Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules CP Briscoe, AJ Peat, SC McKeown, DF Corbett, AS Goetz, TR Littleton, ... British journal of pharmacology 148 (5), 619-628, 2006 | 481 | 2006 |
Open-air alkylation reactions in photoredox-catalyzed DNA-encoded library synthesis JP Phelan, SB Lang, J Sim, S Berritt, AJ Peat, K Billings, L Fan, ... Journal of the American Chemical Society 141 (8), 3723-3732, 2019 | 254 | 2019 |
Novel syntheses of tetrahydropyrroloquinolines: Applications to alkaloid synthesis AJ Peat, SL Buchwald Journal of the American Chemical Society 118 (5), 1028-1030, 1996 | 167 | 1996 |
Synthesis and activity of small molecule GPR40 agonists DM Garrido, DF Corbett, KA Dwornik, AS Goetz, TR Littleton, ... Bioorganic & Medicinal Chemistry Letters 16 (7), 1840-1845, 2006 | 153 | 2006 |
Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor SC McKeown, DF Corbett, AS Goetz, TR Littleton, E Bigham, CP Briscoe, ... Bioorganic & medicinal chemistry letters 17 (6), 1584-1589, 2007 | 90 | 2007 |
Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors AJ Peat, JA Boucheron, SH Dickerson, D Garrido, W Mills, J Peckham, ... Bioorganic & medicinal chemistry letters 14 (9), 2121-2125, 2004 | 90 | 2004 |
Titanocene-based method for indole synthesis K Aoki, AJ Peat, SL Buchwald Journal of the American Chemical Society 120 (13), 3068-3073, 1998 | 71 | 1998 |
Potent, selective, and orally efficacious antagonists of melanin-concentrating hormone receptor 1 FX Tavares, KA Al-Barazanji, EC Bigham, MJ Bishop, CS Britt, DL Carlton, ... Journal of medicinal chemistry 49 (24), 7095-7107, 2006 | 70 | 2006 |
Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3 TL Smalley Jr, AJ Peat, JA Boucheron, S Dickerson, D Garrido, ... Bioorganic & medicinal chemistry letters 16 (8), 2091-2094, 2006 | 64 | 2006 |
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists DL Hertzog, KA Al-Barazanji, EC Bigham, MJ Bishop, CS Britt, DL Carlton, ... Bioorganic & medicinal chemistry letters 16 (18), 4723-4727, 2006 | 62 | 2006 |
Novel GSK-3 inhibitors with improved cellular activity AJ Peat, D Garrido, JA Boucheron, SL Schweiker, SH Dickerson, ... Bioorganic & medicinal chemistry letters 14 (9), 2127-2130, 2004 | 62 | 2004 |
Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase P Chong, P Sebahar, M Youngman, D Garrido, H Zhang, EL Stewart, ... Journal of medicinal chemistry 55 (23), 10601-10609, 2012 | 60 | 2012 |
Hepatitis C replication inhibitors that target the viral NS4B protein JF Miller, PY Chong, JB Shotwell, JG Catalano, VWF Tai, J Fang, ... Journal of medicinal chemistry 57 (5), 2107-2120, 2014 | 59 | 2014 |
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase A Maynard, RM Crosby, B Ellis, R Hamatake, Z Hong, BA Johns, ... Journal of Medicinal Chemistry 57 (5), 1902-1913, 2014 | 57 | 2014 |
Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization JB Shotwell, S Baskaran, P Chong, KL Creech, RM Crosby, H Dickson, ... ACS Medicinal Chemistry Letters 3 (7), 565-569, 2012 | 55 | 2012 |
Synthesis and reactions of 3-(bromomethyl)-1-carbethoxy-4-iodoindole: The preparation of 3, 4-differentially substituted indoles JH Tidwell, AJ Peat, SL Buchwald The Journal of Organic Chemistry 59 (23), 7164-7168, 1994 | 55 | 1994 |
Pyrazolopyrimidines as kinase inhibitors S Dickerson, D Garrido, W Mills, K Kano, A Peat, S Thomson, J Wilson, ... US Patent App. 10/521,909, 2006 | 53 | 2006 |
Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor PY Chong, JB Shotwell, J Miller, DJ Price, A Maynard, C Voitenleitner, ... Journal of Medicinal Chemistry 62 (7), 3254-3267, 2019 | 51 | 2019 |
Multi-modal imaging with a toolbox of influenza A reporter viruses V Tran, DS Poole, JJ Jeffery, TP Sheahan, D Creech, A Yevtodiyenko, ... Viruses 7 (10), 5319-5327, 2015 | 43 | 2015 |
A Combined Zirconocene Benzyne− Palladium Cross-Coupling Route to Substituted Biphenyls and Terphenyls M Frid, D Perez, AJ Peat, SL Buchwald Journal of the American Chemical Society 121 (40), 9469-9470, 1999 | 41 | 1999 |