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Justin Pritchard
Justin Pritchard
Verified email at psu.edu
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Year
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
PM Bruno, Y Liu, GY Park, J Murai, CE Koch, TJ Eisen, JR Pritchard, ...
Nature medicine 23 (4), 461-471, 2017
3192017
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform
JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ...
Nature microbiology 2 (4), 1-9, 2017
2722017
Defining principles of combination drug mechanisms of action
JR Pritchard, PM Bruno, LA Gilbert, KL Capron, DA Lauffenburger, ...
Proceedings of the National Academy of Sciences 110 (2), E170-E179, 2013
1632013
ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing
JR Pritchard, MC Chao, S Abel, BM Davis, C Baranowski, YJ Zhang, ...
PLoS genetics 10 (11), e1004782, 2014
1372014
High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model–based analyses of transposon-insertion sequencing data
MC Chao, JR Pritchard, YJ Zhang, EJ Rubin, J Livny, BM Davis, ...
Nucleic acids research 41 (19), 9033-9048, 2013
1222013
Exploiting temporal collateral sensitivity in tumor clonal evolution
B Zhao, JC Sedlak, R Srinivas, P Creixell, JR Pritchard, B Tidor, ...
Cell 165 (1), 234-246, 2016
1052016
Addressing Genetic Tumor Heterogeneity through Computationally Predictive Combination TherapyUsing Combination Therapy to Target Tumor Heterogeneity
B Zhao, JR Pritchard, DA Lauffenburger, MT Hemann
Cancer discovery 4 (2), 166-174, 2014
1032014
A mammalian functional-genetic approach to characterizing cancer therapeutics
H Jiang, JR Pritchard, RT Williams, DA Lauffenburger, MT Hemann
Nature chemical biology 7 (2), 92-100, 2011
912011
Understanding resistance to combination chemotherapy
JR Pritchard, DA Lauffenburger, MT Hemann
Drug Resistance Updates 15 (5-6), 249-257, 2012
812012
An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor‐α
BD Cosgrove, C Cheng, JR Pritchard, DB Stolz, DA Lauffenburger, ...
Hepatology 48 (1), 276-288, 2008
812008
Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus
L Laencina, V Dubois, V Le Moigne, A Viljoen, L Majlessi, J Pritchard, ...
Proceedings of the National Academy of Sciences 115 (5), E1002-E1011, 2018
692018
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
PM Bruno, M Lu, KA Dennis, H Inam, CJ Moore, J Sheehe, SJ Elledge, ...
Proceedings of the National Academy of Sciences 117 (8), 4053-4060, 2020
632020
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth
CE Meacham, LN Lawton, YM Soto-Feliciano, JR Pritchard, BA Joughin, ...
Genes & development 29 (5), 483-488, 2015
612015
Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors
T Baker, S Nerle, J Pritchard, B Zhao, VM Rivera, A Garner, F Gonzalvez
Oncotarget 6 (32), 32646, 2015
592015
Predicting cancer drug mechanisms of action using molecular network signatures
JR Pritchard, PM Bruno, MT Hemann, DA Lauffenburger
Molecular bioSystems 9 (7), 1604-1619, 2013
322013
RET fusions observed in lung and colorectal cancers are sensitive to ponatinib
JM Gozgit, TH Chen, Y Song, S Wardwell, F Wang, J Cai, H Li, H Edgren, ...
Oncotarget 9 (51), 29654, 2018
242018
Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness
J Wang, JR Pritchard, L Kreitmann, A Montpetit, MA Behr
BMC genomics 15 (1), 1-10, 2014
222014
Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell deathKinase Inhibitors Recreate 17AAG Effects
JR Pritchard, BD Cosgrove, MT Hemann, LG Griffith, JR Wands, ...
Molecular cancer therapeutics 8 (8), 2183-2192, 2009
222009
Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive LeukemiasSubclonal Heterogeneity in …
MW Schmitt, JR Pritchard, SM Leighow, BI Aminov, L Beppu, DS Kim, ...
Clinical Cancer Research 24 (21), 5321-5334, 2018
212018
Comparative TKI profiling analyses to explore potential mechanisms of ponatinib-associated arterial thrombotic events
VM Rivera, JR Pritchard, F Gonzalvez, T Baker, JM Gozgit, G Hodgson
Blood 124 (21), 1783, 2014
202014
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