| Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by … R Shizu, S Benoki, Y Numakura, S Kodama, M Miyata, Y Yamazoe, ... PloS one 8 (4), e61802, 2013 | 60 | 2013 |
| MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor R Shizu, S Shindo, T Yoshida, S Numazawa PloS one 7 (7), e41291, 2012 | 47 | 2012 |
| Phosphorylated nuclear receptor CAR forms a homodimer to repress its constitutive activity for ligand activation R Shizu, M Osabe, L Perera, R Moore, T Sueyoshi, M Negishi Molecular and cellular biology, 2017 | 39 | 2017 |
| PXR functionally interacts with NF-κB and AP-1 to downregulate the inflammation-induced expression of chemokine CXCL2 in mice M Okamura, R Shizu, T Abe, S Kodama, T Hosaka, T Sasaki, K Yoshinari Cells 9 (10), 2296, 2020 | 38 | 2020 |
| Role of YAP activation in nuclear receptor CAR-mediated proliferation of mouse hepatocytes T Abe, Y Amaike, R Shizu, M Takahashi, M Kano, T Hosaka, T Sasaki, ... Toxicological Sciences 165 (2), 408-419, 2018 | 36 | 2018 |
| PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor R Shizu, T Abe, S Benoki, M Takahashi, S Kodama, M Miayata, ... Biochemical Journal 473 (3), 257-266, 2016 | 36 | 2016 |
| Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation R Shizu, J Min, M Sobhany, LC Pedersen, S Mutoh, M Negishi Journal of Biological Chemistry 293 (1), 333-344, 2018 | 23 | 2018 |
| Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of … M Okamura, R Shizu, T Hosaka, T Sasaki, K Yoshinari Drug Metabolism and Pharmacokinetics 34 (4), 272-279, 2019 | 20 | 2019 |
| Nuclear receptor CAR-mediated liver cancer and its species differences R Shizu, K Yoshinari Expert Opinion on Drug Metabolism & Toxicology 16 (4), 343-351, 2020 | 18 | 2020 |
| Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury Y Shimizu, T Sasaki, E Yonekawa, H Yamazaki, R Ogura, M Watanabe, ... The Journal of Toxicological Sciences 46 (4), 167-176, 2021 | 14 | 2021 |
| Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR S Yoshimaru, R Shizu, S Tsuruta, Y Amaike, M Kano, T Hosaka, T Sasaki, ... The Journal of Toxicological Sciences 43 (7), 443-450, 2018 | 13 | 2018 |
| Functional interaction between pregnane X receptor and Yes-associated protein in xenobiotic-dependent liver hypertrophy and drug metabolism T Abe, R Shizu, T Sasaki, Y Shimizu, T Hosaka, S Kodama, A Matsuzawa, ... Journal of Pharmacology and Experimental Therapeutics 371 (3), 590-601, 2019 | 12 | 2019 |
| Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus R Shizu, K Yokobori, L Perera, L Pedersen, M Negishi Scientific Reports 9 (1), 16734, 2019 | 11 | 2019 |
| The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice R Shizu, M Ishimura, S Nobusawa, T Hosaka, T Sasaki, S Kakizaki, ... Archives of Toxicology 95, 1089-1102, 2021 | 9 | 2021 |
| Antiepileptic Drug–Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator–Activated Receptor α and Peroxisome Proliferator–Activated Receptor γ Coactivator … R Shizu, Y Otsuka, K Ezaki, C Ishii, S Arakawa, Y Amaike, T Abe, ... Molecular Pharmacology 98 (5), 634-647, 2020 | 9 | 2020 |
| Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression R Shizu, S Shindo, T Yoshida, S Numazawa Toxicology Letters 219 (2), 143-150, 2013 | 9 | 2013 |
| Application of cytochrome P450 reactivity on the characterization of chemical compounds and its association with repeated-dose toxicity M Watanabe, T Sasaki, J Takeshita, M Kushida, Y Shimizu, H Oki, ... Toxicology and Applied Pharmacology 388, 114854, 2020 | 8 | 2020 |
| Distinct roles of the sister nuclear receptors PXR and CAR in liver cancer development K Yoshinari, R Shizu Drug Metabolism and Disposition 50 (7), 1019-1026, 2022 | 7 | 2022 |
| PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α R Shizu, K Ezaki, T Sato, A Sugawara, T Hosaka, T Sasaki, K Yoshinari Cells 10 (12), 3550, 2021 | 7 | 2021 |
| Chemical characterization of anemia-inducing aniline-related substances and their application to the construction of a decision tree-based anemia prediction model T Asai, J Takeshita, Y Shimizu, Y Tochikubo, R Shizu, T Hosaka, Y Kanno, ... Food and Chemical Toxicology 157, 112548, 2021 | 7 | 2021 |
