong, HB Oh, VA Valera, M Baba, LS Schmidt, WM Linehan
PloS one 5 (12), e15793, 2010
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.
Ming Yan, …tienne Audet-Walsh, Sanaz Manteghi, Catherine Rosa Dufour ...
Genes & Development 30 (9), 1034-1046, 2016
Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma
N Nakaigawa, M Yao, M Baba, S Kato, T Kishida, K Hattori, Y Nagashima, ...
Cancer research 66 (7), 3699-3705, 2006
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene
W Ma, L Tessarollo, SB Hong, M Baba, E Southon, TC Back, S Spence, ...
Cancer research 63 (17), 5320-5328, 2003
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor
M Baba, S Hirai, H Yamada-Okabe, K Hamada, H Tabuchi, K Kobayashi, ...
Oncogene 22 (18), 2728-2738, 2003
PTEN/MMAC1/TEP1 mutations in human primary renal‐cell carcinomas and renal carcinoma cell lines
K Kondo, M Yao, K Kobayashi, S Ota, M Yoshida, S Kaneko, M Baba, ...
International journal of cancer 91 (2), 219-224, 2001
Direct interaction of the β-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes
H Okuda, S Hirai, Y Takaki, M Kamada, M Baba, N Sakai, T Kishida, ...
Biochemical and biophysical research communications 263 (2), 491-497, 1999
Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling
SB Hong, HB Oh, VA Valera, J Stull, DT Ngo, M Baba, MJ Merino, ...
Molecular cancer 9, 1-13, 2010
Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn
H Hasumi, M Baba, Y Hasumi, M Lang, Y Huang, HBF Oh, M Matsuo, ...
Proceedings of the National Academy of Sciences 112 (13), E1624-E1631, 2015
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo
S Hirai, A Kawaguchi, R Hirasawa, M Baba, T Ohnishi, S Ohno
Oxford University Press for The Company of Biologists Limited 129 (19), 4483†…, 2002
Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN
H Hasumi, M Baba, Y Hasumi, Y Huang, H Oh, RM Hughes, ME Klein, ...
Journal of the National Cancer Institute 104 (22), 1750-1764, 2012
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