| Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity TM Loo, F Kamachi, Y Watanabe, S Yoshimoto, H Kanda, Y Arai, ... Cancer discovery 7 (5), 522-538, 2017 | 429 | 2017 |
| CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt JH Lim, H Jono, K Komatsu, CH Woo, J Lee, M Miyata, T Matsuno, X Xu, ... Nature communications 3 (1), 771, 2012 | 169 | 2012 |
| Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections JH Lim, B Stirling, J Derry, T Koga, H Jono, CH Woo, H Xu, P Bourne, ... Immunity 27 (2), 349-360, 2007 | 159 | 2007 |
| p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines M Taura, A Eguma, MA Suico, T Shuto, T Koga, K Komatsu, T Komune, ... Molecular and cellular biology 28 (21), 6557-6567, 2008 | 152 | 2008 |
| 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor M Liu, K Saeki, T Matsunobu, T Okuno, T Koga, Y Sugimoto, C Yokoyama, ... Journal of Experimental Medicine 211 (6), 1063-1078, 2014 | 129 | 2014 |
| TGF‐β induces p65 acetylation to enhance bacteria‐induced NF‐κB activation H Ishinaga, H Jono, JH Lim, SM Kweon, H Xu, UH Ha, H Xu, T Koga, ... The EMBO journal 26 (4), 1150-1162, 2007 | 123 | 2007 |
| The crystal structure of the green tea polyphenol (−)-epigallocatechin gallate− transthyretin complex reveals a novel binding site distinct from the thyroxine binding site M Miyata, T Sato, M Kugimiya, M Sho, T Nakamura, S Ikemizu, M Chirifu, ... Biochemistry 49 (29), 6104-6114, 2010 | 109 | 2010 |
| Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice JH Lim, H Jono, T Koga, CH Woo, H Ishinaga, P Bourne, H Xu, UH Ha, ... PloS one 2 (10), e1032, 2007 | 99 | 2007 |
| A novel role for IκB kinase (IKK) α and IKKβ in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae U Ha, JH Lim, H Jono, T Koga, A Srivastava, R Malley, J Pouysségur, ... The Journal of Immunology 178 (3), 1736-1747, 2007 | 94 | 2007 |
| STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein T Sato, Y Sako, M Sho, M Momohara, MA Suico, T Shuto, H Nishitoh, ... Molecular cell 47 (1), 99-110, 2012 | 88 | 2012 |
| Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury T Koga, MA Suico, S Shimasaki, E Watanabe, Y Kai, K Koyama, K Omachi, ... Journal of Biological Chemistry 290 (51), 30366-30374, 2015 | 86 | 2015 |
| TLR3 induction by anticancer drugs potentiates poly I: C‐induced tumor cell apoptosis M Taura, R Fukuda, MA Suico, A Eguma, T Koga, T Shuto, T Sato, ... Cancer science 101 (7), 1610-1617, 2010 | 85 | 2010 |
| Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2 S Iwamoto, T Koga, M Ohba, T Okuno, M Koike, A Murakami, A Matsuda, ... Scientific reports 7 (1), 13267, 2017 | 76 | 2017 |
| Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B F Xu, Z Xu, R Zhang, Z Wu, JH Lim, T Koga, JD Li, H Shen Respiratory research 9, 1-9, 2008 | 76 | 2008 |
| Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD K Komatsu, JY Lee, M Miyata, J Hyang Lim, H Jono, T Koga, H Xu, C Yan, ... Nature communications 4 (1), 1684, 2013 | 68 | 2013 |
| Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling T Koga, JH Lim, H Jono, UH Ha, H Xu, H Ishinaga, S Morino, X Xu, C Yan, ... Journal of Biological Chemistry 283 (18), 12546-12554, 2008 | 62 | 2008 |
| The transforming growth factor-β-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation … F Mikami, JH Lim, H Ishinaga, UH Ha, H Gu, T Koga, H Jono, H Kai, JD Li Journal of Biological Chemistry 281 (31), 22397-22408, 2006 | 61 | 2006 |
| Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins Y Ishii, K Saeki, M Liu, F Sasaki, T Koga, K Kitajima, C Meno, T Okuno, ... The FASEB Journal 30 (2), 933-947, 2016 | 56 | 2016 |
| Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models F Sasaki, T Koga, M Ohba, K Saeki, T Okuno, K Ishikawa, T Nakama, ... JCI insight 3 (18), 2018 | 51 | 2018 |
| Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells S Shimasaki, T Koga, T Shuto, MA Suico, T Sato, K Watanabe, ... Biochemical and biophysical research communications 402 (2), 235-240, 2010 | 45 | 2010 |
