| A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models J Ganz, T Shacham, M Kramer, M Shenkman, H Eiger, N Weinberg, ... Scientific reports 10 (1), 6875, 2020 | 43 | 2020 |
| Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study J Lecka, G Ben-David, L Simhaev, S Eliahu, J Oscar Jr, P Luyindula, ... Journal of Medicinal Chemistry 56 (21), 8308-8320, 2013 | 43 | 2013 |
| Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex ML Bar-El, P Vaňková, A Yeheskel, L Simhaev, H Engel, P Man, Y Haitin, ... Nature Communications 11 (1), 5273, 2020 | 26 | 2020 |
| Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5′-Pα,α-Dithiophosphate Analogues V Zelikman, J Pelletier, L Simhaev, A Sela, FP Gendron, G Arguin, ... Journal of Medicinal Chemistry 61 (9), 3939-3951, 2018 | 26 | 2018 |
| The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue CM Sabusap, D Joshi, L Simhaev, KE Oliver, H Senderowitz, ... Journal of Biological Chemistry 296, 2021 | 25 | 2021 |
| Chemical modifications reduce auditory cell damage induced by aminoglycoside antibiotics SL Zada, BB Baruch, L Simhaev, H Engel, M Fridman Journal of the American Chemical Society 142 (6), 3077-3087, 2020 | 23 | 2020 |
| An ancient CFTR ortholog informs molecular evolution in ABC transporters G Cui, J Hong, YW Chung-Davidson, D Infield, X Xu, J Li, L Simhaev, ... Developmental cell 51 (4), 421-430. e3, 2019 | 18 | 2019 |
| A unique mechanism of inactivation gating of the Kv channel family member Kv7. 1 and its modulation by PIP2 and calmodulin M Lipinsky, WS Tobelaim, A Peretz, L Simhaev, A Yeheskel, ... Science Advances 6 (51), eabd6922, 2020 | 12 | 2020 |
| Exploring the Li+ transporting mutant of NCX_Mj for assigning ion binding sites of mitochondrial NCLX M Giladi, S Mitra, L Simhaev, R Hiller, B Refaeli, T Strauss, CR Baiz, ... Cell calcium 107, 102651, 2022 | 9 | 2022 |
| 2-Hexylthio-β,γ-CH2-ATP is an Effective and Selective NTPDase2 Inhibitor I Gillerman, J Lecka, L Simhaev, MN Munkonda, M Fausther, ... Journal of Medicinal Chemistry 57 (14), 5919-5934, 2014 | 9 | 2014 |
| Molecular dynamics flexible fitting simulations identify new models of the closed state of the cystic fibrosis transmembrane conductance regulator protein L Simhaev, NA McCarty, RC Ford, H Senderowitz Journal of Chemical Information and Modeling 57 (8), 1932-1946, 2017 | 8 | 2017 |
| Chemical chaperones modulate the formation of metabolite assemblies H Adsi, SA Levkovich, E Haimov, T Kreiser, M Meli, H Engel, L Simhaev, ... International Journal of Molecular Sciences 22 (17), 9172, 2021 | 7 | 2021 |
| The Q359K/T360K mutation causes cystic fibrosis in Georgian Jews M Mei-Zahav, P Stafler, H Senderowitz, L Bentur, G Livnat, M Shteinberg, ... Journal of Cystic Fibrosis 17 (5), e41-e45, 2018 | 7 | 2018 |
| Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K+ channels for atrial fibrillation treatment S Burg, S Shapiro, A Peretz, E Haimov, B Redko, A Yeheskel, L Simhaev, ... Proceedings of the National Academy of Sciences 119 (34), e2202926119, 2022 | 6 | 2022 |
| TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission … E Pataki, L Simhaev, H Engel, A Cohen, M Kupiec, R Weisman PLoS Genetics 16 (11), e1009196, 2020 | 4 | 2020 |
| Targeting phenylalanine assemblies as a prospective disease-modifying therapy for phenylketonuria S Shaham-Niv, A Ezra, D Zaguri, SR Shotan, E Haimov, H Engel, T Brider, ... Biophysical Chemistry, 107215, 2024 | | 2024 |
| The contribution of individual residues of an aggregative hexapeptide derived from the human γD-crystallin to its amyloidogenicity M Abu-Hussien, GK Viswanathan, L Simhaev, A Paul, H Engel, E Gazit, ... International Journal of Biological Macromolecules 201, 182-192, 2022 | | 2022 |
| THE STRUCTURE AND DYNAMICS OF WILD-TYPE AND MUTANT CFTR STUDIED BY MOLECULAR SIMULATIONS H Senderowitz, M Zhenin, L Simhaev, MS Bahia, N Khazanov, Z Yang, ... PEDIATRIC PULMONOLOGY 54, S202-S203, 2019 | | 2019 |
| LAMPREY CFTR: AN ANCIENT CFTR ORTHOLOG INFORMS MOLECULAR EVOLUTION IN ABC TRANSPORTERS G Cui, JS Hong, Y Chung-Davidson, D Infield, X Xu, L Simhaev, ... PEDIATRIC PULMONOLOGY 54, S195-S195, 2019 | | 2019 |
| THE DYNAMICS OF WT AND MUTANT CFTR H Senderowitz, M Zhenin, L Simhaev, N Khazanov PEDIATRIC PULMONOLOGY 53, 149-149, 2018 | | 2018 |
