フォロー
Karthika Natarajan
Karthika Natarajan
確認したメール アドレス: som.umaryland.edu
タイトル
引用先
引用先
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
K Natarajan, Y Xie, MR Baer, DD Ross
Biochemical pharmacology 83 (8), 1084-1103, 2012
4722012
Chemopreventive effects of dietary flaxseed oil on colon tumor development
C Dwivedi, K Natarajan, DP Matthees
Nutrition and cancer 51 (1), 52-58, 2005
1252005
The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent …
K Natarajan, J Bhullar, S Shukla, M Burcu, ZS Chen, SV Ambudkar, ...
Biochemical pharmacology 85 (4), 514-524, 2013
982013
The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2
R Sen, K Natarajan, J Bhullar, S Shukla, HB Fang, L Cai, ZS Chen, ...
Molecular cancer therapeutics 11 (9), 2033-2044, 2012
982012
Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication
K Natarajan, Y Xie, M Burcu, DE Linn, Y Qiu, MR Baer
PloS one 8 (9), e74653, 2013
712013
Concurrent inhibition of Pim and FLT3 kinases enhances apoptosis of FLT3-ITD acute myeloid leukemia cells through increased Mcl-1 proteasomal degradation
S Kapoor, K Natarajan, PR Baldwin, KA Doshi, RG Lapidus, TJ Mathias, ...
Clinical Cancer Research 24 (1), 234-247, 2018
352018
The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions
J Bhullar, K Natarajan, S Shukla, TJ Mathias, M Sadowska, SV Ambudkar, ...
PloS one 8 (8), e71266, 2013
332013
The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant …
TJ Mathias, K Natarajan, S Shukla, KA Doshi, ZN Singh, SV Ambudkar, ...
Investigational new drugs 33, 300-309, 2015
242015
Identification and characterization of the major alternative promoter regulating Bcrp1/Abcg2 expression in the mouse intestine
K Natarajan, Y Xie, T Nakanishi, WT Beck, KS Bauer, DD Ross
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1809 (7), 295-305, 2011
192011
Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
KA Doshi, R Trotta, K Natarajan, FV Rassool, AE Tron, D Huszar, ...
Oncotarget 7 (30), 48280, 2016
182016
Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway-or androgen withdrawal …
Y Xie, T Nakanishi, K Natarajan, L Safren, AW Hamburger, A Hussain, ...
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (3), 317-327, 2015
172015
Antioxidant and protective effects of Amrit Nectar tablets on adriamycin-and cisplatin-induced toxicities
C Dwivedi, P Agrawal, K Natarajan, H Sharma
Journal of Alternative & Complementary Medicine 11 (1), 143-148, 2005
162005
Role of breast cancer resistance protein (BCRP, ABCG2) in cancer outcomes and drug resistance
K Natarajan, MR Baer, DD Ross
Resistance to targeted ABC transporters in cancer, 53-88, 2015
112015
Hydroxylated dimeric naphthoquinones increase the generation of reactive oxygen species, induce apoptosis of acute myeloid leukemia cells and are not substrates of the …
RG Lapidus, BA Carter-Cooper, M Sadowska, EY Choi, O Wonodi, ...
Pharmaceuticals 9 (1), 4, 2016
92016
Toxicokinetic study of recombinant human heparin-binding epidermal growth factor-like growth factor (rhHB-EGF) in female Sprague Dawley rats
I Coowanitwong, SK Keay, K Natarajan, TS Garimella, CW Mason, ...
Pharmaceutical research 25, 542-550, 2008
72008
Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1
Y Xie, K Natarajan, KS Bauer, T Nakanishi, WT Beck, RS Moreci, ...
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1829 (12 …, 2013
62013
Methods to discover alternative promoter usage and transcriptional regulation of murine Bcrp1
K Natarajan, Y Xie, T Nakanishi, RS Moreci, P Jeyasuria, A Hussain, ...
JoVE (Journal of Visualized Experiments), e53827, 2016
32016
Concurrent inhibition of Pim-1 and FLT3 kinases in FLT3-ITD acute myeloid leukemia post-translationally downregulates the anti-apoptotic protein Mcl-1 through downregulation of …
PR Baldwin, S Kapoor, K Natarajan, R Trotta, A Tron, D Huszar, E Davila, ...
Blood 128 (22), 35, 2016
22016
The pim kinase inhibitor AZD1208 enhances apoptosis induction by clinically active FLT3 inhibitors in FLT3-ITD acute myeloid leukemia cells in vitro and in vivo through …
K Natarajan, TJ Mathias, KA Doshi, AE Tron, M Kraus, R Trotta, D Perrotti, ...
Blood 124 (21), 3601, 2014
22014
Chemopreventive effects of alpha-santalol on UVB-induced skin carcinogenesis
K Natarajan, HB Valluri, XM Guan, C Dwivedi
FASEB JOURNAL 17 (5), A1064-A1064, 2003
22003
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