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Tumor mutational load predicts survival after immunotherapy across multiple cancer types
RM Samstein, CH Lee, AN Shoushtari, MD Hellmann, R Shen, ...
Nature genetics 51 (2), 202-206, 2019
30842019
IDH mutation impairs histone demethylation and results in a block to cell differentiation
C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ...
Nature 483 (7390), 474-478, 2012
21372012
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
S Turcan, D Rohle, A Goenka, LA Walsh, F Fang, E Yilmaz, C Campos, ...
Nature 483 (7390), 479-483, 2012
21102012
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
IK Mellinghoff, MY Wang, I Vivanco, DA Haas-Kogan, S Zhu, EQ Dia, ...
New England Journal of Medicine 353 (19), 2012-2024, 2005
17242005
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
D Rohle, J Popovici-Muller, N Palaskas, S Turcan, C Grommes, ...
Science 340 (6132), 626-630, 2013
12652013
Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
R Beroukhim, G Getz, L Nghiemphu, J Barretina, T Hsueh, D Linhart, ...
Proceedings of the National Academy of Sciences 104 (50), 20007-20012, 2007
12352007
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
MS Neshat, IK Mellinghoff, C Tran, B Stiles, G Thomas, R Petersen, ...
Proceedings of the National Academy of Sciences 98 (18), 10314-10319, 2001
12352001
High-throughput oncogene mutation profiling in human cancer
RK Thomas, AC Baker, RM DeBiasi, W Winckler, T LaFramboise, WM Lin, ...
Nature genetics 39 (3), 347-351, 2007
11602007
A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle
MF Kircher, A De La Zerda, JV Jokerst, CL Zavaleta, PJ Kempen, E Mittra, ...
Nature medicine 18 (5), 829-834, 2012
11512012
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
TF Cloughesy, AY Mochizuki, JR Orpilla, W Hugo, AH Lee, TB Davidson, ...
Nature medicine 25 (3), 477-486, 2019
10942019
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
PY Wen, M Weller, EQ Lee, BM Alexander, JS Barnholtz-Sloan, ...
Neuro-oncology 22 (8), 1073-1113, 2020
7022020
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
GV Thomas, C Tran, IK Mellinghoff, DS Welsbie, E Chan, B Fueger, ...
Nature medicine 12 (1), 122-127, 2006
6882006
Challenges to curing primary brain tumours
K Aldape, KM Brindle, L Chesler, R Chopra, A Gajjar, MR Gilbert, ...
Nature reviews Clinical oncology 16 (8), 509-520, 2019
6702019
Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
TF Cloughesy, K Yoshimoto, P Nghiemphu, K Brown, J Dang, S Zhu, ...
PLoS medicine 5 (1), e8, 2008
6642008
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
L Regales, Y Gong, R Shen, E de Stanchina, I Vivanco, A Goel, ...
The Journal of clinical investigation 119 (10), 3000-3010, 2009
4742009
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid
AM Miller, RH Shah, EI Pentsova, M Pourmaleki, S Briggs, N Distefano, ...
Nature 565 (7741), 654-658, 2019
4512019
An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR–dependent pathway
D Guo, F Reinitz, M Youssef, C Hong, D Nathanson, D Akhavan, D Kuga, ...
Cancer discovery 1 (5), 442-456, 2011
4452011
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
LGT Morris, AM Kaufman, Y Gong, D Ramaswami, LA Walsh, Ş Turcan, ...
Nature genetics 45 (3), 253-261, 2013
4322013
AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
JF Gera, IK Mellinghoff, Y Shi, MB Rettig, C Tran, J Hsu, CL Sawyers, ...
Journal of Biological Chemistry 279 (4), 2737-2746, 2004
4302004
Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies
S Veeriah, BS Taylor, S Meng, F Fang, E Yilmaz, I Vivanco, ...
Nature genetics 42 (1), 77-82, 2010
4142010
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