Paul Thornalley
Paul Thornalley
Qatar Biomedical Research Institute
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Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
PJ Thornalley, M Vašįk
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 1985
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
PJ Thornalley, A Langborg, HS Minhas
Biochemical Journal 344 (1), 109-116, 1999
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
PJ Thornalley
Biochemical Journal 269 (1), 1, 1990
Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N …
TW Lo, ME Westwood, AC McLellan, T Selwood, PJ Thornalley
Journal of Biological Chemistry 269 (51), 32299-32305, 1994
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-a role in pathogenesis and antiproliferative chemotherapy
PJ Thornalley
General Pharmacology: The Vascular System 27 (4), 565-573, 1996
Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry
PJ Thornalley, S Battah, N Ahmed, N Karachalias, S Agalou, ...
Biochemical Journal 375 (3), 581-592, 2003
Glyoxalase I–structure, function and a critical role in the enzymatic defence against glycation
PJ Thornalley
Biochemical Society Transactions 31 (6), 1343-1348, 2003
Unraveling the biological roles of reactive oxygen species
MP Murphy, A Holmgren, NG Larsson, B Halliwell, CJ Chang, ...
Cell metabolism 13 (4), 361-366, 2011
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications
AC McLellan, PJ Thornalley, J Benn, PH Sonksen
Clinical Science 87 (1), 21-29, 1994
Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts
PJ Thornalley
Archives of biochemistry and biophysics 419 (1), 31-40, 2003
The glyoxalase system in health and disease
PJ Thornalley
Molecular aspects of medicine 14 (4), 287-371, 1993
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in …
M Shinohara, PJ Thornalley, I Giardino, P Beisswenger, SR Thorpe, ...
The Journal of clinical investigation 101 (5), 1142-1147, 1998
The formation of methylglyoxal from triose phosphates: investigation using a specific assay for methylglyoxal
European journal of biochemistry 212 (1), 101-105, 1993
Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs.
PJ Thornalley
Cellular and molecular biology (Noisy-le-Grand, France) 44 (7), 1013-1023, 1998
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine
R Babaei-Jadidi, N Karachalias, N Ahmed, S Battah, PJ Thornalley
Diabetes 52 (8), 2110-2120, 2003
Advanced glycation endproducts: what is their relevance to diabetic complications?
N Ahmed, PJ Thornalley
Diabetes, Obesity and Metabolism 9 (3), 233-245, 2007
Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems-role in ageing and disease
PJ Thornalley
Drug metabolism and drug interactions 23 (1-2), 125, 2008
Dicarbonyl intermediates in the Maillard reaction
PJ Thornalley
Annals of the New York Academy of Sciences 1043 (1), 111-117, 2005
Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
A Bierhaus, T Fleming, S Stoyanov, A Leffler, A Babes, C Neacsu, ...
Nature medicine 18 (6), 926-933, 2012
Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application …
N Ahmed, OK Argirov, HS Minhas, CAA Cordeiro, PJ Thornalley
Biochemical Journal 364 (1), 1-14, 2002
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