| Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19 N Kaneko, HH Kuo, J Boucau, JR Farmer, H Allard-Chamard, ... Cell 183 (1), 143-157. e13, 2020 | 686 | 2020 |
| Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity E Shrock, E Fujimura, T Kula, RT Timms, IH Lee, Y Leng, ML Robinson, ... Science 370 (6520), eabd4250, 2020 | 587 | 2020 |
| Emerging concepts in TCR specificity: rationalizing and (maybe) predicting outcomes NK Singh, TP Riley, SCB Baker, T Borrman, Z Weng, BM Baker The Journal of Immunology 199 (7), 2203-2213, 2017 | 94 | 2017 |
| Computational design of the affinity and specificity of a therapeutic T cell receptor BG Pierce, LM Hellman, M Hossain, NK Singh, CW Vander Kooi, Z Weng, ... PLoS computational biology 10 (2), e1003478, 2014 | 87 | 2014 |
| Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses A Nathan, EJ Rossin, C Kaseke, RJ Park, A Khatri, D Koundakjian, ... Cell 184 (17), 4401-4413. e10, 2021 | 64 | 2021 |
| How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire SJ Blevins, BG Pierce, NK Singh, TP Riley, Y Wang, TT Spear, ... Proceedings of the National Academy of Sciences 113 (9), E1276-E1285, 2016 | 59 | 2016 |
| How an alloreactive T-cell receptor achieves peptide and MHC specificity Y Wang, NK Singh, TT Spear, LM Hellman, KH Piepenbrink, ... Proceedings of the National Academy of Sciences 114 (24), E4792-E4801, 2017 | 52 | 2017 |
| Improving T cell receptor on-target specificity via structure-guided design LM Hellman, KC Foley, NK Singh, JA Alonso, TP Riley, JR Devlin, ... Molecular Therapy 27 (2), 300-313, 2019 | 50 | 2019 |
| Deep mutational scans as a guide to engineering high affinity T cell receptor interactions with peptide-bound major histocompatibility complex DT Harris, N Wang, TP Riley, SD Anderson, NK Singh, E Procko, ... Journal of Biological Chemistry 291 (47), 24566-24578, 2016 | 50 | 2016 |
| Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells T Moore, CR Wagner, GM Scurti, KA Hutchens, C Godellas, AL Clark, ... Cancer Immunology, Immunotherapy 67, 311-325, 2018 | 49 | 2018 |
| Changing the peptide specificity of a human T-cell receptor by directed evolution SN Smith, Y Wang, JL Baylon, NK Singh, BM Baker, E Tajkhorshid, ... Nature communications 5 (1), 5223, 2014 | 44 | 2014 |
| An engineered switch in T cell receptor specificity leads to an unusual but functional binding geometry DT Harris, NK Singh, Q Cai, SN Smith, CW Vander Kooi, E Procko, ... Structure 24 (7), 1142-1154, 2016 | 29 | 2016 |
| A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces TP Riley, CM Ayres, LM Hellman, NK Singh, M Cosiano, JM Cimons, ... Protein Engineering, Design and Selection 29 (12), 595-606, 2016 | 24 | 2016 |
| Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice D Starenki, NK Singh, DR Jensen, FC Peterson, JI Park Cancer letters 339 (1), 144-151, 2013 | 20 | 2013 |
| HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV C Kaseke, RJ Park, NK Singh, D Koundakjian, A Bashirova, WFG Beltran, ... Cell Reports 36 (2), 2021 | 19 | 2021 |
| Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner AR Smith, JA Alonso, CM Ayres, NK Singh, LM Hellman, BM Baker Proceedings of the National Academy of Sciences 118 (4), e2018125118, 2021 | 18 | 2021 |
| Geometrical characterization of T cell receptor binding modes reveals class‐specific binding to maximize access to antigen NK Singh, ET Abualrous, CM Ayres, F Noé, R Gowthaman, BG Pierce, ... Proteins: Structure, Function, and Bioinformatics 88 (3), 503-513, 2020 | 16 | 2020 |
| Computational modeling of T cell receptor complexes TP Riley, NK Singh, BG Pierce, Z Weng, BM Baker Computational Design of Ligand Binding Proteins, 319-340, 2016 | 11 | 2016 |
| Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma BE Grace, CM Backlund, DM Morgan, BH Kang, NK Singh, BD Huisman, ... Frontiers in Immunology 13, 886683, 2022 | 8 | 2022 |
| An engineered T cell receptor variant realizes the limits of functional binding modes NK Singh, JA Alonso, DT Harris, SD Anderson, J Ma, LM Hellman, ... Biochemistry 59 (43), 4163-4175, 2020 | 8 | 2020 |
