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Lei Duan
Lei Duan
Assistant professor, Rush University Medical Center
Verified email at rush.edu
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Cited by
Cited by
Year
Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis
L Duan, Y Miura, M Dimri, B Majumder, IL Dodge, AL Reddi, A Ghosh, ...
Journal of Biological Chemistry 278 (31), 28950-28960, 2003
2722003
The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling
L Duan, AL Reddi, A Ghosh, M Dimri, H Band
Immunity 21 (1), 7-17, 2004
1642004
Cytosolic phospholipase A2 participates with TNF-α in the induction of apoptosis of human macrophages infected with Mycobacterium tuberculosis H37Ra
L Duan, H Gan, J Arm, HG Remold
The Journal of Immunology 166 (12), 7469-7476, 2001
1382001
Critical role of mitochondrial damage in determining outcome of macrophage infection with Mycobacterium tuberculosis
L Duan, H Gan, DE Golan, HG Remold
The Journal of Immunology 169 (9), 5181-5187, 2002
1112002
Modeling breast cancer–associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive …
M Dimri, M Naramura, L Duan, J Chen, C Ortega-Cava, G Chen, ...
Cancer research 67 (9), 4164-4172, 2007
1052007
Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
SM Raja, RJ Clubb, C Ortega-Cava, SH Williams, TA Bailey, L Duan, ...
Cancer biology & therapy 11 (2), 263-276, 2011
822011
Cbl-mediated ubiquitinylation and negative regulation of Vav
Y Miura-Shimura, L Duan, NL Rao, AL Reddi, H Shimura, R Rottapel, ...
Journal of Biological Chemistry 278 (40), 38495-38504, 2003
792003
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCγ1 activation and angiogenesis
AJ Singh, RD Meyer, G Navruzbekov, R Shelke, L Duan, H Band, ...
Proceedings of the National Academy of Sciences 104 (13), 5413-5418, 2007
752007
Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential
H Gan, X He, L Duan, E Mirabile-Levens, H Kornfeld, HG Remold
The Journal of infectious diseases 191 (8), 1292-1300, 2005
632005
Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration
L Duan, SM Raja, G Chen, S Virmani, SH Williams, RJ Clubb, ...
Journal of biological chemistry 286 (1), 620-633, 2011
562011
Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells
X Zhao, L Lu, N Pokhriyal, H Ma, L Duan, S Lin, N Jafari, H Band, V Band
Cancer research 69 (2), 483-491, 2009
552009
p53-regulated autophagy is controlled by glycolysis and determines cell fate
L Duan, RE Perez, B Davaadelger, EN Dedkova, LA Blatter, CG Maki
Oncotarget 6 (27), 23135, 2015
522015
Binding of Cbl to a phospholipase Cγ1-docking site on platelet-derived growth factor receptor β provides a dual mechanism of negative regulation
AL Reddi, GG Ying, L Duan, G Chen, M Dimri, P Douillard, BJ Druker, ...
Journal of biological chemistry 282 (40), 29336-29347, 2007
522007
Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells
L Duan, N Motchoulski, B Danzer, I Davidovich, Z Shariat-Madar, ...
Journal of biological chemistry 286 (4), 2864-2876, 2011
432011
Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1
L Duan, RE Perez, M Hansen, S Gitelis, CG Maki
Cancer biology & therapy 15 (12), 1600-1612, 2014
352014
Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture
L Duan, G Chen, S Virmani, GG Ying, SM Raja, BM Chung, MA Rainey, ...
Journal of biological chemistry 285 (2), 1555-1568, 2010
342010
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT
L Duan, G Ying, B Danzer, RE Perez, Z Shariat-Madar, VV Levenson, ...
Journal of Biological Chemistry 289 (31), 21694-21705, 2014
302014
The IGF-1R/AKT pathway determines cell fate in response to p53
L Duan, CG Maki
Translational cancer research 5 (6), 664, 2016
292016
Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor
B Davaadelger, L Duan, RE Perez, S Gitelis, CG Maki
Oncotarget 7 (19), 27511, 2016
282016
Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase
AK Ghosh, AL Reddi, NL Rao, L Duan, V Band, H Band
Journal of Biological Chemistry 279 (34), 36132-36141, 2004
282004
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Articles 1–20