Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude JS Brenner, DC Pan, JW Myerson, OA Marcos-Contreras, CH Villa, ... Nature communications 9 (1), 2684, 2018 | 292 | 2018 |
Hyperfibrinolysis increases blood–brain barrier permeability by a plasmin-and bradykinin-dependent mechanism OA Marcos-Contreras, S Martinez de Lizarrondo, I Bardou, C Orset, ... Blood, The Journal of the American Society of Hematology 128 (20), 2423-2434, 2016 | 136 | 2016 |
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier OA Marcos-Contreras, CF Greineder, RY Kiseleva, H Parhiz, LR Walsh, ... Proceedings of the National Academy of Sciences 117 (7), 3405-3414, 2020 | 119 | 2020 |
Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes M Gauberti, A Montagne, OA Marcos-Contreras, A Le Béhot, E Maubert, ... Stroke 44 (7), 1988-1996, 2013 | 116 | 2013 |
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation S Zaitsev, D Spitzer, JC Murciano, BS Ding, S Tliba, MA Kowalska, ... Blood, The Journal of the American Society of Hematology 115 (25), 5241-5248, 2010 | 115 | 2010 |
Flexible nanoparticles reach sterically obscured endothelial targets inaccessible to rigid nanoparticles JW Myerson, B Braender, O Mcpherson, PM Glassman, RY Kiseleva, ... Advanced Materials 30 (32), 1802373, 2018 | 82 | 2018 |
Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation JW Myerson, PN Patel, KM Rubey, ME Zamora, MH Zaleski, N Habibi, ... Nature nanotechnology 17 (1), 86-97, 2022 | 64 | 2022 |
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE) H Parhiz, JS Brenner, PN Patel, TE Papp, H Shahnawaz, Q Li, R Shi, ... Journal of Controlled Release 344, 50-61, 2022 | 57 | 2022 |
Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain OA Marcos-Contreras, JS Brenner, RY Kiseleva, V Zuluaga-Ramirez, ... Journal of controlled release 301, 54-61, 2019 | 40 | 2019 |
Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9 M Khoshnejad, JS Brenner, W Motley, H Parhiz, CF Greineder, CH Villa, ... Scientific reports 8 (1), 1760, 2018 | 33 | 2018 |
The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo G Pavani, L Ivanciu, A Faella, OA Marcos-Contreras, P Margaritis Blood, The Journal of the American Society of Hematology 124 (7), 1157-1165, 2014 | 30 | 2014 |
Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII OA Marcos-Contreras, SM Smith, DA Bellinger, RA Raymer, E Merricks, ... Blood, The Journal of the American Society of Hematology 127 (5), 565-571, 2016 | 29 | 2016 |
Dual affinity to RBCs and target cells (DART) enhances both organ-and cell type-targeting of intravascular nanocarriers LT Ferguson, ED Hood, T Shuvaeva, VV Shuvaev, MC Basil, Z Wang, ... ACS nano 16 (3), 4666-4683, 2022 | 28 | 2022 |
Combating complement's deleterious effects on nanomedicine by conjugating complement regulatory proteins to nanoparticles Z Wang, ED Hood, J Nong, J Ding, OA Marcos‐Contreras, PM Glassman, ... Advanced Materials 34 (8), 2107070, 2022 | 26 | 2022 |
Cross-linker-modulated nanogel flexibility correlates with tunable targeting to a sterically impeded endothelial marker JW Myerson, O McPherson, KG DeFrates, JH Towslee, ... ACS nano 13 (10), 11409-11421, 2019 | 26 | 2019 |
Molecularly engineered nanobodies for tunable pharmacokinetics and drug delivery PM Glassman, LR Walsh, CH Villa, OA Marcos-Contreras, ED Hood, ... Bioconjugate chemistry 31 (4), 1144-1155, 2020 | 25 | 2020 |
Vascular endothelial effects of collaborative binding to platelet/endothelial cell adhesion molecule-1 (PECAM-1) RY Kiseleva, CF Greineder, CH Villa, OA Marcos-Contreras, ED Hood, ... Scientific Reports 8 (1), 1510, 2018 | 23 | 2018 |
Clot penetration and retention by plasminogen activators promote fibrinolysis OA Marcos-Contreras, K Ganguly, A Yamamoto, R Shlansky-Goldberg, ... Biochemical pharmacology 85 (2), 216-222, 2013 | 16 | 2013 |
Targeted in vivo loading of red blood cells markedly prolongs nanocarrier circulation PM Glassman, CH Villa, OA Marcos-Contreras, ED Hood, LR Walsh, ... Bioconjugate Chemistry 33 (7), 1286-1294, 2022 | 15 | 2022 |
Bivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo RY Kiseleva, PG Glassman, KM LeForte, LR Walsh, CH Villa, VV Shuvaev, ... FASEB journal: official publication of the Federation of American Societies …, 2020 | 12 | 2020 |