Justin Pritchard
Justin Pritchard
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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
PM Bruno, Y Liu, GY Park, J Murai, CE Koch, TJ Eisen, JR Pritchard, ...
Nature medicine 23 (4), 461-471, 2017
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform
JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ...
Nature microbiology 2 (4), 1-9, 2017
Defining principles of combination drug mechanisms of action
JR Pritchard, PM Bruno, LA Gilbert, KL Capron, DA Lauffenburger, ...
Proceedings of the National Academy of Sciences 110 (2), E170-E179, 2013
ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing
JR Pritchard, MC Chao, S Abel, BM Davis, C Baranowski, YJ Zhang, ...
PLoS genetics 10 (11), e1004782, 2014
High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model–based analyses of transposon-insertion sequencing data
MC Chao, JR Pritchard, YJ Zhang, EJ Rubin, J Livny, BM Davis, ...
Nucleic acids research 41 (19), 9033-9048, 2013
Exploiting temporal collateral sensitivity in tumor clonal evolution
B Zhao, JC Sedlak, R Srinivas, P Creixell, JR Pritchard, B Tidor, ...
Cell 165 (1), 234-246, 2016
Addressing Genetic Tumor Heterogeneity through Computationally Predictive Combination TherapyUsing Combination Therapy to Target Tumor Heterogeneity
B Zhao, JR Pritchard, DA Lauffenburger, MT Hemann
Cancer discovery 4 (2), 166-174, 2014
A mammalian functional-genetic approach to characterizing cancer therapeutics
H Jiang, JR Pritchard, RT Williams, DA Lauffenburger, MT Hemann
Nature chemical biology 7 (2), 92-100, 2011
Understanding resistance to combination chemotherapy
JR Pritchard, DA Lauffenburger, MT Hemann
Drug Resistance Updates 15 (5-6), 249-257, 2012
An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor‐α
BD Cosgrove, C Cheng, JR Pritchard, DB Stolz, DA Lauffenburger, ...
Hepatology 48 (1), 276-288, 2008
Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus
L Laencina, V Dubois, V Le Moigne, A Viljoen, L Majlessi, J Pritchard, ...
Proceedings of the National Academy of Sciences 115 (5), E1002-E1011, 2018
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
PM Bruno, M Lu, KA Dennis, H Inam, CJ Moore, J Sheehe, SJ Elledge, ...
Proceedings of the National Academy of Sciences 117 (8), 4053-4060, 2020
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth
CE Meacham, LN Lawton, YM Soto-Feliciano, JR Pritchard, BA Joughin, ...
Genes & development 29 (5), 483-488, 2015
Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors
T Baker, S Nerle, J Pritchard, B Zhao, VM Rivera, A Garner, F Gonzalvez
Oncotarget 6 (32), 32646, 2015
Predicting cancer drug mechanisms of action using molecular network signatures
JR Pritchard, PM Bruno, MT Hemann, DA Lauffenburger
Molecular bioSystems 9 (7), 1604-1619, 2013
RET fusions observed in lung and colorectal cancers are sensitive to ponatinib
JM Gozgit, TH Chen, Y Song, S Wardwell, F Wang, J Cai, H Li, H Edgren, ...
Oncotarget 9 (51), 29654, 2018
Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness
J Wang, JR Pritchard, L Kreitmann, A Montpetit, MA Behr
BMC genomics 15 (1), 1-10, 2014
Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell deathKinase Inhibitors Recreate 17AAG Effects
JR Pritchard, BD Cosgrove, MT Hemann, LG Griffith, JR Wands, ...
Molecular cancer therapeutics 8 (8), 2183-2192, 2009
Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive LeukemiasSubclonal Heterogeneity in …
MW Schmitt, JR Pritchard, SM Leighow, BI Aminov, L Beppu, DS Kim, ...
Clinical Cancer Research 24 (21), 5321-5334, 2018
Comparative TKI profiling analyses to explore potential mechanisms of ponatinib-associated arterial thrombotic events
VM Rivera, JR Pritchard, F Gonzalvez, T Baker, JM Gozgit, G Hodgson
Blood 124 (21), 1783, 2014
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