| SARS-CoV-2 infection of pluripotent stem cell-derived human lung alveolar type 2 cells elicits a rapid epithelial-intrinsic inflammatory response J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta-Martin, ... Cell Stem Cell 27 (6), 962-973. e7, 2020 | 324 | 2020 |
| Reconstructed single-cell fate trajectories define lineage plasticity windows during differentiation of human PSC-derived distal lung progenitors K Hurley, J Ding, C Villacorta-Martin, MJ Herriges, A Jacob, M Vedaie, ... Cell stem cell 26 (4), 593-608. e8, 2020 | 119 | 2020 |
| Respiratory syncytial virus infection promotes necroptosis and HMGB1 release by airway epithelial cells J Simpson, Z Loh, MA Ullah, JP Lynch, RB Werder, N Collinson, V Zhang, ... American journal of respiratory and critical care medicine 201 (11), 1358-1371, 2020 | 104 | 2020 |
| Actionable cytopathogenic host responses of human alveolar type 2 cells to SARS-CoV-2 RM Hekman, AJ Hume, RK Goel, KM Abo, J Huang, BC Blum, RB Werder, ... Molecular cell 80 (6), 1104-1122. e9, 2020 | 94 | 2020 |
| Characterization of the COPD alveolar niche using single-cell RNA sequencing M Sauler, JE McDonough, TS Adams, N Kothapalli, T Barnthaler, ... Nature communications 13 (1), 494, 2022 | 93 | 2022 |
| Aeroallergen-induced IL-33 predisposes to respiratory virus–induced asthma by dampening antiviral immunity JP Lynch, RB Werder, J Simpson, Z Loh, V Zhang, A Haque, K Spann, ... Journal of Allergy and Clinical Immunology 138 (5), 1326-1337, 2016 | 91 | 2016 |
| Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a–mediated T reg expansion JP Lynch, RB Werder, Z Loh, MAA Sikder, B Curren, V Zhang, MJ Rogers, ... Journal of Experimental Medicine 215 (2), 537-557, 2018 | 71 | 2018 |
| Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity RB Werder, V Zhang, JP Lynch, N Snape, JW Upham, K Spann, S Phipps Journal of Allergy and Clinical Immunology 141 (5), 1607-1619. e9, 2018 | 69 | 2018 |
| Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling MAR Ferreira, R Jansen, G Willemsen, B Penninx, LM Bain, CT Vicente, ... Journal of Allergy and Clinical Immunology 139 (4), 1148-1157, 2017 | 68 | 2017 |
| Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors KM Abo, L Ma, T Matte, J Huang, KD Alysandratos, RB Werder, A Mithal, ... Biorxiv, 2020 | 58 | 2020 |
| PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production RB Werder, JP Lynch, JC Simpson, V Zhang, NH Hodge, M Poh, ... Science translational medicine 10 (440), eaao0052, 2018 | 57 | 2018 |
| The influence of the microbiome on early-life severe viral lower respiratory infections and asthma—food for thought? JP Lynch, MAA Sikder, BF Curren, RB Werder, J Simpson, PÓ Cuív, ... Frontiers in immunology 8, 247439, 2017 | 44 | 2017 |
| HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling Z Loh, J Simpson, A Ullah, V Zhang, WJ Gan, JP Lynch, RB Werder, ... PLoS pathogens 16 (7), e1008651, 2020 | 37 | 2020 |
| Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma RB Werder, MA Ullah, MM Rahman, J Simpson, JP Lynch, N Collinson, ... American Journal of Respiratory and Critical Care Medicine 205 (3), 300-312, 2022 | 34 | 2022 |
| RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma J Arikkatt, MA Ullah, KR Short, V Zhang, WJ Gan, Z Loh, RB Werder, ... Elife 6, e21199, 2017 | 30 | 2017 |
| Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection MAA Sikder, RB Rashid, T Ahmed, I Sebina, DR Howard, MA Ullah, ... Immunity 56 (5), 1098-1114. e10, 2023 | 28 | 2023 |
| IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice KM Spann, Z Loh, JP Lynch, A Ullah, V Zhang, E Baturcam, RB Werder, ... The American journal of pathology 184 (6), 1795-1806, 2014 | 26 | 2014 |
| Coinfection with blood-stage Plasmodium promotes systemic type I interferon production during pneumovirus infection but impairs inflammation and viral control in the lung CL Edwards, V Zhang, RB Werder, SE Best, I Sebina, KR James, ... Clinical and vaccine immunology 22 (5), 477-483, 2015 | 24 | 2015 |
| Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium KM Abo, JS de Aja, J Lindstrom-Vautrin, KD Alysandratos, A Richards, ... JCI insight 7 (6), 2022 | 22 | 2022 |
| Actionable cytopathogenic host responses of human alveolar type 2 cells to SARS-CoV-2 RM Hekman, AJ Hume, RK Goel, KM Abo, J Huang, BC Blum, RB Werder, ... Molecular cell 81 (1), 212, 2021 | 19 | 2021 |
