フォロー
Derek Lowe
Derek Lowe
Research Fellow, Vertex Pharmaceuticals
確認したメール アドレス: novartis.com - ホームページ
タイトル
引用先
引用先
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8342015
The quantum mechanical tunnelling time problem-revisited
S Collins, D Lowe, JR Barker
Journal of Physics C: Solid State Physics 20 (36), 6213, 1987
2161987
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity
J Rudolph, WP Esler, S O'connor, PDG Coish, PL Wickens, M Brands, ...
Journal of medicinal chemistry 50 (21), 5202-5216, 2007
1852007
LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions
S Jepson, B Vought, CH Gross, L Gan, D Austen, JD Frantz, J Zwahlen, ...
Journal of Biological Chemistry 287 (26), 22184-22195, 2012
1362012
Muscarinic antagonists
D Lowe, W Chang, J Kozlowski, JG Berger, R McQuade, A Barnett, ...
US Patent 5,883,096, 1999
1241999
Muscarinic antagonists for treating memory loss
T Asberom, DB Lowe, MJ Green
US Patent 5,952,349, 1999
1071999
Pyrrolo [2, 1-f][1, 2, 4] triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
S O'connor, J Dumas, W Lee, J Dixon, D Cantin, D Gunn, J Burke, ...
US Patent 8,431,695, 2013
1052013
Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose
TH Claus, DB Lowe, Y Liang, AI Salhanick, CK Lubeski, L Yang, ...
Journal of Pharmacology and Experimental Therapeutics 315 (3), 1396-1402, 2005
1042005
A dynamic analysis of resonant tunnelling
S Collins, D Lowe, JR Barker
Journal of Physics C: Solid State Physics 20 (36), 6233, 1987
971987
SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals
GJ Carey, W Billard, H Binch III, M Cohen-Williams, G Crosby, M Grzelak, ...
European journal of pharmacology 431 (2), 189-200, 2001
862001
Muscarinic agonists and antagonists in the treatment of Alzheimer's disease
W Greenlee, J Clader, T Asberom, S McCombie, J Ford, H Guzik, ...
Il Farmaco 56 (4), 247-250, 2001
862001
In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase
DB Lowe, S Magnuson, N Qi, AM Campbell, J Cook, Z Hong, M Wang, ...
Bioorganic & medicinal chemistry letters 14 (12), 3155-3159, 2004
732004
Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-γ binding agents
A Stolle, JP Dumas, W Carley, PDG Coish, SR Magnuson, Y Wang, ...
US Patent 6,787,651, 2004
572004
Muscarinic antagonists
JA Kozlowski, DB Lowe, WK Chang, S Dugar
US Patent 5,935,958, 1999
441999
Design and synthesis of a novel series of orally bioavailable, CNS-penetrant, isoform selective phosphoinositide 3-kinase γ (PI3Kγ) inhibitors with potential for the treatment …
JH Come, PN Collier, JA Henderson, AC Pierce, RJ Davies, A Le Tiran, ...
Journal of Medicinal Chemistry 61 (12), 5245-5256, 2018
392018
4, 5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR
D Gunn, C Akuche, J Baryza, ML Blue, C Brennan, AM Campbell, S Choi, ...
Bioorganic & medicinal chemistry letters 15 (12), 3053-3057, 2005
382005
4, 5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate
J Wood, CM Bagi, C Akuche, A Bacchiocchi, J Baryza, ML Blue, ...
Bioorganic & medicinal chemistry letters 16 (18), 4965-4968, 2006
352006
A model study of field-dependent dynamical screening due to mobile electrons in submicron semiconductor devices
D Lowe, JR Barker
Journal of Physics C: Solid State Physics 18 (12), 2507, 1985
341985
17-beta-hydroxysteroid dehydrogenase-II inhibitors
JE Wood, JL Baryza, CR Brennan, S Choi, JH Cook, BR Dixon, PP Ehrlich, ...
US Patent 6,784,167, 2004
312004
SCH 57790: a novel M2 receptor selective antagonist
JE Lachowicz, D Lowe, RA Duffy, V Ruperto, LA Taylor, H Guzik, J Brown, ...
Life sciences 64 (6-7), 535-539, 1999
311999
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論文 1–20