| Structural basis for transcription regulation by alarmone ppGpp I Artsimovitch, V Patlan, S Sekine, MN Vassylyeva, T Hosaka, K Ochi, ... Cell 117 (3), 299-310, 2004 | 387 | 2004 |
| New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters K Ochi, T Hosaka Applied microbiology and biotechnology 97, 87-98, 2013 | 351 | 2013 |
| Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12 T Hosaka, M Ohnishi-Kameyama, H Muramatsu, K Murakami, Y Tsurumi, ... Nature biotechnology 27 (5), 462-464, 2009 | 276 | 2009 |
| Ribosome engineering and secondary metabolite production K Ochi, S Okamoto, Y Tozawa, T Inaoka, T Hosaka, J Xu, K Kurosawa Advances in applied microbiology 56 (56), 155-179, 2004 | 213 | 2004 |
| Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations G Wang, T Hosaka, K Ochi Applied and Environmental Microbiology 74 (9), 2834-2840, 2008 | 176 | 2008 |
| Enhanced Expression of S-Adenosylmethionine Synthetase Causes Overproduction of Actinorhodin in Streptomyces coelicolor A3(2) S Okamoto, A Lezhava, T Hosaka, Y Okamoto-Hosoya, K Ochi Journal of Bacteriology 185 (2), 601-609, 2003 | 173 | 2003 |
| Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3 (2) Y Tanaka, T Hosaka, K Ochi The Journal of antibiotics 63 (8), 477-481, 2010 | 138 | 2010 |
| Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3 (2) K Nishimura, T Hosaka, S Tokuyama, S Okamoto, K Ochi Journal of bacteriology 189 (10), 3876-3883, 2007 | 133 | 2007 |
| Innovative Approach for Improvement of an Antibiotic-Overproducing Industrial Strain of Streptomyces albus N Tamehiro, T Hosaka, J Xu, H Hu, N Otake, K Ochi Applied and environmental microbiology 69 (11), 6412-6417, 2003 | 133 | 2003 |
| The novel mutation K87E in ribosomal protein S12 enhances protein synthesis activity during the late growth phase in Escherichia coli T Hosaka, N Tamehiro, N Chumpolkulwong, C Hori-Takemoto, ... Molecular Genetics and Genomics 271, 317-324, 2004 | 116 | 2004 |
| Increased expression of ribosome recycling factor is responsible for the enhanced protein synthesis during the late growth phase in an antibiotic‐overproducing Streptomyces … T Hosaka, J Xu, K Ochi Molecular microbiology 61 (4), 883-897, 2006 | 101 | 2006 |
| Lincomycin at subinhibitory concentrations potentiates secondary metabolite production by Streptomyces spp Y Imai, S Sato, Y Tanaka, K Ochi, T Hosaka Applied and environmental microbiology 81 (11), 3869-3879, 2015 | 73 | 2015 |
| An aberrant protein synthesis activity is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2) Y Okamoto-Hosoya, T Hosaka, K Ochi Microbiology 149 (11), 3299-3309, 2003 | 70 | 2003 |
| Improvement of α-Amylase Production by Modulation of Ribosomal Component Protein S12 in Bacillus subtilis 168 K Kurosawa, T Hosaka, N Tamehiro, T Inaoka, K Ochi Applied and environmental microbiology 72 (1), 71-77, 2006 | 69 | 2006 |
| Identification of the RsmG Methyltransferase Target as 16S rRNA Nucleotide G527 and Characterization of Bacillus subtilis rsmG Mutants K Nishimura, SK Johansen, T Inaoka, T Hosaka, S Tokuyama, Y Tahara, ... Journal of bacteriology 189 (16), 6068-6073, 2007 | 61 | 2007 |
| Physiological Analysis of the Stringent Response Elicited in an Extreme Thermophilic Bacterium, Thermus thermophilus K Kasai, T Nishizawa, K Takahashi, T Hosaka, H Aoki, K Ochi Journal of bacteriology 188 (20), 7111-7122, 2006 | 60 | 2006 |
| Effects of Escherichia coli ribosomal protein S12 mutations on cell‐free protein synthesis N Chumpolkulwong, C Hori‐Takemoto, T Hosaka, T Inaoka, T Kigawa, ... European journal of biochemistry 271 (6), 1127-1134, 2004 | 56 | 2004 |
| Bacterial Alarmone, Guanosine 5′‐Diphosphate 3′‐Diphosphate (ppGpp), Predominantly Binds the β′ Subunit of Plastid‐Encoded Plastid RNA Polymerase in Chloroplasts M Sato, K Takahashi, Y Ochiai, T Hosaka, K Ochi, K Nabeta Chembiochem 10 (7), 1227-1233, 2009 | 52 | 2009 |
| EshA Accentuates ppGpp Accumulation and Is Conditionally Required for Antibiotic Production in Streptomyces coelicolor A3(2) N Saito, J Xu, T Hosaka, S Okamoto, H Aoki, MJ Bibb, K Ochi Journal of bacteriology 188 (13), 4952-4961, 2006 | 40 | 2006 |
| Discovery of a new mechanism of 2, 3-butanediol stereoisomer formation in Bacillus cereus YUF-4 S Ui, T Hosaka, K Watanabe, A Mimura Journal of fermentation and bioengineering 85 (1), 79-83, 1998 | 34 | 1998 |
Susumu OkamotoFood Research Institute, NAROVerified email at affrc.go.jp
