Peter Sheffield
Peter Sheffield
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Overcoming expression and purification problems of RhoGDI using a family of “parallel” expression vectors
P Sheffield, S Garrard, Z Derewenda
Protein expression and purification 15 (1), 34-39, 1999
A HUPO test sample study reveals common problems in mass spectrometry–based proteomics
AW Bell, EW Deutsch, CE Au, RE Kearney, R Beavis, S Sechi, T Nilsson, ...
Nature methods 6 (6), 423-430, 2009
Borg proteins control septin organization and are negatively regulated by Cdc42
G Joberty, RR Perlungher, PJ Sheffield, M Kinoshita, M Noda, T Haystead, ...
Nature cell biology 3 (10), 861-866, 2001
Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments
PJ Sheffield, CJ Oliver, BE Kremer, S Sheng, Z Shao, IG Macara
Journal of Biological Chemistry 278 (5), 3483-3488, 2003
Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI
KL Longenecker, SM Garrard, PJ Sheffield, ZS Derewenda
Acta Crystallographica Section D: Biological Crystallography 57 (5), 679-688, 2001
Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase
Y Wei, JA Contreras, P Sheffield, T Osterlund, U Derewenda, RE Kneusel, ...
Nature structural biology 6 (4), 340-345, 1999
Molecular basis of mitomycin C resistance in Streptomyces: structure and function of the MRD protein
TW Martin, Z Dauter, Y Devedjiev, P Sheffield, F Jelen, M He, ...
Structure 10 (7), 933-942, 2002
Molecular fabrication
JC Braman, PJ Sheffield, G Fischer
US Patent 10,662,424, 2020
Structure of the BH domain from graf and its implications for Rho GTPase recognition
KL Longenecker, B Zhang, U Derewenda, PJ Sheffield, Z Dauter, ...
Journal of Biological Chemistry 275 (49), 38605-38610, 2000
Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase
YS Ho, PJ Sheffield, J Masuyama, H Arai, J Li, J Aoki, K Inoue, ...
Protein engineering 12 (8), 693-700, 1999
Expression, purification, and crystallization of the RGS-like domain from the Rho nucleotide exchange factor, PDZ-RhoGEF, using the surface entropy reduction approach
SM Garrard, KL Longenecker, ME Lewis, PJ Sheffield, ZS Derewenda
Protein Expression and Purification 21 (3), 412-416, 2001
Homologs of the α‐and β‐subunits of mammalian brain platelet‐activating factor acetylhydrolase Ib in the Drosophila melanogaster genome
PJ Sheffield, S Garrard, M Caspi, J Aoki, H Arai, U Derewenda, K Inoue, ...
Proteins: Structure, Function, and Bioinformatics 39 (1), 1-8, 2000
Preparation and crystal structure of the recombinant α1/α2 catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib
PJ Sheffield, TWP McMullen, J Li, YS Ho, SM Garrard, U Derewenda, ...
Protein engineering 14 (7), 513-519, 2001
The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib)
TWP McMullen, J Li, PJ Sheffield, J Aoki, TW Martin, H Arai, K Inoue, ...
Protein Engineering 13 (12), 865-871, 2000
Expression, purification and crystallization of a BH domain from the GTPase regulatory protein associated with focal adhesion kinase
PJ Sheffield, U Derewenda, J Taylor, TJ Parsons, ZS Derewenda
Acta Crystallographica Section D: Biological Crystallography 55 (1), 356-359, 1999
An integrated strategy for the discovery of drug targets by the analysis of protein–protein interactions
JM Peltier, S Askovic, RR Becklin, CL Chepanoske, YSJ Ho, V Kery, S Lai, ...
International Journal of Mass Spectrometry 238 (2), 119-130, 2004
Seamless assembly of DNA parts into functional devices and higher order multi-device systems
JC Braman, PJ Sheffield
PLoS One 14 (6), e0199653, 2019
A rapid combinatorial approach to assembling synthetic prokaryotic and eukaryotic protein expression vectors
R Mullinax, SE Johns, D Rhodes, V Zhang, N McKinney, KA Felts, ...
Synthetic Biology: Methods and Protocols, 457-468, 2018
Increased Activity of Porcine Pancreatic Phospholipase A2 by Designed Long-Range Electrostatic Stabilization of the Transition State
PJ Sheffield, KM Bhat, AJ Owen, B Perry, IG Sumner, J Warwicker
Biochemical and biophysical research communications 216 (3), 778-784, 1995
Amplifying oligonucleotides and producing libraries of dual guide constructs
JC Braman, PJ Sheffield, H Hogrefe
US Patent 11,718,847, 2023
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