Proteome-wide covalent ligand discovery in native biological systems KM Backus, BE Correia, KM Lum, S Forli, BD Horning, GE González-Páez, ... Nature 534 (7608), 570-574, 2016 | 735 | 2016 |
Global profiling of lysine reactivity and ligandability in the human proteome SM Hacker, KM Backus, MR Lazear, S Forli, BE Correia, BF Cravatt Nature chemistry 9 (12), 1181-1190, 2017 | 377 | 2017 |
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis KM Backus, HI Boshoff, CS Barry, O Boutureira, MK Patel, F D'hooge, ... Nature chemical biology 7 (4), 228-235, 2011 | 242 | 2011 |
Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer L Bar-Peled, EK Kemper, RM Suciu, EV Vinogradova, KM Backus, ... Cell 171 (3), 696-709. e23, 2017 | 222 | 2017 |
Discovery of reactive microbiota-derived metabolites that inhibit host proteases CJ Guo, FY Chang, TP Wyche, KM Backus, TM Acker, M Funabashi, ... Cell 168 (3), 517-526. e18, 2017 | 216 | 2017 |
Paracrine induction of HIF by glutamate in breast cancer: EglN1 senses cysteine KJ Briggs, P Koivunen, S Cao, KM Backus, BA Olenchock, H Patel, ... Cell 166 (1), 126-139, 2016 | 203 | 2016 |
Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells MM Blewett, J Xie, BW Zaro, KM Backus, A Altman, JR Teijaro, BF Cravatt Science signaling 9 (445), rs10-rs10, 2016 | 171 | 2016 |
Chemical proteomic profiling of human methyltransferases BD Horning, RM Suciu, DA Ghadiri, OA Ulanovskaya, ML Matthews, ... Journal of the American Chemical Society 138 (40), 13335-13343, 2016 | 91 | 2016 |
The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions KM Backus, MA Dolan, CS Barry, M Joe, P McPhie, HIM Boshoff, ... Journal of Biological Chemistry 289 (36), 25041-25053, 2014 | 66 | 2014 |
SP3‐FAIMS chemoproteomics for high‐coverage profiling of the human cysteinome T Yan, HS Desai, LM Boatner, SL Yen, J Cao, MF Palafox, ... Chembiochem 22 (10), 1841-1851, 2021 | 62 | 2021 |
New approaches to target RNA binding proteins AR Julio, KM Backus Current opinion in chemical biology 62, 13-23, 2021 | 53 | 2021 |
Photoaffinity labelling strategies for mapping the small molecule–protein interactome NR Burton, P Kim, KM Backus Organic & biomolecular chemistry 19 (36), 7792-7809, 2021 | 45 | 2021 |
Applications of reactive cysteine profiling KM Backus Activity-Based Protein Profiling, 375-417, 2019 | 45 | 2019 |
Covalent modulators of the vacuolar ATPase YC Chen, KM Backus, M Merkulova, C Yang, D Brown, BF Cravatt, ... Journal of the American Chemical Society 139 (2), 639-642, 2017 | 43 | 2017 |
ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor CS Barry, KM Backus, CE Barry III, BG Davis Journal of the American Chemical Society 133 (34), 13232-13235, 2011 | 38 | 2011 |
Multiplexed CuAAC Suzuki–Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling J Cao, LM Boatner, HS Desai, NR Burton, E Armenta, NJ Chan, ... Analytical chemistry 93 (4), 2610-2618, 2021 | 36 | 2021 |
CysDB: a human cysteine database based on experimental quantitative chemoproteomics LM Boatner, MF Palafox, DK Schweppe, KM Backus Cell Chemical Biology 30 (6), 683-698. e3, 2023 | 35 | 2023 |
A screen for protein–protein interactions in live mycobacteria reveals a functional link between the virulence-associated lipid transporter LprG and the mycolyltransferase … MH Touchette, ER Van Vlack, L Bai, J Kim, AB Cognetta III, ML Previti, ... ACS infectious diseases 3 (5), 336-348, 2017 | 27 | 2017 |
SP3-Enabled rapid and high coverage chemoproteomic identification of cell-state–dependent redox-sensitive cysteines HS Desai, T Yan, F Yu, AW Sun, M Villanueva, AI Nesvizhskii, KM Backus Molecular & Cellular Proteomics 21 (4), 2022 | 21 | 2022 |
Enhancing cysteine chemoproteomic coverage through systematic assessment of click chemistry product fragmentation T Yan, AB Palmer, DJ Geiszler, DA Polasky, LM Boatner, NR Burton, ... Analytical Chemistry 94 (9), 3800-3810, 2022 | 21 | 2022 |