S100 proteins in Alzheimer’s disease JS Cristóvão, CM Gomes Frontiers in Neuroscience 13, 446874, 2019 | 160 | 2019 |
Metals and neuronal metal binding proteins implicated in Alzheimer’s disease JS Cristóvão, R Santos, CM Gomes Oxidative medicine and cellular longevity 2016, 2016 | 155 | 2016 |
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation JS Cristóvão, VK Morris, I Cardoso, SS Leal, J Martínez, HM Botelho, ... Science advances 4 (6), eaaq1702, 2018 | 67 | 2018 |
Aberrant zinc binding to immature conformers of metal-free copper–zinc superoxide dismutase triggers amorphous aggregation SS Leal, JS Cristóvão, A Biesemeier, I Cardoso, CM Gomes Metallomics 7 (2), 333-346, 2015 | 40 | 2015 |
Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain S Hagmeyer, JS Cristóvão, JJE Mulvihill, TM Boeckers, CM Gomes, ... Frontiers in molecular neuroscience 10, 456, 2018 | 37 | 2018 |
Zinc binding to tau influences aggregation kinetics and oligomer distribution GG Moreira, JS Cristóvão, VM Torres, AP Carapeto, MS Rodrigues, ... International Journal of Molecular Sciences 20 (23), 5979, 2019 | 33 | 2019 |
Distribution and relative abundance of S100 proteins in the brain of the APP23 Alzheimer’s disease model mice S Hagmeyer, MA Romão, JS Cristóvão, A Vilella, CM Gomes, ... Frontiers in neuroscience 13, 449573, 2019 | 30 | 2019 |
Glucosylpolyphenols as inhibitors of Aβ-induced Fyn kinase activation and tau phosphorylation: synthesis, membrane permeability, and exploratory target assessment within the … AM De Matos, MT Blazquez-Sanchez, A Bento-Oliveira, RFM de Almeida, ... Journal of medicinal chemistry 63 (20), 11663-11690, 2020 | 24 | 2020 |
Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications C Lopes, J Cristóvão, V Silvério, PR Lino, P Fonte Expert Opinion on Drug Delivery 19 (10), 1381-1395, 2022 | 19 | 2022 |
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding GG Moreira, FX Cantrelle, A Quezada, FS Carvalho, JS Cristóvão, ... Nature communications 12 (1), 6292, 2021 | 19 | 2021 |
Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1) SG Estácio, SS Leal, JS Cristóvão, PFN Faísca, CM Gomes Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1854 (2), 118-126, 2015 | 19 | 2015 |
The S100B alarmin is a dual-function chaperone suppressing amyloid-β oligomerization through combined zinc chelation and inhibition of protein aggregation JS Cristóvão, AJ Figueira, AP Carapeto, MS Rodrigues, I Cardoso, ... ACS Chemical Neuroscience 11 (17), 2753-2760, 2020 | 18 | 2020 |
Biophysical and spectroscopic methods for monitoring protein misfolding and amyloid aggregation JS Cristóvão, BJ Henriques, CM Gomes Protein Misfolding Diseases: Methods and Protocols, 3-18, 2019 | 18 | 2019 |
Synthesis and effects of flavonoid structure variation on amyloid-β aggregation AM Matos, JS Cristovao, DV Yashunsky, NE Nifantiev, AS Viana, ... Pure and Applied Chemistry 89 (9), 1305-1320, 2017 | 16 | 2017 |
S100 proteins in Alzheimer’s disease. Front Neurosci. 2019; 13: 463 JS Cristóvão, CM Gomes | 9 | 2019 |
S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis E Daini, S Hagmeyer, CA De Benedictis, JS Cristóvão, M Bodria, ... Translational Psychiatry 11 (1), 562, 2021 | 8 | 2021 |
Cu 2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation JS Cristóvão, GG Moreira, FEP Rodrigues, AP Carapeto, MS Rodrigues, ... Chemical Communications 57 (3), 379-382, 2021 | 8 | 2021 |
Targeting S100B with peptides encoding intrinsic aggregation-prone sequence segments JS Cristovao, MA Romao, R Gallardo, J Schymkowitz, F Rousseau, ... Molecules 26 (2), 440, 2021 | 7 | 2021 |
Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation JS Cristóvão, SS Leal, I Cardoso, CM Gomes International Journal of Molecular Sciences 14 (9), 19128-19145, 2013 | 5 | 2013 |
Metals and neuronal metal binding proteins implicated in Alzheimer’s disease. Oxid Med Cell Longev. 2016; 2016: 9812178 JS Cristóvão, R Santos, CM Gomes | 5 | |