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Leo Hanke
Leo Hanke
Assistant Professor, Karolinska Institutet, Sweden
Verified email at ki.se
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Year
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
PA Koenig, H Das, H Liu, BM KŘmmerer, FN Gohr, LM Jenster, ...
Science 371 (6530), eabe6230, 2021
3402021
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden
AS Rudberg, S Havervall, A Mňnberg, A Jernbom Falk, K Aguilera, H Ng, ...
Nature communications 11 (1), 5064, 2020
3302020
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
L Hanke, L Vidakovics Perez, DJ Sheward, H Das, T Schulte, ...
Nature communications 11 (1), 4420, 2020
3022020
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
TF Custˇdio, H Das, DJ Sheward, L Hanke, S Pazicky, J Pieprzyk, ...
Nature communications 11 (1), 5588, 2020
1542020
Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization
J Ashour, FI Schmidt, L Hanke, J Cragnolini, M Cavallari, A Altenburg, ...
Journal of virology 89 (5), 2792-2800, 2015
662015
Generation of immunity against pathogens via single-domain antibody–antigen constructs
JN Duarte, JJ Cragnolini, LK Swee, AM Bilate, J Bader, JR Ingram, ...
The Journal of Immunology 197 (12), 4838-4847, 2016
652016
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
L Hanke, H Das, DJ Sheward, L Perez Vidakovics, E Urgard, ...
Nature communications 13 (1), 155, 2022
602022
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
M Mandolesi, DJ Sheward, L Hanke, J Ma, P Pushparaj, LP Vidakovics, ...
Cell Reports Medicine 2 (4), 2021
542021
Phenotypic lentivirus screens to identify functional single domain antibodies
FI Schmidt, L Hanke, B Morin, R Brewer, V Brusic, SPJ Whelan, ...
Nature microbiology 1 (8), 1-10, 2016
532016
Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2
N Roxhed, A Bendes, M Dale, C Mattsson, L Hanke, T Dodig-Crnković, ...
Nature Communications 12 (1), 3695, 2021
47*2021
Seropositivity in blood donors and pregnant women during the first year of SARS‐CoV‐2 transmission in Stockholm, Sweden
X Castro Dopico, S Muschiol, M Christian, L Hanke, DJ Sheward, ...
Journal of Internal Medicine, 2021
47*2021
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response
MC Truttmann, X Zheng, L Hanke, JR Damon, M Grootveld, J Krakowiak, ...
Proceedings of the National Academy of Sciences 114 (2), E152-E160, 2017
392017
Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice
K W°rzner, DJ Sheward, ST Schmidt, L Hanke, J Zimmermann, ...
EBioMedicine 63, 2021
382021
Structural basis of Omicron neutralization by affinity-matured public antibodies
DJ Sheward, P Pushparaj, H Das, C Kim, S Kim, L Hanke, R Dyrdak, ...
bioRxiv, 2022.01. 03.474825, 2022
312022
Systematic evaluation of SARS‐CoV‐2 antigens enables a highly specific and sensitive multiplex serological COVID‐19 assay
S Hober, C Hellstr÷m, J Olofsson, E Andersson, S Bergstr÷m, ...
Clinical & Translational Immunology 10 (7), e1312, 2021
312021
Picomolar SARS-CoV-2 neutralization using multi-arm PEG nanobody constructs
A Moliner-Morro, D J. Sheward, V Karl, L Perez Vidakovics, B Murrell, ...
Biomolecules 10 (12), 1661, 2020
312020
The antiviral mechanism of an influenza A virus nucleoprotein-specific single-domain antibody fragment
L Hanke, KE Knockenhauer, RC Brewer, E van Diest, FI Schmidt, ...
MBio 7 (6), 10.1128/mbio. 01569-16, 2016
292016
DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice
I Szurgot, L Hanke, DJ Sheward, LP Vidakovics, B Murrell, GM McInerney, ...
Scientific Reports 11 (1), 3125, 2021
252021
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
DJ Sheward, M Mandolesi, E Urgard, C Kim, L Hanke, LP Vidakovics, ...
Cell Reports Medicine 2 (11), 100450, 2021
242021
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
P Pushparaj, A Nicoletto, DJ Sheward, H Das, XC Dopico, LP Vidakovics, ...
Immunity 56 (1), 193-206. e7, 2023
222023
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