Christoph Garbers
Christoph Garbers
Institute of Pathology, Otto-von-Guericke University Magdeburg, Germany
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ADAM17: a molecular switch to control inflammation and tissue regeneration
J Scheller, A Chalaris, C Garbers, S Rose-John
Trends in immunology 32 (8), 380-387, 2011
Interleukin-6 and its receptors: a highly regulated and dynamic system
J Wolf, S Rose-John, C Garbers
Cytokine 70 (1), 11-20, 2014
Plasticity and cross-talk of Interleukin 6-type cytokines
C Garbers, HM Hermanns, F Schaper, G Müller-Newen, J Grötzinger, ...
Cytokine & Growth Factor Reviews, 2012
The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition
C Garbers, S Aparicio-Siegmund, S Rose-John
Current Opinion in Immunology 34, 75-82, 2015
The soluble Interleukin 6 receptor: generation and role in inflammation and cancer
A Chalaris, C Garbers, B Rabe, S Rose-John, J Scheller
European journal of cell biology 90 (6), 484-494, 2011
Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities
J Scheller, C Garbers, S Rose-John
Seminars in immunology 26 (1), 2-12, 2014
Interleukin-6: designing specific therapeutics for a complex cytokine
C Garbers, S Heink, T Korn, S Rose-John
Nature Reviews Drug Discovery 17 (6), 395-412, 2018
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH 17 cells
S Heink, N Yogev, C Garbers, M Herwerth, L Aly, C Gasperi, V Husterer, ...
Nature immunology 18 (1), 74-85, 2017
Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding
C Garbers, N Jänner, A Chalaris, ML Moss, DM Floss, D Meyer, ...
Journal of Biological Chemistry 286 (17), 14804, 2011
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor
C Garbers, W Thaiss, GW Jones, GH Waetzig, I Lorenzen, F Guilhot, ...
Journal of Biological Chemistry 286 (50), 42959-42970, 2011
Interleukin-6 and interleukin-11: same same but different
C Garbers, J Scheller
Biological chemistry 394 (9), 1145-1161, 2013
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 receptor homodimer
C Garbers, B Spudy, S Aparicio-Siegmund, GH Waetzig, J Sommer, ...
Journal of Biological Chemistry, 2012
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases
C Garbers, N Monhasery, S Aparicio-Siegmund, J Lokau, P Baran, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (9 …, 2014
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to …
N Schumacher, D Meyer, A Mauermann, J von der Heyde, J Wolf, ...
Journal of Biological Chemistry 290 (43), 26059-26071, 2015
The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II
I Lorenzen, J Lokau, S Düsterhöft, A Trad, C Garbers, J Scheller, ...
FEBS Letters, 2012
IL-6< i> trans</i>-Signaling-Dependent Rapid Development of Cytotoxic CD8< sup>+</sup> T Cell Function
JP Böttcher, O Schanz, C Garbers, A Zaremba, S Hegenbarth, C Kurts, ...
Cell Reports, 2014
A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)
K Möller-Hackbarth, C Dewitz, O Schweigert, A Trad, C Garbers, ...
Journal of Biological Chemistry 288 (48), 34529-34544, 2013
Minimal interleukin (IL-) 6 receptor stalk composition for IL-6R shedding and IL-6 classic signaling
P Baran, R Nitz, J Grötzinger, J Scheller, C Garbers
Journal of Biological Chemistry, 2013
A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor
S Düsterhöft, K Höbel, M Oldefest, J Lokau, GH Waetzig, A Chalaris, ...
Journal of Biological Chemistry 289 (23), 16336-16348, 2014
Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation
S Riethmueller, P Somasundaram, JC Ehlers, CW Hung, CM Flynn, ...
PLoS biology 15 (1), e2000080, 2017
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