フォロー
Ladie Kimberly De La Cruz
Ladie Kimberly De La Cruz
Assistant Professor, Presbyterian College
確認したメール アドレス: presby.edu
タイトル
引用先
引用先
Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide
Y Zheng, X Ji, B Yu, K Ji, D Gallo, E Csizmadia, M Zhu, MR Choudhury, ...
Nature chemistry 10 (7), 787-794, 2018
2312018
Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs
X Ji, Z Pan, B Yu, LK De La Cruz, Y Zheng, B Ke, B Wang
Chemical Society Reviews 48 (4), 1077-1094, 2019
2292019
Toward hydrogen sulfide based therapeutics: critical drug delivery and developability issues
Y Zheng, B Yu, LK De La Cruz, M Roy Choudhury, A Anifowose, B Wang
Medicinal Research Reviews 38 (1), 57-100, 2018
1642018
Strategies to target the Hedgehog signaling pathway for cancer therapy
M Xin, X Ji, LK De La Cruz, S Thareja, B Wang
Medicinal Research Reviews 38 (3), 870-913, 2018
1002018
Toward direct protein S-persulfidation: a prodrug approach that directly delivers hydrogen persulfide
B Yu, Y Zheng, Z Yuan, S Li, H Zhu, LK De La Cruz, J Zhang, K Ji, S Wang, ...
Journal of the American Chemical Society 140 (1), 30-33, 2018
772018
pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates
X Ji, LKC De La Cruz, Z Pan, V Chittavong, B Wang
Chemical communications 53 (69), 9628-9631, 2017
702017
Esterase-sensitive and pH-controlled carbon monoxide prodrugs for treating systemic inflammation
X Ji, Z Pan, C Li, T Kang, LKC De La Cruz, L Yang, Z Yuan, B Ke, B Wang
Journal of Medicinal Chemistry 62 (6), 3163-3168, 2019
602019
Click, release, and fluoresce: a chemical strategy for a cascade prodrug system for codelivery of carbon monoxide, a drug payload, and a fluorescent reporter
LKC De La Cruz, SL Benoit, Z Pan, B Yu, RJ Maier, X Ji, B Wang
Organic letters 20 (4), 897-900, 2018
532018
Role of carbon monoxide in host–gut microbiome communication
CP Hopper, LK De La Cruz, KV Lyles, LK Wareham, JA Gilbert, ...
Chemical Reviews 120 (24), 13273-13311, 2020
502020
Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety
Z Yuan, X Yang, LK De La Cruz, B Wang
Chemical communications 56 (14), 2190-2193, 2020
482020
Click and release: a high-content bioorthogonal prodrug with multiple outputs
X Ji, RE Aghoghovbia, LKC De La Cruz, Z Pan, X Yang, B Yu, B Wang
Organic letters 21 (10), 3649-3652, 2019
342019
Towards “CO in a pill”: Pharmacokinetic studies of carbon monoxide prodrugs in mice
M Wang, X Yang, Z Pan, Y Wang, LK De La Cruz, B Wang, C Tan
Journal of controlled release 327, 174-185, 2020
302020
Adapting decarbonylation chemistry for the development of prodrugs capable of in vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules
LK De La Cruz, X Yang, A Menshikh, M Brewer, W Lu, M Wang, S Wang, ...
Chemical Science 12 (31), 10649-10654, 2021
282021
Carbon monoxide signaling: Examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response
Z Yuan, LK De La Cruz, X Yang, B Wang
Pharmacological Reviews 74 (3), 825-875, 2022
162022
Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs
AB Draganov, X Yang, A Anifowose, LKC De La Cruz, C Dai, N Ni, ...
Bioorganic & medicinal chemistry 27 (17), 3860-3865, 2019
162019
Activated charcoal dispersion of carbon monoxide prodrugs for oral delivery of CO in a pill
X Yang, W Lu, M Wang, LK De La Cruz, C Tan, B Wang
International journal of pharmaceutics 618, 121650, 2022
72022
Light-activated CO donor as a universal CO surrogate for Pd-catalyzed and light-mediated carbonylation
LK De La Cruz, N Bauer, A Cachuela, WS Tam, R Tripathi, X Yang, ...
Organic letters 24 (27), 4902-4907, 2022
62022
Click, release, and fluoresce: in-vivo generation of CO with concomitant synthesis of a fluorescent reporter
LK De La Cruz, X Ji, X Yang, B Wang
Bioorganic & Medicinal Chemistry 44, 116297, 2021
32021
Endogenous CO production in sickness and in health
LK De La Cruz, B Wang
Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic …, 2022
12022
Caging Carbon Monoxide For Therapeutic Applications And Carbonylation Reactions
LKC De La Cruz
2020
現在システムで処理を実行できません。しばらくしてからもう一度お試しください。
論文 1–20